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Hans Schöler Stem Cell Research Center

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Original publication

Jeong Beom Kim, Hyunah Lee, Marcos J Araúzo-Bravo, Kyujin Hwang, Donggyu Nam, Myung Rae Park, Holm Zaehres, Kook In Park & Seok-Jin Lee
Oct4-induced oligodendrocyte progenitor cells enhance functional recovery in spinal cord injury model
EMBO Journal 34(23), 02. Dezember 2015, doi:10.15252/embj.201592652

„Superweapon“ Oct4 creates stem cells for therapy of spinal cord injuries

First publication with Max Planck partner group in „Hans Schöler Stem Cell Research Center“ in South Korea

December 01, 2015

Owing to a myelin sheath that is spirally wrapped around nerve fibers, neurons can adequately conduct their signals. In the brain, this lipid layer is made by so called oligodendrocytes. The importance of this myelin sheath is becoming apparent in demyelinisating dirsorders such as Multiple Sclerosis. Also in therapy concepts for spinal cord injuries, remyelinisation is central. Professor Dr. Jeong Beom Kim, leader of the Max Planck partner group at the 'Hans Schöler Stem Cell Research Center' in Ulsan, South Korea, has shown in collaboration with PD Dr. Holm Zaehres from the department of Professor Dr. Hans Schöler that the protein Oct4 - with a certain combination of culture media - can very efficiently reprogram skin cells into oligodendrocyte precursor cells (iOPCs). The scientists have tested those cells for the first time in a rodent model for spinal cord injuries - with success: the mobility improved after transplantation (EMBO Journal Issue 23, Dezember 2, 2015). This study shows that iOPCs help to understand demyelinisating disorders. Moreover, this approach could be important for future therapies of spinal cord injuries and demyelinisating disorders.
Oligodendrocyte precursor cells (iOPCs) can be kept in culture for over 31 passages. They display typical bipolar morphology and express two oligodendrocyte markers (red and green).
Oligodendrocyte precursor cells (iOPCs) can be kept in culture for over 31 passages. They display typical bipolar morphology and express two oligodendrocyte markers (red and green). [less]

After transplantation into the spinal cord white matter, iOPCs (green) migrate to the place of contusion,  differentiate into myelin-producing oligodendrocytes (red) and remyelinate the axons (blue) of neurons.
After transplantation into the spinal cord white matter, iOPCs (green) migrate to the place of contusion,  differentiate into myelin-producing oligodendrocytes (red) and remyelinate the axons (blue) of neurons. [less]

The ‚Hans Schöler Stem Cell Research Center’ in Ulsan, South Korea, was inaugurated on August 13, 2010 and is dedicated to exploring the possibilities of the iPS technologie in regard to cell replacement therapies.

The Max Planck partner group at the ‚Hans Schöler Stem Cell Research Center’ was initiated in 2012 by the Max Planck Institute for Molecular Biomedicine and is headed by Professor Dr. Jeong Beom Kim, who did  research on his doctoral thesis from 2005 until 2009 with Hans Schöler. The Max Planck partner group was positively evaluated after three years and will be up and running until the end of 2016. The partner group intensifies the existing cooperation between the two institutions.

 
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