Dr. Ivan Bedzhov

Tel.: +49 251 70365-370/371

Dr. Ivan Bedzhov
Dr. Ivan Bedzhov

Embryonic Self-Organization

Cracking the black box of early embryonic development

The genesis of a new organism is one of the greatest miracles of life. In mammals, the fusion of the sperm and the egg occurs in the female reproductive tract. The newly formed embryo starts dividing, increasing in cell number and complexity as it travels through the oviduct. The early stages of embryonic development can be readily recapitulated in a test tube, which has provided the foundation of modern clinical IVF techniques. This also enables the derivation of pluripotent embryonic stem cells that have the capacity to differentiate into all cell types of the body and hold a great promise for future cell replacement therapies.

Early mouse embryonic development Bild vergrößern
Early mouse embryonic development

At day four and a half after fertilization the mouse embryo reaches the uterus and initiates implantation (days 7-9 in human). In turn, the maternal tissues proliferate and engulf the embryo, making it inaccessible for direct observations and experimental manipulations. Therefore, the mammalian development at the time of implantation is largely unexplored and probably the most enigmatic period of the early embryogenesis. In a very short period of time, just within 24 hours, the hollow shaped embryo (blastocyst) radically changes its appearance, transforming into an elongated structure (egg cylinder). Proper establishment of the egg cylinder is critical as it serves as a foundation for the blueprint of the developing body. The mechanism of the blastocyst to egg cylinder transition is a long standing mystery and a major focus of our research. Using mouse embryos and embryonic stem cells as model systems we are trying to understand the process of self-organization of the embryonic tissues that dynamically acquire new shapes and functions during implantation.

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