Dr. Roman Tsaryk

I did my Bachelor degree in biochemistry at the National University of Lviv in Ukraine. During my studies I worked in the lab of Prof. Korobov studying the role of hemoglobin in NO-cycle. Afterwards I continued with my Master degree in biochemistry at the National University of Lviv. For my Master thesis I worked in Prof. Stoika’s lab at the Institute of Cell Biology of the National Academy of Sciences of Ukraine, where I studied anti-tumor properties of macrophages.

For my PhD thesis I joined Prof. Kirkpatrick’s lab at the Institute of Pathology, University Medical Center Mainz, Germany. There I was working on the interaction of different biomaterials, such as metal alloys and hydrogels, with endothelial cells in model in vitro system. I extended my skills in tissue engineering during my postdoctoral training working on regeneration of intervertebral disk using hydrogels and mesenchymal stem cells. Simultaneously, I was exploiting several strategies to block angiogenesis in this system, which showed me how important the understanding of basic principles of vascular development and tissue regeneration is for tissue engineering and applied science in general. This brought me to Dr. Arndt Siekmann’s lab for my further postdoctoral training. Here I combine my in vitro experience with one of the best in vivo models to study angiogenesis – zebrafish. My project is devoted to identifying genomic enhancer elements, regulated in endothelial cells by blood flow.

Publications

Tsaryk, R., Fabian, K., Thacker, J., and Kaina, B. (2006). Xrcc2 deficiency sensitizes cells to apoptosis by MNNG and the alkylating anticancer drugs temozolomide, fotemustine and mafosfamide. Cancer Lett 239, 305-313.

Tsaryk, R., Kalbacova, M., Hempel, U., Scharnweber, D., Unger, R. E., Dieter, P., Kirkpatrick, C. J., and Peters, K. (2007). Response of human endothelial cells to oxidative stress on Ti6Al4V alloy. Biomaterials 28, 806-813.

Tsaryk, R., Peters, K., Unger, R.E., Feldmann, M., Hoffmann, B., Heidenau, F., and Kirkpatrick, C.J. (2013) Improving cytocompatibility of Co28Cr6Mo by TiO2 coating: gene expression study in human endothelial cells. J R Soc Interface 86, 20130428.

Tsaryk, R., Peters, K., Unger, R.E., Feldmann, M., Hoffmann, B., Heidenau, F., and Kirkpatrick, C.J. (2013) Improving cytocompatibility of Co28Cr6Mo by TiO2 coating: gene expression study in human endothelial cells. J R Soc Interface 86, 20130428.

Tsaryk, R., Silva-Correia, J., Oliveira, J.M., Unger, R.E., Landes, C., Brochhausen, C., Ghanaati, S., Reis, R.L., Kirkpatrick, C.J. Biological performance of cell-encapsulated methacrylated gellan gum-based hydrogels for nucleus pulposus regeneration. J Tissue Eng Regen Med. 2014 Nov 5. doi: 10.1002/term.1959.