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Department Vascular Cell Biology
Director: Prof. Dr. Dietmar Vestweber

Selected publications since 1995:

Winderlich M., Keller L., Cagna G., Broermann A., Kamenyeva O., Kiefer F., Deutsch U., Nottebaum A., Vestweber D.:
VE-PTP controls blood vessel development by balancing Tie-2 activity.
J. Cell Biol. In press

Wu C., Ivars F., Anderson P., Hallmann R., Vestweber D., Nilsson P., Robenek H., Tryggvason K., Song J., Korpos E., Loser K., Beissert S., Georges-Labouesse, Sorokin L.:
Endothelial Basement Membrane Laminin α5 Selectively Inhibits T Lymphocyte Extravasation Into the Brain.
Nat. Med. in press

Labelle M., Schnittler H.J., Aust D.E., Friedrich K., Baretton G., Vestweber D., Breier G.:
Vascular endothelial cadherin promotes breast cancer progression via transforming growth factor beta signaling.
Cancer Res. 68:1388-97 (2008)

Caffaro C.E., Luhn K., Bakker H., Vestweber D., Samuelson J., Berninsone P., Hirschberg C.B.:
A Single Caenorhabditis elegans Golgi Apparatus-Type Transporter of UDP-Glucose, UDP-Galactose, UDP-N-Acetylglucosamine, and UDP-N-Acetylgalactosamine.
Biochemistry. 47: 4337-4344 (2008)

Saharinen P., Eklund L., Miettinen J., Wirkkala R., Anisimov A., Winderlich M., Nottebaum A., Vestweber D., Deutsch U., Koh G.Y., Olsen B.R., Alitalo K.:
Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts.
Nat Cell Biol. 10:527-537 (2008)

Frommhold, D., Ludwig, A., Bixel, M.G., Zarbock, A., Babushkina, I., Weissinger, M., Cauwenberghs, S., Ellies, L.G., Marth, J.D., Beck-Sickinger, A.G., Sixt, M., Lange-Sperandio, B., Zernecke, A., Brandt, E., Weber, C., Vestweber, D., Ley, K., and Sperandio, M.:
Sialyltransferase ST3Gal-IV controls CXCR2-mediated firm leukocyte arrest during inflammation.
J. Exp. Med. 205:1435-1446 (2008)

Pfeiffer, F., Kumar, V., Butz, S., Vestweber D., Imhof, B.A., Stein J.V., Engelhardt, B.:
Distinct molecular composition of blood and lymphatic vascular endothelial cell junctions establishes specific functional barriers within the peripheral lymph node.
Eur. J. Immunol. 38:2142-55 (2008)

Nottebaum AF, Cagna G, Winderlich M, Gamp AC, Linnepe R, Polaschegg C, Filippova K, Lyck R, Engelhardt B, Kamenyeva O, Bixel MG, Butz S, Vestweber D. :
VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF.
J. Exp. Med. in pess (2008)

Vestweber D, Wild M.:
A new player in lymphocyte homing.
Nat Immunol. 9: 347-8 (2008) (News and Views)

Turowski P., R. Martinelli, R. Crawford, D. Wateridge, .-P- Papagiorgiou, M.G. Lampugnani, A.C. Gamp, D. Vestweber, P. Adamson, E. Dejana E and J. Greenwood:
Phosphorylation of Vascular Endothelial Cadherin Controls Lymphocyte Emigration.
J. Cell Sci. 121: 29-37 ( 2008)

Riethmuller C., I. Nasdala and D. Vestweber:
Nano-surgery at the leukocyte-endothelial docking site.
Pflugers Arch. (Eur. J. Physiol.) 456: 71-81 (2008)

Vestweber D.:
VE-cadherin: the major endothelial adhesion molecule controlling cellular junctions and blood vessel formation.
Arterioscl. Thromb.Vasc. Biol. In press (2008)

Vestweber D.:
Adhesion and signaling molecules controlling the transmigration of leukocytes through endothelium.
Immunological Reviews, 218: 178-196 (2007)

Filser C., D. Kowalczyk, C. Jones, M.K. Wild, D. Vestweber and H. Kunz:
Synthetic glycopeptides from E-slectin-ligand1 with modified Sialyl-Lewisx structure as cell adhesion inhibitor of E-selectin.
Angew Chem Int Ed Engl 46: 2108-2111 (2007)

Bixel M.G., B. Petri, A.G. Khandoga, A. Khandoga, K. Wolburg-Buchholz, H. Wolburg, S. Marz, F. Krombach and D. Vestweber D:
A CD99-related antigen on endothelial cells mediates neutrophil, but not lymphocyte extravasation.
Blood 109: 5327-5336 (2007)

Hidalgo A., A.J. Peired, M.K. Wild, D. Vestweber and P.S. Frenette PS:
Complete identification of E-selectin ligand activity on neutrophils reveals a dynamic interplay and distinct functions of PSGL-1, ESL-1 and CD44.
Immunity 26: 477-489 (2007)

Baluk P., J. Fuxe, H. Hashizume, T. Romano, E. Lashnits, S. Butz, D. Vestweber, M. Corada, C. Molendini, E. Dejana and D.M. McDonald:
Functionally specialized junctions between endothelial cells of lymphatic vessels.
J. Exp. Med. 204: 2349-62 (2007)

Döring A., M.K. Wild, D. Vestweber, U. Deutsch and B. Engelhardt:
E- and P-Selectin are not required for the development of experimental autoimmune encephalomyelitis in C57Bl/6 and SJL mice.
J. Immunol. 179: 8470-8479 (2007)

Urzainqui A., G. Martínez del Hoyo, A. Lamana A, H. de la Fuente, O. Barreiro, I.M. Olazábal, P. Martin, M.K. Wild and D. Vestweber D: González-Amaro R, Sánchez-Madrid F.:
Functional role of PSGL-1/P-Selectin interaction in the generation of tolerogenic dendritic cells.
J. Immunol. 179:7457-7465 (2007)

Varga G., S. Balkow, M.K. Wild, A. Stadtbaeumer, M. Krummen, T. Rothoeft, T. Higuchi, S. Beissert, K. Wethmar, K. Scharffetter-Kochanek, D. Vestweber and S. Grabbe:
Active Mac-1 (CD11b/CD18) on DC is inhibitory for full T cell activation.
Blood 109: 661-9 (2007)

Helmus Y, J. Denecke, S. Yakubenia, P. Robinson, K. Lühn, D.L. Watson, P.J. McGrogan, D. Vestweber, T. Marquardt and M.K. Wild:
Leukocyte adhesion deficiency II patients with a dual defect of the GDP-fucose transporter.
Blood 107:3959-66 (2006)

Baumer S., L. Keller, A. Holtmann, R. Funke, B. August, A. Gamp, H. Wolburg, K. Wolburg-Buchholz, U. Deutsch and D. Vestweber:
Vascular endothelial cell specific phospho-tyrosine phosphatase (VE-PTP) activity is required for blood vessel development.
Blood 107:4754-62 (2006)

Wegmann F., B. Petri, A.G. Khandoga, C. Moser, A. Khandoga, S. Volkery, H. Li, I. Nasdala, O. Brandau, R. Fässler, S. Butz, F. Krombach and D. Vestweber D:
ESAM supports neutrophil extravasation, activation of Rho and VEGF-induced vascular permeability.
J. Exp. Med. 203:1671-1677 (2006)

Nören-Müller A., I. Reis Corrêa, H. Prinz, C. Rosenbau, K. Saxena, H. Schwalbe, D. Vestweber, G. Cagna, S. Schunk, O. Schwarz, H. Schiewe and H. Waldmann:
Discovery of New Protein Phosphatase Inhibitor Classes by Biology Oriented Synthesis (BIOS).
Proc. Natl. Acad. Sci. USA 103: 10606-10611 (2006)

Wethmar K., Y. Hellmus, K. Luhn, C. Jones, A. Laskowska, G. Varga, S. Grabbe, R. Lyck, B. Engelhardt, G. Bixel, S. Butz, K. Loser, S. Beissert, U. Ipe, D. Vestweber and M.K. Wild:
Migration of immature mouse dendritic cells across resting endothelium is mediated by ICAM-2 but independent of β2-integrins and murine DC-SIGN homologs.
Eur. J. Immunol. 36: 2781-94. (2006)

Iden S., D. Rehder, B. August, A. Suzuki, K. Wolburg-Buchholz, H. Wolburg, S. Ohno, J. Behrens, D. Vestweber and K. Ebnet:
A distinct PAR protein complex physically associated with VE-cadherin in vertebrate endothelial cells.
EMBO Rep. 7:1239-46 (2006)

Baumeister, U., R. Funke, K. Ebnet, H. Vorschmitt, S. Koch and D. Vestweber:
Association of Csk to VE-cadherin and inhibition of cell proliferation.
EMBO J. 24:1686-1695 (2005)

Dorner, A.A., F. Wegmann, S. Butz, K. Wolburg-Buchholz, H. Wolburg, A. Mack, Nasdala I, August B, Westermann J, Rathjen FG, Vestweber D.:
Coxsackievirus-Adenovirus-Receptor (CAR) is essential for early embryonic cardiac development.
J. Cell Sci. 118:3509-3521 (2005)

Engelhardt B., B. Kempe, S. Merfeld-Clauss, M. Laschinger, B. Furie, M.K. Wild and D. Vestweber:
P-Selectin Glycoprotein Ligand 1 Is Not Required for the Development of Experimental Autoimmune Encephalomyelitis in SJL and C57BL/6 Mice.
J Immunol. 175:1267-75 (2005)

Matsubara A., A. Iwama, Y. Yamada, S, Yamazaki, C. Furuta, R. Hirasaw, Y. Morita, M. Osawa, T. Motohashi, K. Eto, H. Ema, T. Kitamura, D. Vestweber and H. Nakauchi:
Expression of Endomucin, a CD34-like sialomucin, marks definitive hematopoietic stem cells from their development through life.
J. Exp. Med. 202:1483-1492 (2005)

Schwarz, A., A. Maeda, M.K. Wild, K. Kernebeck, N. Gross, Y. Aragane, S. Beissert, D. Vestweber and T. Schwarz:
UV-induced regulatory T cells do not only inhibit the induction but can also suppress the effector phase of contact hypersensitivity.
J. Immunol. 172:1036-1043 (2004)

Combes, V., A.R. Rosenkranz, M. Redard, G. Pizzolato, H. Lepidi, D. Vestweber, T.N. Mayadas and G.E. Grau:
Pathogenic role of P-selectin in experimental cerebral malaria: importance of the endothelial compartment.
Am J Pathol. 164:781-6 (2004)

Wegmann, F., K. Ebnet, L. Du Pasquier, D. Vestweber and S. Butz:
Endothelial adhesion molecule ESAM binds directly to the multidomain adaptor MAGI-1 and recruits it to cell contacts.
Exp. Cell Res. 300:121-133 (2004)

Bixel, G., S. Kloep, S. Butz, B. Petri, B. Engelhardt and D. Vestweber:
Mouse CD99 participates in T cell recruitment into inflamed skin.
Blood 104:3205-13 (2004)

Ebnet, K., A. Suzuki, S. S. Ohno and Vestweber, D:
Junctional adhesion molecules (JAMs): more molecules with dual functions?
J. Cell Sci. 117:19-29 (2004)

Vajkoczy, P., S. Blum, M. Lamparter, R. Mailhammer, R. Erber, B. Engelhardt, D. Vestweber and A. K. Hatzopoulos:
Multistep nature of microvascular recruitment of ex vivo expanded embryonic endothelial progenitor cells during tumor angiogenesis.
J. Exp. Med. 197:1755-1765 (2003)

Katayama, Y., A. Hidalgo, B.C. Furie , D. Vestweber, B. Furie, and P.S. Frenette:
PSGL-1 participates in E-selectin-mediated progenitor homing to bone marrow: evidence for cooperation between E-selectin ligands and α4-integrin.
Blood 102:2060-2067 (2003)

Ebnet, K., M. Aurrand-Lions, A. Kuhn, F. Kiefer, S. Butz, K. Zander, M.-K. Meyer zu Brickwedde, A. Suzuki, B. Imhof, and D. Vestweber:
The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: A possible role for JAMs in endothelial polarity.
J. Cell Sci. 116:3879-3891 (2003)

Wild, M.K., K. Luhn, T. Marquardt and D.Vestweber:
Leukocyte Adhesion Deficiency II: Therapy and Genetic Defect.
Cells Tissues Organs. 172:161-73 (2002)

Vestweber D.:
Regulation of endothelial cell contacts during leukocyte extravasation.
Curr. Opin. Cell Biol. 14: 587-593 (2002)

Pendl, G., C. Robert, M. Steinert, R. Thanos, R. Eytner, E. Borges, M. K.Wild, J. B. Lowe, R. C. Fuhlbrigge, T. S. Kupper, D. Vestweber, S. Grabbe:
Immature Mouse Dendritic Cells Enter Inflamed Tissue, a Process that requires E- and P-selectin, but not PSGL-1.
Blood 99: 946-956 (2002)

Nasdala, I., K. Wolburg-Buchholz, H. Wolburg, A. Kuhn, K. Ebnet, G. Brachtendorf, U. Samulowitz, B. Kuster, B. Engelhardt, D. Vestweber and S. Butz:
A transmembrane tight junction protein selectively expressed on endothelial cells and platelets.
J. Biol. Chem. 277: 16294-16303 (2002)

Samulowitz, U., A. Kuhn, G. Brachtendorf, R. Nawroth, A. Braun, A. Bankfalvi, W. Böcker, and D. Vestweber:
Human endomucin: distribution pattern, expression on high endothelial venules and decoration with the MECA-79 epitope.
Am. J. Pathol. 160: 1669-1681 (2002)

Nawroth, R., G. Poell, A. Ranft, S. Kloep, U. Samulowitz, G. Fachinger, M. Golding, D.T. Shima, U. Deutsch, and D. Vestweber:
VE-PTP and VE-cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts.
EMBO J. 21: 4885-4895 (2002)

Huang, M.-C., A. Laskowska, D. Vestweber, and M.K. Wild:
The (1,3)-fucosyltransferase Fuc-TIV, but not Fuc-TVII, generates sialyl Lewis X-like epitopes preferentially on glycolipids.
J. Biol. Chem. 277:47786-95 (2002)

Lühn, K., T. Marquardt, E. Harms, and D. Vestweber:
Discontinuation of fucose therapy in LADII causes rapid loss of selectin ligands and rise of leukocyte counts.
Blood 97:330-332 (2001)

Lühn, K., M.K. Wild, M. Eckhardt, R. Gerardy-Schahn, D. Vestweber:
The defective gene in leukocyte adhesion deficiency II codes for a GDP-fucose transporter.
Nat. Genet. 28:69-72 (2001)

Ebnet, K., A. Suzuki, Y. Horikoshi, T. Hirose, M.-K. Meyer-zu-Brickwedde, S. Ohno, D. Vestweber:
The cell polarity protein ASIP/PAR-3 directly associates with Junctional Adhesion Molecule (JAM).
EMBO J. 20: 3738-3748 (2001)

Wild, M.K., M.-C. Huang, U. Schulze-Horsel, P. A. van der Merwe, D. Vestweber:
Affinity, kinetics and thermodynamics of E-selectin binding to E-selectin ligand-1.
J. Biol. Chem. 276:31602-31612 (2001)

Brachtendorf, G., A. Kuhn, U. Samulowitz, R. Knorr, E. Gustaffson, A.J. Potocnik, R. Fässler, D. Vestweber:
Early expression of endomucin on endothelium of the mouse embryo and on putative hematopoetic clusters in the dorsal aorta.
Dev. Dynam. 222:410-419 (2001)

Rosch, M., H. Herzner, W. Dippold, M. Wild, D. Vestweber, H. Kunz:
Synthetic Inhibitors of Cell Adhesion: A Glycopeptide from E-Selectin Ligand 1 (ESL-1) with the Arabino Sialyl Lewis(x) Structure.
Angew Chem Int Ed Engl 40:3836-3839 (2001)

Frenette, P., C.V. Denis, L. Weiss, K. Jurk, S. Subbarao, B. Kehrel, J.H. Hartwig, D. Vestweber, and D.D. Wagner:
P-selectin glycoprotein ligand-1 (PSGL-1) is expressed on platelets and can mediate platelet-endothelial ineractions in vivo.
J. Exp. Med. 191:1413-1422 (2000)

Baumgartner, W., P. Hinterdorfer, W. Ness, A. Raab, D. Vestweber, H. Schindler, and D. Drenckhahn:
Cadherin interaction probed by atomic force microscopy.
Proc. Natl. Acad. Sci. USA 97:4005-4010. (2000)

Ebnet, K., C. U. Schulz, M.-K. Meyer-zu Brickwedde, G. G. Pendl, and D. Vestweber:
Junctional Adhesion Molecule (JAM) interacts with the PDZ domain containing proteins AF-6 and ZO-1.
J. Biol. Chem. 275:27979-27988 (2000)

Huang, M.-C., O. Zöllner, T. Moll, P. Maly, A. D.Thall, J. B. Lowe, and D. Vestweber:
P selectin glycoprotein ligand-1 and E-selectin ligand-1 are differentially modified by fucosyltransferases Fuc-TIV and Fuc-TVII in mouse neutrophils.
J. Biol. Chem. 275:31353-31360 (2000)

Vestweber D:
Molecular mechanisms that control endothelial cell contacts.
J. Pathol. 190:281-291 (2000)

Engelhardt, B., M. Laschinger, M. Schulz, U. Samulowitz, D. Vestweber, and G. Hoch:
a4-integrin but not a4b 7-integrin is required for the development of experimental autoimmune encephalomyelitis in the mouse: evidence for a role in T cell activation and recruitment.
J. Clin. Invest. 102: 2096-2105 (1999)

Marquardt, T., T. Brune, K. Lühn, P. Zimmer, C. Körner, L. Fabritz, N. van der Werft, J. Vormoor, H.H. Freeze, F. Louwen, B. Biermann, E. Harms, K. von Figura, D. Vestweber, and H.G. Koch:
A new patient with Leukocyte Adhesion Deficiency (LAD) II Syndrome.
J. Pediatr. 134: 681-688 (1999)

Marquardt, T., K. Lühn, G. Srikrishna, H.H. Freeze, E. Harms, and D. Vestweber:
Correction of Leukocyte Adhesion Deficiency Type II with oral fucose.
Blood, 94:3976-3985 (1999)

Vestweber D and Blanks J:
Mechanisms that regulate the function of the selectins and their ligands.
Physiol. Rev. 79: 181-213 (1999)

Vestweber D:
Selectin ligands. In: Guidebook to the Extacellular Matrix and Adhesion Proteins R. Vale and T. Kreis, editors,
Oxford University Press 237-256 (1999)

Morgan, S.M., U. Samulowitz, L. Darley, D.L. Simmons, and D. Vestweber:
Biochemical characterization and molecular cloning of a novel endothelial specific sialomucin.
Blood, 93: 165-175 (1999)

Blanks, J.E., T. Moll, R. Eytner, and D. Vestweber:
Stimulation of P-selectin glycoprotein ligand-1 onmouse neutrophils activates b 2-integrin mediated cell attachment to ICAM-1.
Eur. J. Immunol. 28:433-443 (1998)

Moll, T., E. Dejana, and D. Vestweber:
In vitro degradation of endothelial catenins by a neutrophil protease.
J. Cell Biol. 140:403-407 (1998)

Alferink, J., A. Tafuri, D. Vestweber, R. Hallmann, G.J. Hämmerling, and B. Arnold:
Control of neonatal tolerance to tissue-antigens by peripheral T cell trafficking.
Science, 282: 1338-1341 (1998)

Zöllner, O., M.C. Lenter, J.E. Blanks, E. Borges, M. Steegmaier, H.-G. Zerwes, and D. Vestweber:
L-selectin from human but not from mouse neutrophils binds directly to E-selectin.
J. Cell Biol. 136, 707-715 (1997)

Gotsch, U., E. Borges, R. Bosse, E. Böggemeyer, M. Simon, H. Mossmann, and D. Vestweber:
VE-cadherin antibody accelerates neutrophil recruitment in vivo.
J. Cell Science. 110, 538-588 (1997)

Austrup, E., D. Vestweber, E. Borges, M. Löhning, R. Bräuer, R. Hallmann, A. Scheffold, A. Radbruch, and A. Hamann:
P- and E-selectin mediate recruitment of T helper 1 but not of T helper 2 cells into inflamed tissues.
Nature 385, 81-83 (1997)

Steegmaier, M., E. Borges, J. Berger, H. Schwarz, and D. Vestweber:
The E-selectin ligand ESL-1 is located in the Golgi as well as on microvilli on the cell surface.
J. Cell Science. 110, 687-694 (1997)

Borges, E., R. Eytner, T. Moll, M. Steegmaier, MA Campbell, K. Ley, H. Mossmann, and D. Vestweber:
The P-selectin glycoprotein ligand-1 is important for recruitment of neutrophils into inflamed mouse peritoneum.
Blood 90, 1934-1942 (1997)

Borges, E., W. Tietz, M. Steegmaier, T. Moll, R. Hallmann, A. Hamann, and D. Vestweber:
PSGL-1 on T helper 1 but not on T helper 2 cell binds to P-selectin and supports migration into inflamed skin.
J. Exp. Med. 185, 573-578 (1997)

Vestweber D. (1996):
The Selectins: Initiators of Leukocyte Endothelial Adhesion.
Harwood Academic Publisher, London.

Steegmaier, M., A. Levinovitz, S. Isenmann, E. Borges, M. Lenter, H. Kocher, B. Kleuser and D. Vestweber: i
The E-selectin-ligand ESL-1 is a variant of a receptor for fibroblast growth factor.
Nature 373:615-620 (1995)

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