Selected publications
A. Zarbock, T Kempf , K.C. Wollert and Vestweber D. (2001) Leukocyte integrin activation and deactivation: novel mechanisms of balancing inflammation. J. Mol. Med. (Berl). [Epub ahead of print]
A. Broermann, M. Winderlich, H. Block, M. Frye, J. Rossaint, A. Zarbock, G. Cagna, R. Linnepe, D. Schulte, A.F. Nottebaum and Vestweber D. (2011) Dissociation of VE-PTP from VE-cadherin is required for leukocyte extravasation and for VEGF-induced vascular permeability in vivo. J. Exp. Med. 208:2393-2401
D. Schulte, V. Küppers, N. Dartsch, A. Broermann, H. Li, A. Zarbock, O. Kamenyeva, F. Kiefer, A. Khandoga, S. Massberg and Vestweber D. (2011) Stabilizing the VE-cadherin-catenin complex blocks leukocyte extravasation and vascular permeability. EMBO J. 30:4157-7410
M. Schnoor, F.P.L. Lai, A. Zarbock, R. Kläver, C. Polaschegg, D. Schulte, H.A. Weich, J.M. Oelkers, K. Rottner and Vestweber, D. Cortactin deficiency is associated with reduced neutrophil recruitment but increased vascular permeability in vivo. J. Exp. Med. in press
T. Kempf, A. Zarbock, C. Widera, S. Butz, A. Stadtmann, J. Rossaint, M. Bolomini-Vittori, M. Korf-Klingebiel, L.C. Napp, B. Hansen, A. Kanwischer, U. Bavendiek, G. Beutel, M. Hapke, M.G. Sauer, C. Laudanna, N. Hogg, D. Vestweber* and K.C. Wollert* (2011) GDF15, an inhibitor of leukocyte integrin activation required for survival after myocardial infarction. Nat. Med. 17:581-588
*D.V. and K.C.W. are shared corresponding authors
M.G. Bixel, H. Li, B. Petri, A.G. Khandoga, A. Khandoga, A. Zarbock, K. Wolburg-Buchholz, H. Wolburg, L. Sorokin, D. Zeuschner, S. Maerz, S. Butz, F. Krombach and D. Vestweber (2010) CD99 and CD99L2 act at the same site as, but independently of, PECAM-1 during leukocyte diapedesis. Blood 116:1172-1184
B. Petri, A. Broermann, H. Li, A.G. Khandoga, A. Zarbock, F. Krombach, T. Goerge, S.W. Schneider, C. Jones, B. Nieswandt, M.K. Wild and D. Vestweber (2010) Von Willebrand factor promotes leukocyte extravasation. Blood 116:4712-4719
M. Winderlich, L. Keller, G. Cagna, A. Broermann, O. Kamenyeva, F. Kiefer, U. Deutsch, A. Nottebaum and D. Vestweber (2009) VE-PTP controls blood vessel development by balancing Tie-2 activity. J. Cell Biol. 185:657-671
C. Wu, F. Ivars, P. Anderson, R. Hallmann, D. Vestweber, P. Nilsson, H. Robenek, K. Tryggvason, J. Song, E. Korpos, K. Loser, S. Beissert, E. Georges-Labouesse and L. Sorokin (2009) Endothelial Basement Membrane Laminin α5 Selectively Inhibits T Lymphocyte Extravasation Into the Brain. Nat. Med. 15:519-527
A. Tanne, B. Ma, F. Boudou, L. Tailleux, H. Botella, E. Badell, F. Levillain, M.E. Taylor, K. Drickamer, J. Nigou, K.M. Dobos, G. Puzo, D. Vestweber, M.K. Wild, M. Marcinko, P. Sobieszczuk, L. Stewart, D. Lebus, B. Gicquel and O.A. Neyrolles (2009) murine DC-SIGN homologue contributes to early host defense against Mycobacterium tuberculosis. J. Exp. Med. 206:2205-2220
T. Yokota, K. Oritani, S. Butz, K. Kokame, P.W. Kincade, T. Miyata, D. Vestweber and Y. Kanakura (2009) The endothelial antigen ESAM marks primitive hematopoietic progenitors throughout life in mice. Blood 113: 2914-2923
A.G. Ooi, H. Karsunky, R. Majeti, S. Butz, D. Vestweber, T. Ishida, T. Quertermous, I.L. Weissman and E.C. Forsberg (2009) The Adhesion Molecule ESAM1 is A Novel Hematopoietic Stem Cell Marker. Stem Cells 27:653-661
A.F. Nottebaum, G. Cagna, M. Winderlich, A.C. Gamp, R. Linnepe, C. Polaschegg, K. Filippova, R. Lyck, B. Engelhardt, O. Kamenyeva, M.G. Bixel, S. Butz and D. Vestweber (2008) VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF. J. Exp. Med. 205: 2929-2945
D. Frommhold, A. Ludwig, M.G. Bixel, A. Zarbock, I. Babushkina, M. Weissinger, S. Cauwenberghs, L.G. Ellies, J.D. Marth, A.G. Beck-Sickinger, M. Sixt, B. Lange-Sperandio, A. Zernecke, E. Brandt, C. Weber, D. Vestweber, K. Ley and M. Sperandio (2008) Sialyltransferase ST3Gal-IV controls CXCR2-mediated firm leukocyte arrest during inflammation. J. Exp. Med. 205:1435-1446
P. Saharinen, L. Eklund, J. Miettinen, R. Wirkkala, A. Anisimov, M. Winderlich, A. Nottebaum, D. Vestweber, U. Deutsch, G.Y. Koh, B.R. Olsen and K. Alitalo (2008) Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts. Nat Cell Biol. 10:527-537
P.Turowski, R. Martinelli, R. Crawford, D. Wateridge, A.-P. Papagiorgiou, M.G. Lampugnani, A.C. Gamp, D. Vestweber, P. Adamson, E. Dejana and J. Greenwood (2008) Phosphorylation of Vascular Endothelial Cadherin Controls Lymphocyte Emigration. J. Cell Sci. 121: 29-37
M.G. Bixel, B. Petri, A.G. Khandoga, A. Khandoga, K. Wolburg-Buchholz, H. Wolburg, S. Marz, F. Krombach and D. Vestweber (2007) A CD99-related antigen on endothelial cells mediates neutrophil, but not lymphocyte extravasation. Blood 109: 5327-5336
A. Hidalgo, A.J. Peired, M. Wild, D. Vestweber and P.S. Frenette (2007) Complete identification of E-selectin ligand activity on neutrophils reveals a dynamic interplay and distinct functions of PSGL-1, ESL-1 and CD44. Immunity 26: 477-489
P. Baluk, J. Fuxe, H. Hashizume, T. Romano, E. Lashnits, S. Butz, D. Vestweber, M. Corada, C. Molendini, E. Dejana and D.M. McDonald (2007) Functionally specialized junctions between endothelial cells of lymphatic vessels. J. Exp. Med. 204: 2349-2362
M.G. Bixel, B. Petri, A.G. Khandoga, A. Khandoga, K. Wolburg-Buchholz, H. Wolburg, S. Marz, F. Krombach and D. Vestweber (2007) A CD99-related antigen on endothelial cells mediates neutrophil, but not lymphocyte extravasation. Blood 109: 5327-5336
F. Wegmann, B. Petri, A.G. Khandoga, C. Moser, A. Khandoga, S. Volkery, H. Li, I. Nasdala, O. Brandau, R. Fässler, S. Butz, F. Krombach and D. Vestweber (2006) ESAM supports neutrophil extravasation, activation of Rho and VEGF-induced vascular permeability. J. Exp. Med. 203:1671-1677
S. Baumer, L. Keller, A. Holtmann, R. Funke, B. August, A. Gamp, H. Wolburg, K. Wolburg-Buchholz, U. Deutsch and D. Vestweber (2006) Vascular endothelial cell specific phospho-tyrosine phosphatase (VE-PTP) activity is required for blood vessel development. Blood 107:4754-4762
U. Baumeister, R. Funke, K. Ebnet, H. Vorschmitt, S. Koch and D. Vestweber (2005) Association of Csk to VE-cadherin and inhibition of cell proliferation. EMBO J. 24:1686-1695
A. Matsubara, A. Iwama, Y. Yamada, S. Yamazaki, C. Furuta, R. Hirasawa, Y. Morita, M. Osawa, T. Motohashi, K. Eto, H. Ema, T. Kitamura, D. Vestweber and H. Nakauchi (2005) Expression of Endomucin, a CD34-like sialomucin, marks definitive hematopoietic stem cells from their development through life. J. Exp. Med. 202:1483-1492
A.A. Dorner, F. Wegmann, S. Butz, K. Wolburg-Buchholz, H. Wolburg, A. Mack, I. Nasdala, B. August, J. Westermann, F.G. Rathjen and D. Vestweber (2005) Coxsackievirus-Adenovirus-Receptor (CAR) is essential for early embryonic cardiac development. J. Cell Sci. 118:3509-3521
G. Bixel, S. Kloep, S. Butz, B. Petri, B. Engelhardt and D. Vestweber (2004) Mouse CD99 participates in T cell recruitment into inflamed skin. Blood 104:3205-3213
P. Vajkoczy, S. Blum, M. Lamparter, R. Mailhammer, R. Erber, B. Engelhardt, D. Vestweber and A. K. Hatzopoulos (2003) Multistep nature of microvascular recruitment of ex vivo expanded embryonic endothelial progenitor cells during tumor angiogenesis. J. Exp. Med. 197:1755-1765
R. Nawroth, G. Poell, A. Ranft, S. Kloep, U. Samulowitz, G. Fachinger, M. Golding, D.T. Shima, U. Deutsch, and D. Vestweber (2002) VE-PTP and VE-cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts. EMBO J. 21: 4885-4895
K. Lühn, M.K. Wild, M. Eckhardt, R. Gerardy-Schahn and D. Vestweber (2001) The defective gene in leukocyte adhesion deficiency II codes for a GDP-fucose transporter. Nat. Genet. 28:69-72
K. Ebnet, A. Suzuki, Y. Horikoshi, T. Hirose, M.-K. Meyer-zu-Brickwedde, S. Ohno and D. Vestweber (2001) The cell polarity protein ASIP/PAR-3 directly associates with Junctional Adhesion Molecule (JAM). EMBO J. 20: 3738-3748 (2001)
W. Baumgartner, P. Hinterdorfer, W. Ness, A. Raab, D. Vestweber, H. Schindler, and D. Drenckhahn (2000) Cadherin interaction probed by atomic force microscopy. Proc. Natl. Acad. Sci. USA 97:4005-4010
T. Marquardt, K. Lühn, G. Srikrishna, H.H. Freeze, E. Harms, and D. Vestweber (1999) Correction of Leukocyte Adhesion Deficiency Type II with oral fucose. Blood 94:3976-3985
S.M. Morgan, U. Samulowitz, L. Darley, D.L. Simmons, and D. Vestweber (1999) Biochemical characterization and molecular cloning of a novel endothelial specific sialomucin. Blood 93: 165-175
T. Moll, E. Dejana, and D. Vestweber (1998) In vitro degradation of endothelial catenins by a neutrophil protease. J. Cell Biol. 140:403-407
J. Alferink, A. Tafuri, D. Vestweber, R. Hallmann, G.J. Hämmerling, and B. Arnold (1998) Control of neonatal tolerance to tissue-antigens by peripheral T cell trafficking. Science 282: 1338-1341
F. Austrup, D. Vestweber, E. Borges, M. Löhning, R. Bräuer, R. Hallmann, A. Scheffold, A. Radbruch, and A. Hamann (1997) P- and E-selectin mediate recruitment of T helper 1 but not of T helper 2 cells into inflamed tissues. Nature 385, 81-83
O. Zöllner, M.C. Lenter, J.E. Blanks, E. Borges, M. Steegmaier, H.-G. Zerwes, and D. Vestweber (1997) L-selectin from human but not from mouse neutrophils binds directly to E-selectin. J. Cell Biol. 136, 707-715
E. Borges, W. Tietz, M. Steegmaier, T. Moll, R. Hallmann, A. Hamann, and D. Vestweber (1997) PSGL-1 on T helper 1 but not on T helper 2 cell binds to P-selectin and supports migration into inflamed skin. J. Exp. Med. 185: 573-578
E. Borges, R. Eytner, T. Moll, M. Steegmaier, MA Campbell, K. Ley, H. Mossmann, and D. Vestweber (1997) The P-selectin glycoprotein ligand-1 is important for recruitment of neutrophils into inflamed mouse peritoneum. Blood 90: 1934-1942
M. Steegmaier, E. Borges, J. Berger, H. Schwarz, and D. Vestweber (1997) The E-selectin ligand ESL-1 is located in the Golgi as well as on microvilli on the cell surface. J. Cell Science. 110: 687-694
O. Zöllner, and D. Vestweber (1996) The E-selectin Ligand-1 is selectively activated in CHO cells by the α(1,3)-Fucosyltransferase IV and VII. J. Biol. Chem. 271: 33002-33008
E.J. Kunkel, U. Jung, D.C. Bullard, K.E. Norman, B.A. Wolitzky, D. Vestweber, A.L. Beaudet and K. Ley (1996) Absence of Trauma-induced leukocyte rolling in mice deficient in both P-selectin and ICAM-1. J. Exp. Med. 183: 57-65
G. Breier, F. Breviario, L. Caveda, R. Berthier, H. Schnürch, U. Gotsch, D. Vestweber, W. Risau and E. Dejana (1996) Molecular cloning and expression of murine Vascular Endothelial Cadherin in early stage development of cardiovascular system. Blood 87: 630-641
M. Steegmaier, A. Levinovitz, S. Isenmann, E. Borges, M. Lenter, H. Kocher, B. Kleuser and D. Vestweber (1995) The E-selectin-ligand ESL-1 is a variant of a receptor for fibroblast growth factor. Nature 373: 615-620
K. Ley, D. Bullard, M.L. Arbones, R. Bosse, D. Vestweber, T. Tedder and A. Beaudet (1995) Sequential contribution of P- and L-selectin to leukocyte rolling in vivo. J. Exp. Med. 181: 669-675
R. Bosse and D. Vestweber (1994) Only blocking of L- and P-selectin completely blocks neutrophil migration into mouse peritoneum. Eur. J. Immunol. 24: 3019-3024
M. Lenter and D. Vestweber (1994) The integrin chains β1 and a6 associate with the chaperone calnexin prior to integrin assembly. J. Biol. Chem. 269: 12263 - 12268
M. Lenter, A. Levinovitz, S. Isenmann and D. Vestweber (1994) Monospecific and common glycoprotein ligands for E- and P-selectin on myeloid cells. J. Cell Biol. 125: 471 - 481
M. Lenter, H. Uhlig, A. Hamann, P. Jenö, B. Imhof and D. Vestweber (1993) A monoclonal antibody against an activation epitope on mouse integrin chain β1 blocks adhesion of lymphocytes to the endothelial integrin a6β1. Proc. Natl. Acad. Sci. USA 90: 9051-9055
A. Levinovitz, J. Mühlhoff, S. Isenmann and D. Vestweber (1993) Identification of a glycoprotein ligand for E-selectin on mouse myeloid cells. J. Cell Biol. 121, 449-459 (1993)
M. Hahne, U. Jäger, S. Isenmann, R. Hallmann and D. Vestweber (1993) Five TNF-inducible cell adhesion mechanisms on the surface of mouse endothelioma cells mediate the binding of leukocytes. J. Cell Biol. 121: 655-664
A. Weller, S. Isenmann and D. Vestweber (1992) Cloning of the mouse endothelial selectins: Expression of both E- and P-selectin is inducible by tumor necrosis factor a. J. Biol. Chem. 267: 15176-15183
K.P. Baker, A. Schaniel, D. Vestweber and G. Schatz (1990) A yeast mitochondrial outer membrane protein essential for protein import and cell viability. Nature 348: 605-609
P.E. Scherer, U.C. Krieg, S.T. Hwang, D. Vestweber and G. Schatz (1990) A precursor protein partly translocated into yeast mitochondria is bound to a 70kD mitochondrial stress protein. EMBO J. 9: 4315-4322
D. Vestweber and G. Schatz (1989) Blockage and quantification of mitochondrial protein import sites by an internally crosslinked hybrid precursor protein. Nova acta Leopoldina 61: 409-416
D. Vestweber and G. Schatz (1989) DNA-protein conjugates can enter mitochondria via the protein import pathway. Nature 338: 170-172
D. Vestweber, J. Brunner, A. Baker and G. Schatz (1989) A 42K outer membrane protein is a component of the yeast mitochondrial protein import site. Nature 341: 205-209
D. Vestweber and G. Schatz (1988) Point mutations destabilizing a precursur protein enhance its post-translational import into mitochondria. EMBO J. 7: 1147-1151
D. Vestweber and G. Schatz (1988) Mitochondria can import artificial precursor proteins containing a branched polypeptide chain or a carboxy-terminal stilbene disulfonate J. Cell Biol. 107: 2045-2049
D. Vestweber and G. Schatz (1988) A chimeric mitochondrial precursor protein with internal disulfide bridges blocks import of authentic precursors into mitochondria and allows quantitation of import sites. J. Cell Biol. 107: 2037-2043
M. Ringwald, R. Schuh, D. Vestweber, H. Eistetter, F. Lottspeich, J. Engel, R. Dölz, F. J. Jähnig, J. Epplen, S. Mayer, C. Müller and R. Kemler (1987) The structure of cell adhesion molecule uvomorulin. Insights into the molecular mechanism of calcium dependent cell adhesion. EMBO J. 6: 3647-3653
D. Vestweber, A. Gossler, K. Boller and R. Kemler (1987) Expression and distribution of cell adhesion molecule uvomorulin in mouse preimplantation embryos Dev. Biol. 124: 451-456
R. Schuh, D. Vestweber, I. Riede, U.B. Rosenberg, H. Jäckle and R. Kemler (1986) Molecular cloning of mouse cell adhesion molecule uvomorulin: cDNA contains a B1 related sequence. Proc. Natl. Acad. Sci. USA 83: 1364-1368
D. Vestweber and R. Kemler (1985) Identification of a putative cell adhesion domain of uvomorulin. EMBO J. 4: 3393-3398
D. Vestweber, R. Kemler and P. Ekblom (1985) Cell adhesion molecule uvomorulin during kidney development. Dev. Biol. 112: 213-221
D. Vestweber, C. Ocklind, A. Gossler, P. Odin, B. Öbrink and R. Kemler (1985) Comparison of two cell adhesion molecules, uvomorulin and cell-CAM 105. Exp. Cell Res. 157: 451-461
K. Boller, D. Vestweber and R. Kemler (1985) Cell adhesion molecule uvomorulin is localized in the indermediate junctions of adult intestinal epithelial cells. J. Cell Biol. 100: 327-332
D. Vestweber and R. Kemler (1984) Rabbit antiserum against a purified surface glycoprotein decompacts mouse preimplantation embryos and reacts with specific adult tissues. Exp. Cell Res. 152: 169-178
D. Vestweber and R. Kemler (1984) Some structural and functional aspects of the cell adhesion molecule uvomorulin. Cell Differentiation 15: 269-273
