Laboratory for Cardiovascular Patterning

Selected publications

Sugden W.W., Leonardo-Mendonca R.C., Acuna-Castroviejo D., Siekmann A.F. (2017): Genetic dissection of endothelial transcriptional activity of zebrafish aryl hydrocarbon receptors (AHRs). PLoS ONE, 12(8):e0183433.

Hasan SS, Tsaryk R, Lange M, Wisniewski L, Moore JC, Lawson ND, et al. Endothelial Notch signalling limits angiogenesis via control of artery formation. Nature cell biology, 2017.

Sugden WW, Meissner R, Aegerter-Wilmsen T, Tsaryk R, Leonard EV, Bussmann J, et al. Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues. Nature cell biology, 2017;19(6):653-65.

Papangeli I., Kim J., Maier I., Lee A., Kang Y., Ju H., Kojima Y., Siekmann A.F. and Chun H.J. (2016). MicroRNA 139-5p Coordinates APLNR-CXCR4 Crosstalk during Vascular Maturation. Nature communications, 12. April 2016, doi: 10.1038/ncomms11268.

Xu, C., Volkery, S., and Siekmann, A.F. (2015). Intubation-based anesthesia for long-term time-lapse imaging of adult zebrafish. Nat Protoc 10, 2064-2073.

Hasan, S.S., and Siekmann, A.F. (2015). The same but different: signaling pathways in control of endothelial cell migration. Curr Opin Cell Biol 36, 86-92.

Harrison, M.R., Bussmann, J., Huang, Y., Zhao, L., Osorio, A., Burns, C.G., Burns, C.E., Sucov, H.M., Siekmann, A.F., and Lien, C.L. (2015). Chemokine-guided angiogenesis directs coronary vasculature formation in zebrafish. Dev Cell 33, 442-454.

Xu C., Hasan S.S., Schmidt, I., Rocha, S.F., Pitulescu, M.E., Bussmann, J., Meyen, D., Raz, E., Adams, R.H., Siekmann, A.F. (2014): Arteries are formed by vein-derived endothelial tip cells. Nature Communications, 15. December 2014, doi:10.1038/ncomms6758.

Quillien A., Moore J.C., Shin M., Siekmann A.F., Smith T., Pan L., Moens C.B., Parsons M.J., Lawson N.D. (2014): Distinct Notch signaling outputs pattern the developing arterial system. Development, 141(7):1544-52.

Kochhan E., Lenard, A., Ellertsdottir, E., Herwig, L., Affolter, M., Belting, H.G., Siekmann, A.F. (2013):Blood flow changes coincide with cellular rearrangements during blood vessel pruning in zebrafish embryos. PLoS ONE, 8(10):e75060.

Kochhan E., Siekmann, A.F. (2013): Zebrafish as a model to study chemokine function. Methods Molecular Biology, 1013:145-59.

Siekmann, A.F., Affolter, M., Belting, H.G. (2013): The tip cell concept 10 years after: new players tuning in for a common theme. Experimental Cell Research, 15; 319(9):1255-63.

Cha Y.R., Fujita M., Butler M., Isogai S., Kochhan E., Siekmann A.F., Weinstein B.M. (2012): Chemokine signaling directs trunk lymphatic network formation along the preexisting blood vasculature. Developmental Cell, 17;22(4):824-36.

Zhu C., Smith T., McNulty J., Rayla A.L., Lakshmanan A., Siekmann A.F., Buffardi M., Meng X., Shin J., Padmanabhan A., Cifuentes D., Giraldez A.J., Look A.T., Epstein J.A., Lawson N.D., Wolfe S.A. (2011): Evaluation and application of modularly assembled zinc-finger nucleases in zebrafish. Development, 138(20):4555-64.

Bussmann, J., Wolfe, S.A., Siekmann, A.F. (2011): Arterial-venous network formation during brain vascularization involves hemodynamic regulation of chemokine signalling. Development, 138: 1717-1726.

Kiefer, F., Siekmann, A.F. (2011): The role of chemokines and their receptors in angiogenesis. Cellular Molecular Life Sciences, 68(17):2811-30.

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