Molecular Neurogenetics Laboratory

Publications

Scekic-Zahirovic J, El Oussini H, Mersmann S, Drenner K, Wagner M, Sun Y, Allmeroth K, Dieterlé S, Sinniger J, Dirrig-Grosch S, René F, Dormann D, Haass C, Ludolph A, Lagier-Tourenne C, Storkebaum E*, Dupuis L*. Motor neuron intrinsic and extrinsic mechanisms contribute to the pathogenesis of FUS-associated amyotrophic lateral sclerosis. Acta Neuropathologica 2017, DOI 10.1007/s00401-017-1687-9 *corresponding authors.

Bussmann J, Storkebaum E. Molecular pathogenesis of peripheral neuropathies: Insights from Drosophila models. Current Opinion in Genetics and Development 2017; 44: 61-73.

Storkebaum E. Peripheral neuropathy via mutant tRNA synthetases: inhibition of protein translation provides a possible explanation. BioEssays 2016; 38(9): 818-29.

Lange C, Storkebaum E, Ruiz de Almodovar C, Dewerchin M, Carmeliet P. Vascular endothelial growth factor: a neurovascular target in neurological diseases. Nature Reviews Neurology 2016; 12(8): 439-54.

Scekic-Zahirovic J, Sendscheid O, El Oussini H, Jambeau M, Ying S, Mersmann S, Wagner M, Dieterlé S, Sinniger J, Dirrig-Grosch S, Drenner K, Birling M, Qui J, Zhou Y, Li H, Fu X, Rouaux C, Shelkovnikova T, Witting A, Ludolph A, Kiefer F, Storkebaum E*, Lagier-Tourenne C*, Dupuis L*. Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss. EMBO Journal 2016; 35(10): 1077-97. *corresponding authors.

Niehues S, Bussmann J, Steffes G, Erdmann I, Köhrer C, Sun L, Wagner M, Schäfer K, Wang G, Koerdt SN, Stum M, RajBhandary UL, Thomas U,  Aberle H, Burgess RW, Yang X-L, Dieterich D, Storkebaum E. Impaired protein translation in Drosophila models for Charcot-Marie-Tooth neuropathy caused by mutant tRNA synthetases. Nature Communications 2015; 6:7520 doi: 10.1038/ncomms8520.

Erdmann I, Marter K, Kobler O, Niehues S, Abele J, Müller A, Bussmann J, Storkebaum E, Ziv T, Thomas U, Dieterich D. Cell-selective labeling of proteomes in Drosophila melanogaster. Nature Communications 2015; 6:7521 doi: 10.1038/ncomms8521.

Frickenhaus M, Wagner M, Mallik M, Catinozzi M, Storkebaum E. Highly-efficient cell-type-specific gene inactivation reveals a key function for the Drosophila FUS homolog cabeza in neurons. Scientific Reports 2015; 5: 9107; DOI:10.1038/srep09107.

Steffes G, Storkebaum E. Drosophila as a model for CMT peripheral neuropathy: mutations in tRNA synthetases as an example. In "Drosophila melanogaster models of motor neuron disease" Editor: R.J. Cauchi; publisher: Nova Biomedical 2013; 121-146.

Storkebaum E, Quaegebeur A, Vikkula M, Carmeliet P. Cerebrovascular disorders: molecular insights and therapeutic opportunities. Nature Neuroscience 2011; 14(11): 1390-1397.

Storkebaum E, Carmeliet P. Paracrine control of vascular innervation in health and disease. Acta Physiol 2011; 203(1): 61-86

Storkebaum E, Ruiz de Almodovar, C, Meens M, Zacchigna S, Mazzone M, Vanhoutte G, Vinckier S, Miskiewicz K, Poesen K, Lambrechts D, Janssen G, Fazzi G, Verstreken P, Haigh J, Schiffers P, Rohrer H, Van der Linden A, De Mey J, Carmeliet P. Impaired autonomic regulation of resistance arteries in VEGF∂/∂ mice or upon VEGF-trap delivery. Circulation 2010; 122: 273-281.

Storkebaum E, Leitao-Gonçalves R, Godenschwege T, Nangle L, Mejia M, Bosmans I, Ooms T, Jacobs A, Van Dijck P, Yang X-L, Schimmel P, Norga K, Timmerman V, Callaerts P and Jordanova A. Dominant mutations in the tyrosyl-tRNA synthetase gene recapitulate in Drosophila features of human Charcot-Marie-Tooth neuropathy. Proc Natl Acad Sci USA 2009;106(28): 11782-11787.

Storkebaum E, Lambrechts D, Dewerchin M, Oh H, Vermeulen K, Van Damme P, Man WY, Demol M, Wyns S, Manka D, Van Den Bosch L., Mertens N, Robberecht W, Conway EM, Collen D, Moons L and Carmeliet P. Treatment of an aggressive form of motoneuron degeneration by intracerebroventricular delivery of recombinant VEGF in ALS animal models. Nature Neuroscience 2005 Jan;8(1):85-92.

Van Den Bosch L, Storkebaum E, Vleminckx V, Moons L, Vanopdenbosch L, Scheveneels W, Carmeliet P, Robberecht W. Effects of vascular endothelial growth factor (VEGF) on motor neuron degeneration. Neurobiol Dis 2004 Oct;17(1):21-8.

Storkebaum E, Lambrechts D, Carmeliet P. VEGF: once regarded as a specific angiogenic factor, now implicated in neuroprotection. BioEssays 2004 Sep;26(9):943-54.

Lambrechts D, Storkebaum E, Carmeliet P. VEGF: necessary to prevent motoneuron degeneration, sufficient to treat ALS? Trends Mol Med 2004 Jun;10(6):275-82.

Azzouz M, Ralph GS, Storkebaum E, Walmsley LE, Mitrophanous KA, Kingsman SM, Carmeliet P, Mazarakis ND. VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model. Nature 2004 May 27;429(6990):413-7.

Storkebaum E, Carmeliet P. VEGF: a critical player in neurodegeneration. J Clin Invest 2004 Jan;113(1):14-8.

Lambrechts D, Storkebaum E, Morimoto M, Del-Favero J, Desmet F, Marklund SL, Wyns S, Thijs V, Andersson J, van Marion I, Al-Chalabi A, Bornes S, Musson R, Hansen V, Beckman L, Adolfsson R, Pall HS, Prats H, Vermeire S, Rutgeerts P, Katayama S, Awata T, Leigh N, Lang-Lazdunski L, Dewerchin M, Shaw C, Moons L, Vlietinck R, Morrison KE, Robberecht W, Van Broeckhoven C, Collen D, Andersen PM, Carmeliet P. VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death. Nature Genetics 2003 Aug;34(4):383-94.

Luttun A, Lupu F, Storkebaum E, Hoylaerts MF, Moons L, Crawley J, Bono F, Poole AR, Tipping P, Herbert JM, Collen D, Carmeliet P. Lack of plasminogen activator inhibitor-1 promotes growth and abnormal matrix remodeling of advanced atherosclerotic plaques in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 2002 Mar 1;22(3):499-505.

Carmeliet P, Storkebaum E. Vascular and neuronal effects of VEGF in the nervous system: implications for neurological disorders. Semin Cell Dev Biol 2002 Feb;13(1):39-53.

Oosthuyse B, Moons L, Storkebaum E, Beck H, Nuyens D, Brusselmans K, Dorpe JV, Hellings P, Gorselink M, Heymans S, Theilmeier G, Dewerchin M, Laudenbach V, Vermylen P, Raat H, Acker T, Vleminckx V, Van Den Bosch L, Cashman N, Fujisawa H, Drost MR, Sciot R, Bruyninckx F, Hicklin DJ, Ince C, Gressens P, Lupu F, Plate KH, Robberecht W, Herbert JM, Collen D, Carmeliet P. Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration. Nature Genetics 2001 Jun;28(2):131-8.

 

 
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