RNA Biology Laboratory

Selected publications

Leufken J, Niehues A, Sarin LP, Hippler M, Leidel SA**, Fufezan C**. pyQms enables universal and accurate quantification of mass spectrometry data. Mol Cell Proteomics 2017 (in press); doi: 10.1074/mcp.M117.068007.
Pubmed

Mittal N, Guimaraes JC, Gross T, Schmidt A, Vina-Vilaseca A, Nedialkova DD, Aeschimann F, Leidel SA, Spang A, Zavolan M. The Gcn4 Transcription Factor Reduces Protein Synthesis Capacity and Extends Yeast Lifespan. Nature Communications 2017; 8(1): 457.
Pubmed

Braun DA, Rao J, Mollet G, Schapiro D, Daugeron MC, Tan W, Gribouval O, Boyer O, Revy P, Jobst-Schwan T, Schmidt JM, Lawson JA, Schanze D, Ashraf S, Ullmann JFP, Hoogstraten CA, Boddaert N, Collinet B, Martin G, Liger D, Lovric S, Furlano M, Guerrera IC, Sanchez-Ferras O, Hu JF, Boschat AC, Sanquer S, Menten B, Vergult S, De Rocker N, Airik M, Hermle T, Shril S, Widmeier E, Gee HY, Choi WI, Sadowski CE, Pabst WL, Warejko J, Daga A, Basta-Leberre T, Matejas V, Scharmann K, Kienast SD, Behnam B, Beeson B, Begtrup A, Bruce M, Ch'ng GS, Lin SP, Chang JH, Chen CH, Cho MT, Gaffney PM, Gipson PE, Hsu CH, Kari JA, Ke YY, Kiraly-Borri C, Lai W, Lemyre E, Littlejohn RO, Masri A, Moghtaderi M, Nakamura K, Ozaltin F, Praet M, Prasad C, Prytula A, Roeder E, Rump P, Schnur RE, Shiihara T, Sinha M, Soliman NA, Soulami K, Sweetser DA, Tsai WH, Tsai JD, Topaloglu R, Vester U, Viskochil DH, Vatanavicharn N, Waxler JL, Wierenga KJ, Wolf MTF, Wong SN, Leidel SA, Truglio G, Dedon PC, Poduri A, Mane S, Lifton RP, Bouchard M, Kannu P, Chitayat D, Magen D, Calleweart B, van Tilbeurgh H, Zenker M, Antignac C & Hildebrandt F. Mutations in the KEOPS complex genes cause nephrotic syndrome with primary microcephaly. Nature Genetics 2017; 49(10): 1529-1538.
Pubmed

Schaffrath R and Leidel SA. Wobble uridine modifications - a reason to live, a reason to die?! RNA Biology 2017 (in press); doi: 10.1080/15476286.2017.1295204.
Pubmed

Jungfleisch J, Nedialkova DD, Dotu I, Sloan KE, Martinez-Bosch N, Bruening L, Raineri E, Navarro P, Bohnsack MT, Leidel SA, Diez J. A novel translational control mechanism involving RNA structures within coding sequences. Genome Research 2017; 27(1): 95-106.
Pubmed

Malecki J, Aileni V, Ho A, Nilges B, Moen A, Sørensen V, Schwarz J, Jakobsson M, Leidel SA, Falnes P. The novel lysine specific methyltransferase METTL21B affects protein translation through inducible and dynamic methylation of Lys-165 in human eukaryotic elongation factor 1 alpha (eEF1A). Nucleic Acids Research 2017; 45(8): 4370-4389.
Pubmed

Jakobsson ME, Małecki JM, Moen A, Nilges BS, Leidel SA, Falnes PO. Methylation of human eukaryotic elongation factor alpha (eEF1A) by a member of a novel protein lysine methyltransferase family modulates mRNA translation. Nucleic Acids Research 2017; 45(14): 8239-8254.
Pubmed

Delaunay S, Rapino F, Tharun L, Zhou Z, Heukamp L, Termathe M, Shostak K, Klevernic I, Desmet CJ, Nguyen L, Leidel SA, Willis A, Buettner R, Chariot A, Close P. Elp3 links tRNA modification to IRES-dependent translation of LEF1 to sustain metastasis in breast cancer. J Exp Med 2016; 213(11):2503-2523.
Pubmed

Iñigo S, Nagels Durand A, Ritter A, Le Gall S, Termathe M, Klassen R, Tohge T, De Coninck B, Van Leene J, De Clercq R, Cammue BPA, Fernie AR, Gevaert K, De Jaeger G, Leidel SA, Schaffrath R, Van Lijsebettens M, Pauwels L, Goossens A. Glutaredoxin GRXS17 Associates with the Arabidopsis Cytosolic Iron-Sulfur Cluster Assembly Pathway. Plant Physiol 2016; 172(2):858-873.
Pubmed

Lecanda A, Nilges, BS, Sharma P, Nedialkova DD, Schwarz J, Vaquerizas JM, Leidel SA. Dual randomization of oligonucleotides to reduce the bias in ribosome-profiling libraries. Methods 2016; 107:89-97.
Pubmed

Paksa A, Bandemer J, Hoeckendorf B, Razin N, Tarbashevich K, Minina S, Meyen D, Biundo A, Leidel SA, Peyrieras N, Gov NS, Keller PJ, Raz E. Control of progenitor cell positioning and organ patterning during embryogenesis. Nat commun 2016; 7(11288): 1-14.
Pubmed

Rao J, Pfeiffer MJ, Frank S, Adachi K, Piccini I, Quaranta R, Araúzo-Bravo M, Schwarz J, Schade D, Leidel S, Schöler HR, Seebohm G, Greber B. Stepwise Clearance of Repressive Roadblocks Drives Cardiac Induction in Human ES Cells. Cell Stem Cell 2016; 18(3): 341-353
Pubmed

Laguesse S, Creppe C, Nedialkova DD, Prévot PP, Borgs L, Huysseune S, Franco B, Duysens G, Krusy N, Lee G, Thelen N, Thiry M, Close P, Chariot A, Malgrange B, Leidel SA, Godin JD, Nguyen L. A dynamic Unfolded Protein Response contributes to the control of cortical neurogenesis. Dev Cell 2015; 35(5): 553-67.
Pubmed

Baird NJ and Leidel SA. Structures to the people! eLife 2015; 4 (July): 1-3.
Pubmed

Nedialkova DD and Leidel SA. Optimization of codon translation rates via tRNA modifications maintains proteome integrity. Cell 2015; 161(7): 1606-1618 (Open access).
Pubmed

Alings F*, Sarin LP*, Fufezan C, Drexler HCA, Leidel SA. An evolutionary approach uncovers a diverse response of tRNA 2-thiolation to elevated temperatures in yeast. RNA 2015; 21(2): 202-212 (Open access; Featured on the cover).
Pubmed

Sarin LP and Leidel SA. Modify or die? - RNA modification defects in metazoans. RNA Biol 2014; 11(12): 1555-1567 (Open access).
Pubmed

Fernández-Vázquez J, Vargas-Pérez I, Sansó M, Buhne K, Carmona M, Paulo E, Hermand D, Rodríguez-Gabriel M, Ayté J, Leidel S, Hidalgo E. Modification of tRNA(Lys)UUU by elongator is essential for efficient translation of stress mRNAs. PLoS Genet 2013; 9(7):e1003647 (Open access).
Pubmed

Deplazes-Zemp A and Leidel S. Scientific Knowledge Leads to Moral Responsibilities – Case Study Synthetic Biology. In: Common Knowledge: The challenge of transdisciplinarity. Edited by M Cockell, J Billotte, F Darbellay and F Waldvogel. EPFL press 2010, Lausanne: 61-71.

Leslie Pedrioli DM, Karpanen T, Dabouras V, Jurisic G, van de Hoek G, Shin JW, Marino D, Kälin RE, Leidel S, Cinelli P, Schulte-Merker S, Brändli AW and Detmar M. miR-31 functions as a negative regulator of lymphatic vascular lineage-specific differentiation in vitro and vascular development in vivo. Mol Cell Biol 2010; 30(14): 3620-3634.
Pubmed

Leidel S*, Pedrioli PGA*, Bucher T, Brost R, Costanzo M, Schmidt A, Aebersold R, Boone C, Hofmann K, Peter M. Ubiquitin-related modifier Urm1 acts as a sulfur-carrier in thiolation of eukaryotic tRNA. Nature 2009; 458(7235): 228-232.
Pubmed

Pedrioli PGA*, Leidel S*, Hofmann, K. Urm1 at the crossroad of modifications. EMBO rep 2008; 9(12): 1196-1202.
Pubmed

Strnad P, Leidel S, Vinogradova T, Euteneuer, U, Khodjakov A, Gönczy P. Regulated HsSAS-6 levels ensure formation of a single procentriole per centrioles during the centrosome duplication cycle. Dev Cell 2007; 13(2): 203-213.
Pubmed

Leidel S and Gönczy P. Centrosome Duplication and Nematodes: Recent Insights from an Old Relationship. Dev Cell 2005; 5(9): 317-325.
Pubmed

Leidel S, Delattre M, Cerutti L, Baumer K, Gönczy P. SAS-6 defines a protein family required for centrosome duplication in C. elegans and in human cells. Nature Cell Biol 2005; 7(2): 115-125.
Pubmed

Delattre M, Leidel S, Wani K, Baumer K, Bamat J, Schnabel H, Feichtinger R, Schnabel R, Gönczy P. SAS-5 is required for daughter centriole formation in C. elegans. Nature Cell Biol 2004; 6(7): 656-664.
Pubmed

Leidel S and Gönczy P. SAS-4 Is Essential for Centrosome Duplication in C. elegans and Is Recruited to Daughter Centrioles Once per Cell Cycle. Dev Cell 2003; 4(3): 431-439.
Pubmed

Tomilin A, Remenyi A, Lins K, Bak H, Leidel S, Vriend G, Wilmanns M, Schöler HR. Synergism with the coactivator OBF-1 (OCA-B, BOB-1) is mediated by a specific POU dimer configuration. Cell 2000; 103(6): 853-864.
Pubmed

Gönczy P, Echeverri G, Oegema K, Coulson A, Jones SJ, Copley RR, Duperon J, Oegema J, Brehm M, Cassin E, Hannak E, Kirkham M, Pichler S, Flohrs K, Goessen A, Leidel S, Alleaume AM, Martin C, Ozlu N, Bork P, Hyman AA. Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III. Nature 2000; 408(6810): 331-336.
Pubmed

* Shared first authorship
** Co-corresponding authors

 
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