Human Stem Cell Pluripotency Laboratory


Beitrag zum Jahrbuch der Max-Planck-Gesellschaft

"Herzmuskelgewebe aus pluripotenten Stammzellen - wie das geht und wozu es zu gebrauchen ist" | Boris Greber

Jahrbuchbeiträge sind allgemein verständlich formuliert und haben den Zweck, unseren Zuwendungsgebern, interessierten Laien und fachfremden Wissenschaftlern einen Einblick in unsere Forschungsarbeit zu geben.


Link to PubMed


Publications with major contributions (2012 - )

I. Piccini, E. Fehrmann, S. Frank, F.U. Müller, B. Greber*, G. Seebohm*, Adrenergic Stress Protection of Human iPS Cell-Derived Cardiomyocytes by Fast Kv7.1 Recycling, Frontiers in Physiology, 8 (2017) 705.

M. Marczenke, I. Piccini, I. Mengarelli, J. Fell, A. Röpke, G. Seebohm, A.O. Verkerk*, B. Greber*, Cardiac subtype-specific modelling of Kv1.5 ion channel deficiency using human pluripotent stem cells, Frontiers in Physiology, 8 (2017) 469.

M. Marczenke, J. Fell, I. Piccini, A. Ropke, G. Seebohm, B. Greber, Generation and cardiac subtype-specific differentiation of PITX2-deficient human iPS cell lines for exploring familial atrial fibrillation, Stem Cell Research, 21 (2017) 26-28.

J. Rao, B. Greber, Concise Review: Signaling control of early fate decisions around the human pluripotent stem cell state, Stem Cells, 35 (2017) 277-283.

I. Piccini, M. Arauzo-Bravo, G. Seebohm, B. Greber, Functional high-resolution time-course expression analysis of human embryonic stem cells undergoing cardiac induction, Genom Data, 10 (2016) 71-74.

D. Malan, M. Zhang, B. Stallmeyer, J. Müller, B.K. Fleischmann, E. Schulze-Bahr, P. Sasse*, B. Greber*, Human iPS cell model of type 3 long QT syndrome recapitulates drug-based phenotype correction, Basic Res Cardiol, 111 (2016) 14.

J. Rao, M.J. Pfeiffer, S. Frank, K. Adachi, I. Piccini, R. Quaranta, M. Arauzo-Bravo, J. Schwarz, D. Schade, S. Leidel, H.R. Schöler, G. Seebohm, B. Greber, Stepwise clearance of repressive roadblocks drives cardiac induction in human ESCs, Cell Stem Cell, 18 (2016) 341-353.
Press release

D. Schade, A. Hansen, B. Greber, Human pluripotent stem cell-derived cardiomyocytes in drug discovery and development, Drug Target Review, (2015) 34-38.

I. Piccini, J. Rao, G. Seebohm, B. Greber, Human pluripotent stem cell-derived cardiomyocytes: Genome-wide expression profiling of long-term in vitro maturation in comparison to human heart tissue, Genomics Data, 4 (2015) 69-72.

M. Bellin, B. Greber, Human iPS cell models of Jervell and Lange-Nielsen syndrome, Rare Diseases, 3 (2015) 1-4.

B. Greber, A.O. Verkerk, G. Seebohm, C.L. Mummery, M. Bellin, Reply to Christ et al.: LQT1 and JLNS phenotypes in hiPSC-derived cardiomyocytes are due to KCNQ1 mutations, PNAS, 112 (2015) E1969.

M. Zhang, J.S. Schulte, A. Heinick, I. Piccini, J. Rao, R. Quaranta, D. Zeuschner, D. Malan, K.P. Kim, A. Ropke, P. Sasse, M. Arauzo-Bravo, G. Seebohm, H. Schöler, L. Fabritz, P. Kirchhof, F.U. Müller, B. Greber, Universal cardiac induction of human pluripotent stem cells in two and three-dimensional formats: implications for in vitro maturation, Stem Cells, 33 (2015) 1456-1469.

M. Zhang, C. D'Aniello, A.O. Verkerk, E. Wrobel, S. Frank, D. Ward-van Oostwaard, I. Piccini, C. Freund, J. Rao, G. Seebohm, D.E. Atsma, E. Schulze-Bahr, C.L. Mummery, B. Greber*, M. Bellin*, Recessive cardiac phenotypes in induced pluripotent stem cell models of Jervell and Lange-Nielsen syndrome: disease mechanisms and pharmacological rescue, PNAS, 111 (2014) E5383-5392.
Press release

J. Rao, B. Greber, Conversion of epiblast stem cells to embryonic stem cells using growth factors and small molecule inhibitors, Methods in molecular biology, 1150 (2014) 215-226.

S. Frank, B.V. Skryabin, B. Greber, A modified TALEN-based system for robust generation of knock-out human pluripotent stem cell lines and disease models, BMC Genomics, 14 (2013) 773.

M. Zhang, H.R. Schöler, B. Greber, Rapid and efficient generation of neurons from human pluripotent stem cells in a multititre plate format, J Vis Exp, (2013).

S. Frank, M. Zhang, H.R. Schöler, B. Greber, Small molecule-assisted, line-independent maintenance of human pluripotent stem cells in defined conditions, PLoS One, 7 (2012) e41958.

* equal contributions

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