Stem Cell Biology / REBIRTH

Publications

Pfaff N, Lachmann N, Ackermann M, Kohlscheen S, Brendel C, Maetzig T, Niemann H, Antoniou MN, Grez M, Schambach A, Cantz T, Moritz T (2013). A ubiquitous chromatin opening element (UCOE) prevents transgene silencing in pluripotent stem cells and their differentiated progeny. Stem Cells 31(3):488-99

Schmeckebier S, Mauritz C, Katsirntaki K, Sgodda M, Puppe V, Duerr J, Schubert SC, Schmiedl A, Lin Q, Palecek J, Draeger G, Ochs M, Zenke M, Cantz T, Mall MA, Martin U (2013). Keratinocyte Growth Factor and Dexamethasone Plus Elevated cAMP Levels Synergistically Support Pluripotent Stem Cell Differentiation into Alveolar Epithelial Type II Cells. Tissue Eng Part A 19(7-8):938-51

Sgodda M, Cantz T (2013). Small but Significant: Inter- and Intrapatient Variations in iPS Cell-based Disease Modeling. Mol Ther 21(1):5-7

Yuan Q, Loya K, Rani B, Mobus S, Balakrishnan A, Lamle J, Cathomen T, Vogel A, Manns MP, Ott M, Cantz T, Sharma AD (2013). MicroRNA-221 overexpression accelerates hepatocyte proliferation during liver regeneration. Hepatology 57(1):299-310

Grabundzija I, Wang J, Sebe A, Erdei Z, Kajdi R, Devaraj A, Steinemamm D, Szuhai K, Stein U, Cantz T, Schambach A, Baum C, Izsvak Z, Sarkadi B, Ivics Z (2013). Sleeping Beauty Transposon-based System for Cellular Reprogramming and Targeted Gene Insertion in Induced Pluripotent Stem Cells. Nucleic Acid Research 41(3):1829-47

Eberle I, Moslem M, Henschler R, Cantz T (2012). Engineered MSCs from Patient-Specific iPS Cells. Adv Biochem Eng Biotechnol 2012 Aug 23. [Epub ahead of print]

Gross B, Pittermann E, Reinhardt D, Cantz T, Klusmann JH (2012). Prospects and challenges of reprogrammed cells in hematology and oncology. Pediatr Hematol Oncol 29(6):507-28

Kleger A, Mahaddalkar O, Katz SF, Lechel A, Ju JY, Loya K, Kin Q, Hartmann D, Liebau S, Kraus J, Cantz T, Kestler HA, Zaehres H, Schöler HR, Rudolph KL (2012). Liver progenitor cells exhibit BAF-complex dependent increases in reprogramming capacity compared to differentiated liver cells. Gastroenterology 142(4):907-17

Lachmann N, Jagielska J, Heckl D, Brennig S, Pfaff N, Maetzig T, Modlich U, Cantz T, Gentner B, Schambach A, Moritz T (2012). MicroRNA-150-regulated vectors allow lymphocyte-sparing transgene expression in hematopoietic gene therapy. Gene Ther 19(9):915-24

Pfaff N, Moritz T, Thum T, Cantz T (2012). miRNAs involved in the generation, maintencance, and differentiation of pluripotent stem cells. J Mol Med 90(7):747-52

Eggenschwiler R, Loya K, Sgodda M, Andre F, Cantz T (2011). Hepatic differentiation of murine disease-specific induced pluripotent stem cells allows disease modelling in vitro. Stem Cells Int 2011:924782.

Haake C, Bonk S, Parsiegla J, Tomala M, Loya K, Sgodda M, Cantz T, Schambach A, Kasper C, Scheper T (2011). Comparison of the activity and pluripotency maintaining potential of human leukemia inhibitory factor (LIF) produced in E.coli and CHO cells. BMC Proc. 5 Suppl 8:P109.

Osiak A, Radecke F, Guhl E, Radecke S, Dannemann N, Lutge F, Glage S, Rudolph C, Cantz T, Schwarz K, Heilbronn R, Cathomen T (2011). Selection-independent generation of gene knockout mouse embryonic stem cells using zinc-finger nucleases. PLoS ONE 6(12):e28911.

Pfaff N, Fiedler J, Holzmann A, Schambach A, Moritz T, Cantz T, Thum T (2011). miRNA screening reveals a new miRNA family stimulating iPS cell generation via regulation of Meox2. EMBO Rep 12(11):1153-9.

Wu G, Gentile L, Do JT, Cantz T, Sutter J, Psathaki K, Ara XfZ-BMJ, Ortmeier C, Schöler HR (2011). Efficient Derivation of Pluripotent Stem Cells from siRNA-Mediated Cdx2-Deficient Mouse Embryos. Stem Cells Dev 20(3):809-18.

Wu G, Liu N, Rittelmeyer I, Sharma AD, Sgodda M, Zaehres H, Bleidissel M, Greber B, Gentile L, Han DW, Rudolph C, Steinemann D, Schambach A, Ott M, Schöler HR, Cantz T. Generation of Healthy Mice from Gene-Corrected Disease-Specific Induced Pluripotent Stem Cells. PLoS Biol 9(7):e1001099

Wurm M, Groß B, Sgodda M, Ständker L, Müller T, Forssmann WG, Horn PA, Blasczyk R, Cantz T (2011). Improved lentiviral gene transfer into human embryonic stem cells grown in co-culture with murine feeder and stroma cells. Biol Chem 392(10):887-95

Pfaff N, Lachmann N, Kohlscheen S, Sgodda M, Araúzo-Bravo MJ, Greber B, Kues WA, Glage S, Baum C, Niemann H, Schambach A,Cantz T, Moritz T (2011). Efficient hematopoietic redifferentiation of induced pluripotent stem cells derived from primitive murine bone marrow cells. Stem Cells Dev 21(5):689-701

Tiemann U, Sgodda M, Warlich E, Ballmaier M, Schöler HR, Schambach A, Cantz T (2011). Optimal Reprogramming Factor Stoichiometry Increases Colony Numbers and Affects Molecular Characteristics of Murine Induced Pluripotent Stem Cells. Cytometry Part A, 9(6):426-435

Terwel D, Löschmann YN, Schmidt HH, Schöler HR, Cantz T, Heneka MT (2011). Neuroinflammatory and behavioural changes in the Atp7B mutant mouse model of Wilson's disease. J Neurochem, 118(1):105-112

Sharma AD, Narain N, Händel EM, Iken M, Singhal N, Cathomen T, Manns MP, Schöler HR, Ott M, Cantz T (2011). MicroRNA-221 regulates FAS-induced fulminant liver failure. Hepatology, 53(5):1651-1661

Warlich E, Kühle J, Cantz T, Brugman MH, Mätzig T, Galla M, Filipczyk A, Halle S, Klump H, Schöler HR, Baum C, Schroeder T, and Schambach A (2011). Lentiviral Vector Design and Imaging Approaches to Visualize the Early Stages of Cellular Reprogramming. Mol Ther, 19(4):782-789

Zaehres H, Kögler G, Bleidissel M, Arauzo-Bravo M, Santourlidis S, Weinhold S, Greber B, Kim JB, Buchheiser A, Liedtke S, Graffmann N, Zhao X, Meyer H, Reinhardt P, Waclawczyk S, Ortmeier C, Uhrberg M, Schöler HR*, Cantz T*, Wernet P* (2010). Induction of pluripotency in human cord blood unrestricted somatic stem cells. Exp Hematol., 38(9):809-18 (*corresponding authors)

Wu G, Gentile L, Do JT, Cantz T, Sutter J, Psathaki K, Araúzo-Bravo MJ, Ortmeier C, Scholer H (2010). Efficient Derivation of Pluripotent Stem Cells from siRNA-Mediated Cdx2-deficient Mouse Embryos. Stem Cells Dev, Jun 10. [Epub ahead of print]

Schambach A, Cantz T, Baum C, Cathomen T (2010). Reprogramming somatic cells into induced pluripotent stem cells. Expert Opinion On Biological Therapy (Review), 10(7):1089-103.

Voelkel C, Galla M, Maetzig T, Warlich E, Kuehle J, Zychlinski D, Bode J, Cantz T, Schambach A, Baum C (2010). Protein transduction from retroviral Gag precursors. PNAS, 107(17):7805-10.

Tomala M, Lavrentieva A, Moretti P, Rinas U, Kasper C, Stahl F, Schambach A, Warlich E, Martin U, Cantz T, Scheper T (2010). Preparation of bioactive soluble human leukemia inhibitory factor from recombinant Escherichia coli using thioredoxin as fusion partner. Protein Expr Purif., 73(1):51-7

Cantz T, Martin U (2010). Induced Pluripotent Stem (iPS) Cells: Characteristics and Perspectives. Advances in Biochemical Engineering/Biotechnology (Review), 123:107-26

Kriegeskotte C, Cantz T, Haberland J, Zibert A,  Haier J, Köhler G, Schöler HR, Schmidt HHJ, Arlinghaus HF. Laser Secondary Neutral Mass Spectrometry for Copper Detection in Micro-Scale Biopsies. J Mass Spec, 2009, 44(10):1417-22.

Haridass D, Yuan Q, Becker PD, Cantz T, Iken M, Rothe M, Narain N, Bock M, Nörder M, Legrand M, Wedemeyer H, Weijer K, Spits H, Manns MP, Cai J, Deng H, Di Santo JP, Guzman CA, Ott M. Repopulation efficiencies of adult hepatocytes, fetal liver progenitor cells and embryonic stem cell-derived hepatic cells in Alb-uPA mice. Am J Pathol, 2009, 175(4):1483-92

Loya K, Eggenschwiler R, Ko K, Sgodda M, André F, Bleidißel M, Schöler HR, and Cantz T. Hepatic differentiation of pluripotent stem cells, Biol Chem, 2009, 390(10):1047-1055.

Eggenschwiler R, Cantz T. Induced pluripotent stem cells generated without viral integration. Hepatology, 2009;49(3):1048-9 [Comment in "Hepatology Elsewhere"]

Sancho-Bru P, Najimi M, Caruso M, Pawelyn K, Cantz T, Forbes SJ, Roskams T, Ott M, Gehling U, Sokal E, Verfaillie C, Muraca M. Stem and progenitor cells for liver repopulation: can we standardize the process from bench to bedside? Gut, 2009; 58(4):594-603

Cantz T, Bleidißel M, Stehling M, Schöler HR. In vitro differentiation of reprogrammed murine somatic cells into hepatic precursor cells. Biol Chem, 2008; 389:889–896

Cantz T, Key G, Bleidißel M, Brenne A, Schöler HR. Absence of Oct4 expression in somatic tumor cell lines. Stem Cells, 2008; 26:692– 697

Sharma AD, Cantz T, Vogel A, Schambach A, Hairdass D, Iken M, Bleidißel M, Manns MP, Schöler HR, Ott M. Murine Embryonic Stem Cell-Derived Hepatic Progenitor Cells Engraft in Recipient Livers with Limited Capacity of Liver Tissue Formation. Cell Transplantation, 2008; 17:313–323

Cantz T, Manns MP, Ott M. Stem Cells in Liver Regeneration and Therapy. (Review) Cell & Tissue Research, 2007; 331(1): 271-282

Sharma AD, Cantz T, Manns MP, Ott M. The role of stem cells in physiology, pathophysiology, and therapy of the liver. (Review) Stem Cell Rev, 2006; 2(1):51-8.

Kirchner GI, Rifai K, Cantz T, Nashan B, Terkamp C, Becker T, Strassburg C, Barg-Hock H, Wagner S, Luck R, Klempnauer J, Manns MP. Outcome and quality of life in patients with polycystic liver disease after liver or combined liver-kidney transplantation. Liver Transpl. 2006; 12(8):1268-77.

Ormandy LA, Farber A, Cantz T, Petrykowska S, Wedemeyer H, Horning M, Lehner F, Manns MP, Korangy F, Greten TF. Direct ex vivo analysis of dendritic cells in patients with hepatocellular carcinoma. World J Gastroenterol. 2006; 12(20):3275-82.

Rifai K, Kirchner GI, Bahr MJ, Cantz T, Rosenau J, Nashan B, Klempnauer JL, Manns MP, Strassburg CP. A new side effect of immunosuppression: High incidence of hearing impairment after liver transplantation. Liver Transplantation. 2005; 12(3):411-5

Rifai K, Bahr M, Cantz T, Klempnauer J, Manns MP, Strassburg CP. Severe hearing loss after liver transplantation. Transplant Proc. 2005; 37(4):1918-9.

Sharma AD, Cantz T, Richter R, Eckert K, Henschler R, Wilkens L, Jochheim-Richter A, Arseniev L, Ott M. Human cord blood stem cells generate human cytokeratin 18 negative hepatocyte-like cells in injured mouse liver. Am J Pathol. 2005; 167(2):555-64.

Cantz T, Sharma AD, Jochheim-Richter A, Arseniev L, Klein C, Manns MP, Ott M. Reevaluation of bone marrow derived cells as a source for hepatocyte regeneration.Cell Transplantation. 2004; 13:659–666

Cantz T, Jochheim A, Cieslak A, Hillemann T, Scharf J, Manns MP, Ott M. PCR-based quantification of amplified RNA from laser microdissected mouse liver samples.Exp. Mol. Pathol. 2003, 75(1):53-57

Cantz T, Zuckerman DM, Burda MR, Dandri M, Göricke B, Thalhammer S, Heckl WM, Manns MP, Petersen J, Ott M. Quantitative gene expression analysis reveals transition of fetal liver progenitor cells to mature hepatocytes after transplantation in uPA/RAG-2 mice. Am J Pathol. 2003; 162(1):37-45.

Jochheim A, Cieslak A, Hillemann T, Cantz T, Scharf J, Manns MP, Ott M. Multi-stage analysis of differential gene expression in BALB/C mouse liver development by high-density microarrays. Differentiation. 2003; 71(1):62-72.

Cantz T, Ott M, Kubicka S, Manns MP. Gen- und Immuntherapie von Lebererkrankungen. (Review) Internist. 2001; 42(10):1357-65.

Cantz T, Nies AT, Brom M, Hofmann AF, Keppler D.MRP2, a human conjugate export pump, is present and transports Fluo 3 into apical Vacuoles of HepG2 cells. Am. J. Physiol. 2000; (278):G522-G531

Nies AT, Cantz T, Brom M, Leier I, Keppler D. Expression of the apical conjugate export pump, Mrp2, in the polarized hepatoma cell line, WIF-B. Hepatology. 1998; (28):1332-40.

 
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