Abteilung Gewebebiologie und Morphogenese

Publikationen

2017

Bixel MG, Kusumbe AP, Ramasamy SK, Sivaraj KK, Butz S, Vestweber D, Adams RH (2017). Flow Dynamics and HSPC Homing in Bone Marrow Microvessels. Cell Rep 18:1804-1816

2016

Chu M, Li T, Shen B, Cao X, Zhong H, Zhang L, Zhou F, Ma W, Jiang H, Xie P, Liu Z, Dong N, Xu Y, Zhao Y, Xu G, Lu P, Luo J, Wu Q, Alitalo K, Koh GY, Adams RH, He Y (2016). Angiopoietin receptor Tie2 is required for vein specification and maintenance via regulating COUP-TFII. eLife 2016;5:e21032.

Ramasamy SK, Kusumbe AP, Schiller M, Zeuschner D, Bixel MG, Milia C, Gamrekelashvili J, Limbourg A, Medvinsky A, Santoro MM, Limbourg FP, Adams RH (2016). Blood flow controls bone vascular function and osteogenesis. Nat Commun 7:13601.

Gamrekelashvili J, Giagnorio R, Jussofie J, Soehnlein O, Duchene J, Briseño CG, Ramasamy SK, Krishnasamy K, Limbourg A, Kapanadze T, Ishifune C, Hinkel R, Radtke F, Strobl LJ, Zimber-Strobl U, Napp LC, Bauersachs J, Haller H, Yasutomo K, Kupatt C, Murphy KM, Adams RH, Weber C, Limbourg FP (2016). Regulation of monocyte cell fate by blood vessels mediated by Notch signalling. Nat Commun 7:12597.

Watson EC, Whitehead L, Adams RH, Dewson G, Coultas L (2016). Endothelial cell survival during angiogenesis requires the pro-survival protein MCL1. Cell Death Differ 8:1371-9

Ramasamy SK, Kusumbe AP, Itkin T, Gur-Cohen S, Lapidot T, Adams RH (2016). Regulation of Hematopoiesis and Osteogenesis by Blood Vessel-Derived Signals. Annu Rev Cell Dev Biol 32:649-675. Epub 2016 Aug 17.

Chen Q, Zhang H, Liu Y, Adams S, Eilken H, Stehling M, Corada M, Dejana E, Zhou B, Adams RH (2016). Endothelial cells are progenitors of cardiac pericytes and vascular smooth muscle cells. Nat Commun 7:12422.

Sivaraj KK, Adams RH (2016). Blood vessel formation and function in bone. Development 143:2706-15.

Nakagawa A, Naito AT, Sumida T, Nomura S, Shibamoto M, Higo T, Okada K, Sakai T, Hashimoto A, Kuramoto Y, Oka T, Lee JK, Harada M, Ueda K, Shiojima I, Limbourg FP, Adams RH, Noda T, Sakata Y, Akazawa H, Komuro I (2016). Activation of endothelial β-catenin signaling induces heart failure. Sci Rep 6:25009

Gao F, Artham S, Sabbineni H, Al-Azayzih A, Peng XD, Hay N, Adams RH, Byzova TV, Somanath PR (2016). Akt1 promotes stimuli-induced endothelial-barrier protection through FoxO-mediated tight-junction protein turnover. Cell Mol Life Sci 73:3917-33

Shah B, Lutter D, Bochenek ML, Kato K, Tsytsyura Y, Glyvuk N, Sakakibara A, Klingauf J, Adams RH, Püschel AW (2016). C3G/Rapgef1 Is Required in Multipolar Neurons for the Transition to a Bipolar Morphology during Cortical Development. PLoS One 11:e0154174.

Kusumbe AP, Ramasamy SK, Itkin T, Andoloussi M, Langen UH, Betsholtz C, Lapidot T, Adams RH (2016). Age-dependent modulation of vascular niches for haematopoietic stem cells. Nature 532:380-4.

Mondor I, Jorquera A, Sene C, Adriouch S, Adams RH, Zhou B, Wienert S, Klauschen F, Bajénoff M (2016). Clonal Proliferation and Stochastic Pruning Orchestrate Lymph Node Vasculature RemodelingImmunity 45:877-888.

Itkin T, Gur-Cohen S, Spencer JA, Schajnovitz A, Ramasamy SK, Kusumbe AP, Ledergor G, Jung Y, Milo I, Poulos MG, Kalinkovich A, Ludin A, Kollet O, Shakhar G, Butler JM, Rafii S, Adams RH, Scadden DT, Lin CP, Lapidot T (2016). Distinct bone marrow blood vessels differentially regulate haematopoiesis. Nature 532:323-8.

Kerr BA, West XZ, Kim YW, Zhao Y, Tischenko M, Cull RM, Phares TW, Peng XD, Bernier-Latmani J, Petrova TV, Adams RH, Hay N, Naga Prasad SV, Byzova TV (2016). Stability and function of adult vasculature is sustained by Akt/ Jagged1 signalling axis in endothelium. Nat Commun 7:10960.

Nohata N, Uchida Y, Stratman AN, Adams RH, Zheng Y, Weinstein BM, Mukouyama YS, Gutkind JS (2016). Temporal-specific roles of Rac1 during vascular development and retinal angiogenesis. Dev Biol 411:183-94.

Merk H, Zhang S, Lehr T, Müller C, Ulrich M, Bibb JA, Adams RH, Bracher F, Zahler S, Vollmar AM, Liebl J (2016). Inhibition of endothelial Cdk5 reduces tumor growth by promoting non-productive angiogenesis. Oncotarget 2;7:6088-104.

2015

Kusumbe AP, Ramasamy SK, Starsichova A, Adams RH (2015). Sample preparation for high-resolution 3D confocal imaging of mouse skeletal tissue. Nat Protoc 10:1904-14.

Gerl K, Miquerol L, Todorov VT, Hugo CP, Adams RH, Kurtz A, Kurt B (2015). Inducible glomerular erythropoietin production in the adult kidney. Kidney Int 88:1345-1355.

Cuttano R, Rudini N, Bravi L, Corada M, Giampietro C, Papa E, Morini MF, Maddaluno L, Baeyens N, Adams RH, Jain MK, Owens GK, Schwartz M, Lampugnani MG, Dejana E (2015). KLF4 is a key determinant in the development and progression of cerebral cavernous malformations. EMBO Mol Med 8:6-24.

Nunan R, Campbell J, Mori R, Pitulescu ME, Jiang WG, Harding KG, Adams RH, Nobes CD, Martin P (2015). Ephrin-Bs drive junctional downregulation and actin stress fiber disassembly to enable wound re-epithelialization. Cell Rep 13:1380-95.

Adams RH (2015). MoD Special Issue on interactions at the neurovascular interface. Mech Dev Nov;138 Pt 1:1.

Sheikh AQ, Misra A, Rosas IO, Adams RH, Greif DM (2015). Smooth muscle cell progenitors are primed to muscularize in pulmonary hypertension. Sci Transl Med 7:308.

Pedrosa AR, Trindade A, Carvalho C, Graça J, Carvalho S, Peleteiro MC, Adams RH, Duarte A (2015). Endothelial Jagged1 promotes solid tumor growth through both pro-angiogenic and angiocrine functions. Oncotarget 6:24404-23.

Savant S, La Porta S, Budnik A, Busch K, Hu J, Tisch N, Korn C, Valls AF, Benest AV, Terhardt D, Qu X, Adams RH, Baldwin HS, Ruiz de Almodóvar C, Rodewald HR, Augustin HG. (2015). The Orphan Receptor Tie1 controls angiogenesis and vascular remodeling by differentially regulating Tie2 in tip and stalk cells. Cell Rep 12:1761-73.

Hong KY, Bae H, Park I, Park DY, Kim KH, Kubota Y, Cho ES, Kim H, Adams RH, Yoo OJ, Koh GY (2015). Perilipin+ embryonic preadipocytes actively proliferate along growing vasculatures for adipose expansion.  Development 142:2623-32.

Weinl C, Castaneda Vega S, Riehle H, Stritt C, Calaminus C, Wolburg H, Mauel S, Breithaupt A, Gruber AD, Wasylyk B, Olson EN, Adams RH, Pichler BJ, Nordheim A (2015). Endothelial depletion of murine SRF/MRTF provokes intracerebral hemorrhagic stroke. Proc Natl Acad Sci USA 112:9914-9.

van Lessen M, Nakayama M, Kato K, Kim JM, Kaibuchi K, Adams RH (2015). Regulation of vascular endothelial growth factor receptor function in angiogenesis by numb and numb-like.
Arterioscler Thromb Vasc Biol 35:1815-25.

Um SH, Sticker-Jantscheff M, Chau GC, Vintersten K, Mueller M, Gangloff YG, Adams RH, Spetz JF, Elghazi L, Pfluger PT, Pende M, Bernal-Mizrachi E, Tauler A, Tschöp MH, Thomas G, Kozma SC (2015). S6K1 controls pancreatic β cell size independently of intrauterine growth restriction. J Clin Invest 125:2736-47.

Bravi L, Rudini N, Cuttano R, Giampietro C, Maddaluno L, Ferrarini L, Adams RH, Corada M, Boulday G, Tournier-Lasserve E, Dejana E, Lampugnani MG (2015). Sulindac metabolites decrease cerebrovascular malformations in CCM3-knockout mice. Proc Natl Acad Sci USA 112:8421-6.

Liebl J, Zhang S, Moser M, Agalarov Y, Demir CS, Hager B, Bibb JA, Adams RH, Kiefer F, Miura N, Petrova TV, Vollmar AM, Zahler S (2015). Cdk5 controls lymphatic vessel development and function by phosphorylation of Foxc2. Nat Commun 6:7274.

Kidoya H, Naito H, Muramatsu F, Yamakawa D, Jia W, Ikawa M, Sonobe T, Tsuchimochi H, Shirai M, Adams RH, Fukamizu A, Takakura N (2015). APJ Regulates Parallel Alignment of Arteries and Veins in the Skin. Dev Cell 33:247-59.

Meguenani M, Miljkovic-Licina M, Fagiani E, Ropraz P, Hammel P, Aurrand-Lions M, Adams RH, Christofori G, Imhof BA, Garrido-Urbani S (2015). Junctional adhesion molecule B interferes with angiogenic VEGF/VEGFR2 signaling. FASEB J 29:3411-25.

Mikelis CM, Simaan M, Ando K, Fukuhara S, Sakurai A, Amornphimoltham P, Masedunskas A, Weigert R, Chavakis T, Adams RH, Offermanns S, Mochizuki N, Zheng Y, Gutkind JS (2015). RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock. Nat Commun 6:6725.

Stanczuk L, Martinez-Corral I, Ulvmar MH, Zhang Y, Laviña B, Fruttiger M, Adams RH, Saur D, Betsholtz C, Ortega S, Alitalo K, Graupera M, Mäkinen T (2015). cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels. Cell Rep 10:1708–21.

Pedrosa AR, Trindade A, Fernandes AC, Carvalho C, Gigante J, Tavares AT, Diéguez-Hurtado R, Yagita H, Adams RH, Duarte A (2015). Endothelial JAGGED1 antagonizes dll4 regulation of endothelial branching and promotes vascular maturation downstream of dll4/notch1. Arterioscler Thromb Vasc Biol 35:1134-46.

Yamamoto H, Ehling M, Kato K, Kanai K, van Lessen M, Frye M, Zeuschner D, Nakayama M, Vestweber D, Adams RH (2015). Integrin β1 controls VE-cadherin localization and blood vessel stability. Nat Commun 6:6429.

Birdsey GM, Shah AV, Dufton N, Reynolds LE, Osuna Almagro L, Yang Y, Aspalter IM, Khan ST, Mason JC, Dejana E, Göttgens B, Hodivala-Dilke K, Gerhardt H, Adams RH, Randi AM (2015). The endothelial transcription factor ERG promotes vascular stability and growth through Wnt/β-catenin signaling. Dev Cell 32:82-96.

Ramasamy SK, Kusumbe AP, Adams RH (2015). Regulation of tissue morphogenesis by endothelial cell-derived signals. Trends Cell Biol 25:148-57.

2014

Xu C, Hasan SS, Schmidt I, Rocha SF, Pitulescu ME, Bussmann J, Meyen D, Raz E, Adams RH, Siekmann AF. (2014). Arteries are formed by vein-derived endothelial tip cells. Nat Commun. Dec 15;5:5758.

Pitulescu ME, Adams RH. (2014). Regulation of signaling interactions and receptor endocytosis in growing blood vessels. Cell Adh Migr.8(4):366-77.

Murphy PA, Kim TN, Huang L, Nielsen CM, Lawton MT, Adams RH, Schaffer CB, Wang RA. (2014).  Constitutively active Notch4 receptor elicits brain arteriovenous malformations through enlargement of capillary-like vessels. Proc Natl Acad Sci USA. Dec 16;111(50):18007-12.

Kusumbe AP, Adams RH. (2014). Osteoclast progenitors promote bone vascularization and osteogenesis. Nat Med. Nov;20(11):1238-40.

Ottone C, Krusche B, Whitby A, Clements M, Quadrato G, Pitulescu ME, Adams RH, Parrinello S. (2014). Direct cell-cell contact with the vascular niche maintains quiescent neural stem cells. Nat Cell Biol. Nov;16(11):1045-56.

Weiss AC, Airik R, Bohnenpoll T, Greulich F, Foik A, Trowe MO, Rudat C, Costantini F, Adams RH, Kispert A. (2014). Nephric duct insertion requires EphA4/EphA7 signaling from the pericloacal mesenchyme. Development. Sep;141(17):3420-30.

Rocha SF, Schiller M, Jing D, Li H, Butz S, Vestweber D, Biljes D, Drexler HC, Nieminen-Kelhä M, Vajkoczy P, Adams S, Benedito R, Adams RH. (2014). Esm1 modulates endothelial tip cell behavior and vascular permeability by enhancing VEGF bioavailability. Circ Res. Aug 29;115(6):581-90.

R. Hinkel, T. Trenkwalder, B. Petersen, W. Husada, F. Gesenhues, S. Lee, E. Hannappel, I. Bock-Marquette, D. Theisen, L. Leitner, P. Boekstegers, C. Cierniewski, O.J. Müller, F. le Noble, R.H. Adams, C. Weinl, A. Nordheim, B. Reichart, C. Weber, E. Olson, G. Posern, E. Deindl, H. Niemann,  C. Kupatt  (2014), MRTF-A controls vessel growth and maturation by increasing the expression of CCN1 and CCN2. Nat Commun.,Jun 9;5:3970.

S. Hultin, Y. Zheng, M. Mojallal, S. Vertuani, C. Gentili, M. Balland, R. Milloud, H.G. Belting, M. Affolter, C.S. Helker, R.H. Adams, W.  Herzog, P. Uhlen, A. Majumdar, L. Holmgren (2014). AmotL2 links VE-cadherin to contractile actin fibres necessary for aortic lumen expansion. Nat Commun. May 7;5:3743.

E. Azzoni, V. Conti, L. Campana, A. Dellavalle, R.H. Adams, G. Cossu, S. Brunelli (2014). Hemogenic endothelium generates mesoangioblasts that contribute to several mesodermal lineages in vivo. Development. May;141(9):1821-34.

H. Noels, B. Zhou, P.V. Tilstam, W. Theelen, X. Li, L. Pawig, C. Schmitz, S. Akhtar, S. Simsekyilmaz, E. Shagdarsuren, A. Schober, R.H. Adams, J. Bernhagen, E.A. Liehn, Y. Döring, C. Weber (2014). Deficiency of endothelial CXCR4 reduces reendothelialization and enhances neointimal hyperplasia after vascular injury in atherosclerosis-prone mice. Arterioscler Thromb Vasc Biol. Jun;34(6):1209-20.

C. Korn, B. Scholz, J. Hu, K. Srivastava, J. Wojtarowicz, T. Arnsperger, R.H. Adams, M. Boutros, H.G. Augustin, I. Augustin (2014). Endothelial cell-derived non-canonical Wnt ligands control vascular pruning in angiogenesis. Development. Apr;141(8):1757-66.

S.K. Ramasamy, A.P. Kusumbe, L. Wang, R.H. Adams (2014). Endothelial Notch activity promotes angiogenesis and osteogenesis in bone. Nature. Mar 20;507(7492):376-80.

A.P. Kusumbe, S.K. Ramasamy, R.H. Adams (2014). Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone. Nature Mar 20;507(7492):323-8.

J. Hu, R. Popp, T. Frömel, M. Ehling,  K. Awwad, R.H. Adams, H.P. Hammes, I. Fleming (2014). Müller glia cells regulate Notch signaling and retinal angiogenesis via the generation of 19,20-dihydroxydocosapentaenoic acid. J Exp Med. Feb;211(2):281-95.

C. Kim, H. Yang, Y. Fukushima, P.E. Saw, J. Lee, J.S. Park, I. Park, J. Jung, H. Kataoka, D. Lee, W.D. Heo, I. Kim, S. Jon, R.H. Adams, S. Nishikawa, A. Uemura, G.Y. Koh (2014). Vascular RhoJ is an effective and selective target for tumor angiogenesis and vascular disruption. Cancer Cell. Jan; 25(1):102-17.

G. D'Amico, E.A. Korhonen, A. Anisimov, G. Zarkada, T. Holopainen, R. Hägerling, F. Kiefer, L. Eklund, R. Sormunen, H. Elamaa, R.A. Brekken, R.H. Adams, G.Y. Koh, P. Saharinen, K. Alitalo (2014). Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy. J Clin Invest. Feb;124(2):824-34.

M.L. Arcangeli, F. Bardin, V. Frontera, G. Bidaut, E. Obrados, R.H. Adams, C. Chabannon, M. Aurrand-Lions (2014). Function of Jam-B/Jam-C interaction in homing and mobilization of human and mouse hematopoietic stem and progenitor cells. Stem Cells. Apr;32(4):1043-54.

K.L. Tessneer, S. Pasula, X. Cai, Y. Dong, J. McManus, X. Liu, L. Yu, S. Hahn, B. Chang, Y. Chen, C. Griffin, L. Xia, R.H. Adams, H. Chen (2014). Genetic reduction of vascular endothelial growth factor receptor 2 rescues aberrant angiogenesis caused by epsin deficiency. Arterioscler Thromb Vasc Biol. Feb;34(2):331-7.

W.K. You, F. Yotsumoto, K. Sakimura, R.H. Adams, W.B. Stallcup (2014), NG2 proteoglycan promotes tumor vascularization via integrin-dependent effects on pericyte function. Angiogenesis Jan (1),61-76.

2013

A. Nakayama, M. Nakayama, C.J. Turner, S. Höing, J.J. Lepore, R.H. Adams (2013). Ephrin-B2 controls PDGFRβ internalization and signaling. Genes Dev. Dec;27(23):2576-89.

N.C. Henderson, T.D. Arnold, Y. Katamura, M.M. Giacomini, J.D. Rodriguez, J.H. McCarty, A. Pellicoro, E. Raschperger, C. Betsholtz, P.G. Ruminski, D.W. Griggs, M.J. Prinsen, J.J. Maher, J.P. Iredale, A. Lacy-Hulbert, R.H. Adams, D. Sheppard (2013). Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs. Nat Med. Dec;(12):1617-24.

M. Hupe,  M.X. Li, K. Gertow Gillner, R.H. Adams, J.M. Stenman (2013). Evaluation of TRAP-sequencing technology with a versatile conditional mouse model. Nucleic Acids Res. Jan;42(2):e14.

M. Corada, F. Orsenigo, M.F. Morini, M.E. Pitulescu, G. Bhat, D. Nyqvist, F. Breviario, V. Conti, A. Briot, M.L. Iruela-Arispe, R.H. Adams, E. Dejana (2013). Sox17 is indispensable for acquisition and maintenance of arterial identity. Nat Commun. 4:2609.

M. Ehling, S. Adams, R. Benedito, R.H. Adams (2013), Notch controls retinal blood vessel maturation and quiescence. Development. Jul;140(14):3051-61.

K.K. Sivaraj, M. Takefuji, I. Schmidt, R.H. Adams, S. Offermanns, N. Wettschureck (2013), G13 controls angiogenesis through regulation of VEGFR-2 expression. Dev Cell. May 28;25(4):427-34.

C. Weinl, H. Riehle, D. Park, C. Stritt, S. Beck, G. Huber, H. Wolburg, E.N. Olson, M.W. Seeliger, R.H.  Adams, A. Nordheim (2013), Endothelial SRF/MRTF ablation causes vascular disease phenotypes in murine retinae. J Clin Invest. May 1;123(5):2193-206.

T. Koyama, L. Ochoa-Callejero, T. Sakurai, A. Kamiyoshi, Y. Ichikawa-Shindo, N. Iinuma, T. Arai, T. Yoshizawa, Y. Iesato, Y. Lei, R. Uetake, A. Okimura, A.Yamauchi, M. Tanaka, K.Igarashi, Y. Toriyama, H. Kawate, R.H. Adams, H. Kawakami, N. Mochizuki, A. Martínez, T. Shindo (2013), Vascular endothelial adrenomedullin-RAMP2 system is essential for vascular integrity and organ homeostasis. Circulation. 2013 Feb 19;127(7):842-53.

S.S.D. Peddibhotala, B.F. Brinkmann,  D. Kummer, H. Tuncay, M. Nakayama, R.H.  Adams, V. Gerke and K. Ebnet (2013), Tetraspanin CD9 links junctional adhesion molecule-A to αvβ3 integrin to mediate basic fibroblast growth factor-specific angiogenic signaling. Mol Biol Cell, Apr;24(7):933-44.

M. Nakayama, A. Nakayama, M. van Lessen,  H. Yamamoto, S. Hoffmann, H.C.A.  Drexler, N. Itoh,  T. Hirose, G. Breier, D. Vestweber, J.A. Cooper, S. Ohno, K.  Kaibuchi and R.H. Adams (2013),  Spatial regulation of VEGF receptor endocytosis in angiogenesis. Nat Cell Biol, Published online: 27 January 2013, doi:10.1038/ncb2679

R. Hägerling, C. Pollmann, C. Andreas, C. Schmidt, H. Nurmi, R.H. Adams, K.  Alitalo, V. Andresen, S. Schulte-Merker and F. Kiefer (2013), A novel multistep mechanism for initial lymphangiogenesis in mouse embryos based on ultramicroscopy. EMBO J, Published online: 8 January 2013, doi: 10.1038/emboj.2012.340

H. Yang, S. Lee, S. Lee, K. Kim, Y. Yang, J.H. Kim, R.H. Adams, J.M. Wells, S.J. Morrison, G.Y. Koh and I. Kim (2013), Sox17 promotes tumor angiogenesis and destabilizes tumor vessels in mice. J Clin Invest. 123:418-31.

L. Wang,  R. Benedito,  M.G. Bixel, D. Zeuschner, M. Stehling, L. Sävendahl,  J.J. Haigh, H. Snippert,  H. Clevers,  G. Breier, F. Kiefer and R.H. Adams (2013), Identification of a clonally expanding haematopoietic compartment in bone marrow. EMBO J. 32:219-30.

2012

M.L. Arcangeli, V. Frontera, F. Bardin,  J. Thomassin,  B. Chetaille,  S. Adams, R.H. Adams,  and M. Aurrand-Lions (2012), The junctional adhesion molecule-B regulates JAM-C-dependent melanoma cell metastasis. FEBS Lett. 586:4046-51.

L. Wyss,  J. Schäfer,  S. Liebner,  M. Mittelbronn, U. Deutsch,  G. Enzmann, R.H.  Adams,  M. Aurrand-Lions, K.H. Plate, B.A. Imhof, and B. Engelhardt (2012), Junctional adhesion molecule (JAM)-C deficient  C57BL/6 mice develop a severe ydrocephalus. PLoS One 7(9):e45619.

K. Yoshioka, K. Yoshida,  H. Cui, T. Wakayama,  N. Takuwa, Y. Okamoto, W. Du, X. Qi, K. Asanuma,  K. Sugihara, S. Aki, H. Miyazawa, K. Biswas, C. Nagakura,  M. Ueno, S. Iseki, R.J. Schwartz, H. Okamoto, T. Sasaki, O. Matsui, M. Asano, R.H.  Adams, N. Takakura and Y. Takuwa (2012), Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function. Nat Med. 18:1560-9.

K. Gaengel, C. Niaudet,  K. Hagikura, B.L. Liemsen, L. Muhl, J.J. Hofmann, L. Ebarasi, S. Nyström, S. Rymo, L.L. Chen, M.F. Pang, Y. Jin, E. Raschperger, P. Roswall, D. Schulte, R. Benedito, J. Larsson, M. Hellström, J. Fuxe, P. Uhlén, R. Adams, L. Jakobsson, A. Majumdar, D. Vestweber, A. Uv and C. Betsholtz (2012), The sphingosine-1-phosphate receptor S1PR1 restricts sprouting angiogenesis by regulating the interplay between VE-cadherin and VEGFR2. Dev Cell. 23:587-99.

J.L. Lucitti, J.K. Mackey, J.C. Morrison, J.J. Haigh, R.H. Adams and J.E. Faber (2012), Formation of the collateral circulation is regulated by vascular endothelial growth factor-a and a disintegrin and metalloprotease family members 10 and 17. Circ Res.111:1539-50.

N. Izumi, C. Helker, M. Ehling, A. Behrens, W. Herzog and R.H. Adams (2012), Fbxw7 controls angiogenesis by regulating endothelial Notch activity. PLoS One 7(7):e41116.

R. Benedito, S.F. Rocha, M. Woeste, M. Zamykal, F. Radtke, O. Casanovas, A. Duarte, B. Pytowski and R.H. Adams (2012), Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling. Nature 484:110-4.

A. Sabine, Y. Agalarov, H. Maby-El Hajjami, M. Jaquet, R. Hägerling, C. Pollmann,  D. Bebber, A. Pfenniger, N. Miura, O. Dormond, J.M. Calmes, R.H. Adams, T. Mäkinen, F. Kiefer, B.R. Kwak and T.V. Petrova (2012), Mechanotransduction, PROX1, and FOXC2 cooperate to control connexin37 and calcineurin during lymphatic-valve formation. Dev Cell. 22:430-45.

F. Cesca, A. Yabe B. Spencer-Dene, J. Scholz-Starke, L. Medrihan, C.H. Maden,  H. Gerhardt, I.R. Orriss, P. Baldelli, M. Al-Qatari, M. Koltzenburg, R.H. Adams, F. Benfenati, G. Schiavo (2012), Kidins220/ARMS mediates the integration of the neurotrophin and VEGF pathways in the vascular and nervous systems. Cell Death Differ. 19:194-208.

2011

M.L. Arcangeli, V. Frontera, F. Bardin, E. Obrados, S. Adams, C. Chabannon, C.  Schiff, S.J. Mancini, R.H. Adams and M. Aurrand-Lions (2011), JAM-B regulates maintenance of hematopoietic stem cells in the bone marrow. Blood 118:4609-19.

G. Boulday, N. Rudini, L. Maddaluno, A. Blécon, M. Arnould, A. Gaudric, F. Chapon, R.H. Adams, E. Dejana and E. Tournier-Lasserve (2011), Developmental timing of CCM2 loss influences cerebral cavernous malformations in mice. J Exp Med. 208:1835-47.

B. Bréart, W.D. Ramos-Perez, A. Mendoza, A.K. Salous, M. Gobert, Y. Huang,  R.H. Adams, J.J. Lafaille, D. Escalante-Alcalde, A.J. Morris and S.R. Schwab (2011), Lipid phosphate phosphatase 3 enables efficient thymic egress. J Exp Med. 2011; 208:1267-78.

2010

R. H. Adams and A. Eichmann (2010), Axon guidance molecules in vascular patterning. Cold Spring Harb Perspect Biol. 2(5): a001875.

M.L. Bochenek, S. Dickinson, J.W. Astin, R.H. Adams and C.D. Nobes (2010), Ephrin-B2 regulates endothelial cell morphology and motility independently of Eph-receptor binding. J Cell Sci 123(Pt 8):1235-46.

M. Corada, D. Nyqvist, F. Orsenigo, A. Caprini, C. Giampietro, M.M. Taketo, M.I. Iruela Arispe, R.H. Adams and E. Dejana (2010), The Wnt/ß-catenin pathway modulates vascular remodeling and specification by upregulating Dll4/Notch signaling. Dev.Cell 15:938-49.

M. Mahmoud, K.R. Allinson, Z. Zhai, R. Oakenfull, P. Ghandi, R.H. Adams, M. Fruttiger and H.M. Arthur (2010), Pathogenesis of arteriovenous malformations in the absence of endoglin. Circ Res. 106(8):1425-33.

M.E. Pitulescu and R.H. Adams. (2010), Eph/ephrin molecules-a hub for signaling and endocytosis. Genes Dev 24:2480-92.

S. Sawamiphak, S. Seidel, C.L. Essmann, G.A. Wilkinson, M.E.  Pitulescu, T. Acker and A. Acker-Palmer (2010), Ephrin-B2 regulates VEGFR2 function in developmental and tumor angiogenesis. Nature 465(7297):487-91.

Y. Wang, M. Nakayama, M.E. Pitulescu, T.S. Schmidt, M.L. Bochenek, A. Sakakibara, S. Adams, D. Davy, U. Deutsch, U. Lüthi,  A. Barberis, L.E. Benjamin, T. Mäkinen, C.D. Nobes and R.H. Adams (2010), Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis. Nature 465(7297):483-486.

L. Luna-Zurita, B. Prados, J. Grego-Bessa, G. Luxán, G. del Monte, A. Benguriá, R.H. Adams, J.M. Pérez-Pomares and J.L. de la Pompa (2010), Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation. J Clin Invest 120:3493-507.

S. Parrinello, I. Napoli, S. Ribeiro, P.W. Digby, M. Fedorova, D.B. Parkinson, R.D. Doddrell, M. Nakayama, R.H. Adams and A.C. Lloyd (2010), EphB signaling directs peripheral nerve regeneration through Sox2-dependent Schwann cell sorting. Cell 143:145-55

H.M. Eilken and R.H. Adams (2010), Dynamics of endothelial cell behavior in sprouting angiogenesis. Curr Opin Cell Biol. 22:617-25.

L.E. Reynolds, A.R. Watson, M. Baker, T.A. Jones, G. D'Amico, S.D. Robinson, C. Joffre, S. Garrido-Urbani, J.C. Rodriguez-Manzaneque, E. Martino-Echarri, M. Aurrand-Lions, D. Sheer, F. Dagna-Bricarelli, D. Nizetic, C.J. McCabe, A.S. Turnell,  S. Kermorgant, B.A. Imhof, R. Adams, E.M. Fisher, V.L. Tybulewicz, I.R. Hart and K.M. Hodivala-Dilke (2010), Tumour angiogenesis is reduced in the Tc1 mouse model of Down's syndrome. Nature 465(7299):813-7.

M.E. Pitulescu, I. Schmidt, R. Benedito and R.H. Adams (2010), Inducible gene targeting in the neonatal vasculature and analysis of retinal angiogenesis in mice. Nat Protoc. 5:1518-34.

H.M. Eilken and R.H. Adams (2010), Turning on the angiogenic microswitch. Nat Med. 16:853-4.

K.E. Foster, J. Gordon, K. Cardenas, H. Veiga-Fernandes, T. Makinen, E. Grigorieva,   D.G. Wilkinson, C.C. Blackburn E. Richie, N.R. Manley, R.H. Adams, D. Kioussis and M.C. Coles (2010), EphB-ephrin-B2 interactions are required for thymus migration during organogenesis. Proc Natl Acad Sci USA 107:13414-9.

 
loading content