Publikationen
Ausgewählte Publikationen
2025
Holtermann L, Rivera-Galdos R, Nottebaum AF, Wessel F, Ipe U, Vestweber D. Distinct VE-cadherin serine and tyrosine phosphorylation sites and their role for inflammation-induced vascular permeability in vivo. Cell Mol Life Sci., 2025 Jun 5;82(1):223. doi: 10.1007/s00018-025-05753-2.
Mishra S, Ipe U, Nottebaum AF, Peters KG, Vestweber D. Inhibition of VE-PTP rejuvenates Schlemm's canal in aged mice and acts via Tie2. PLoS One, 2025 May 16;20(5):e0323615. doi: 10.1371/journal.pone.0323615.
Aldirawi M, Ghanbari P, Mietkowska M, März S, Odenthal-Schnittler M, Franz J, Wegner J, Currie S, Kipcke JP, Taha M, Giglmaier M, Blanque A, Schillers H, Raz E, Vestweber D, Rottner K, Schnittler H. A specific role for endothelial EPLIN-isoform-regulated actin dynamics in neutrophil transmigration. Sci Rep., 2025 May 5;15(1):15698. doi: 10.1038/s41598-025-98192-9.
Ghanbarpour Houshangi M, Shirakura K, Vestweber D. Tie-2 regulates endothelial morphological responses to shear stress by FOXO1-triggered autophagy. PLoS One, 2025 May 5;20(5):e0322869. doi: 10.1371/journal.pone.0322869.
Schoofs H, Daubel N, Schnabellehner S, Grönloh MLB, Palacios Martínez S, Halme A, Marks AM, Jeansson M, Barcos S, Brakebusch C, Benedito R, Engelhardt B, Vestweber D, Gaengel K, Linsenmeier F, Schürmann S, Saharinen P, van Buul JD, Friedrich O, Smith RS, Majda M, Mäkinen T. Dynamic cytoskeletal regulation of cell shape supports resilience of lymphatic endothelium. Nature, 2025 May;641(8062):465-475. doi: 10.1038/s41586-025-08724-6.
2024
Stegmeyer RI, Holstein K, Spring K, Timmerman I, Xia M, Stasch M, Möller T, Nottebaum AF, Vestweber D. Csk controls leukocyte extravasation via local regulation of Src family kinases and cortactin signaling. Front Immunol., 2024 Oct 28;15:1480152. doi: 10.3389/fimmu.2024.1480152.
Stegmeyer RI, Stasch M, Olesker D, Taylor JM, Mitchell TJ, Hosny NA, Kirschnick N, Spickermann G, Vestweber D, Volkery S. Intravital Microscopy With an Airy Beam Light Sheet Microscope Improves Temporal Resolution and Reduces Surgical Trauma. Microsc Microanal., 2024 Nov 4;30(5):925-943. doi: 10.1093/mam/ozae099.
Vestweber D, Claesson-Welsh L, McDonald DM, Williams T, Schwartz MA, Scallan J, Gavins FNE, van Buul J, Gamble J, Vadas M, Annex BH, Messe SR, Perretti M, André H, Ferrara N, Hla T, Nourshargh S, Simons M. Report from the 2023 workshop on endothelial permeability, edema and inflammation. Nat Cardiovasc Res., 2023 Dec;2(12):1120-1124. doi: 10.1038/s44161-023-00385-w.
Wilkens M, Holtermann L, Stahl AK, Stegmeyer RI, Nottebaum AF, Vestweber D. Ubiquitination of VE-cadherin regulates inflammation-induced vascular permeability in vivo. EMBO Rep., 2024 Sep;25(9):4013-4032. doi: 10.1038/s44319-024-00221-7.
Xia M, Stegmeyer RI, Shirakura K, Butz S, Thiriot A, von Andrian UH, Vestweber D. Conditions that promote transcellular neutrophil migration in vivo. Sci Rep., 2024 Jun 24;14(1):14471. doi: 10.1038/s41598-024-65173-3.
Burg N, Malpass R, Alex L, Tran M, Englebrecht E, Kuo A, Pannelini T, Minett M, Athukorala K, Worgall T, Faust HJ, Goodman S, Mehta B, Vestweber D, Wei K, Blobel C, Hla T, Salmon JE. Endothelial cell sphingosine 1-phosphate receptor 1 restrains VE-cadherin cleavage and attenuates experimental inflammatory arthritis. JCI Insight., 2024 Jun 10;9(11):e171467. doi: 10.1172/jci.insight.171467.
Baluk P, Shirakura K, Vestweber D, McDonald DM. Heterogeneity of endothelial VE-PTP downstream polarization, Tie2 activation, junctional claudin-5, and permeability in the aorta and vena cava. Cell Tissue Res., 2024 Jan;395(1):81-103. doi: 10.1007/s00441-023-03844-9.
2023
Pruenster M, Immler R, Roth J, Kuchler T, Bromberger T, Napoli M, Nussbaumer K, Rohwedder I, Wackerbarth LM, Piantoni C, Hennis K, Fink D, Kallabis S, Schroll T, Masgrau-Alsina S, Budke A, Liu W, Vestweber D, Wahl-Schott C, Roth J, Meissner F, Moser M, Vogl T, Hornung V, Broz P, Sperandio M. E-selectin-mediated rapid NLRP3 inflammasome activation regulates S100A8/S100A9 release from neutrophils via transient gasdermin D pore formation. Nat Immunol., 2023 Dec;24(12):2021-2031. doi: 10.1038/s41590-023-01656-1.
Mapunda JA, Pareja J, Vladymyrov M, Bouillet E, Hélie P, Pleskač P, Barcos S, Andrae J, Vestweber D, McDonald DM, Betsholtz C, Deutsch U, Proulx ST, Engelhardt B. VE-cadherin in arachnoid and pia mater cells serves as a suitable landmark for in vivo imaging of CNS immune surveillance and inflammation. Nat Commun., 2023 Sep 20;14(1):5837. doi: 10.1038/s41467-023-41580-4.
Noordstra I, Hermoso MD, Schimmel L, Bonfim-Melo A, Currin-Ross D, Duong CN, Kalappurakkal JM, Morris RG, Vestweber D, Mayor S, Gordon E, Roca-Cusachs P, Yap AS. An E-cadherin-actin clutch translates the mechanical force of cortical flow for cell-cell contact to inhibit epithelial cell locomotion. Dev Cell., 2023 Sep 25;58(18):1748-1763.e6. doi: 10.1016/j.devcel.2023.06.011.
Lee E, Lee EA, Kong E, Chon H, Llaiqui-Condori M, Park CH, Park BY, Kang NR, Yoo JS, Lee HS, Kim HS, Park SH, Choi SW, Vestweber D, Lee JH, Kim P, Lee WS, Kim I. An agonistic anti-Tie2 antibody suppresses the normal-to-tumor vascular transition in the glioblastoma invasion zone. Exp Mol Med., 2023 Feb;55(2):470-484. doi: 10.1038/s12276-023-00939-9.
Shirakura K, Baluk P, Nottebaum AF, Ipe U, Peters KG, McDonald DM, Vestweber D. Shear stress control of vascular leaks and atheromas through Tie2 activation by VE-PTP sequestration. EMBO Mol Med., 2023 Apr 11;15(4):e16128. doi: 10.15252/emmm.202216128.
Bauer N, Maisuls I, Pereira da Graça A, Reinhardt D, Erapaneedi R, Kirschnick N, Schäfers M, Grashoff C, Landfester K, Vestweber D, Strassert CA, Kiefer F. Genetically encoded dual fluorophore reporters for graded oxygen-sensing in light microscopy. Biosens Bioelectron., 2023 Feb 1;221:114917. doi: 10.1016/j.bios.2022.114917.
2022
Jin Y, Ding Y, Richards M, Kaakinen M, Giese W, Baumann E, Szymborska A, Rosa A, Nordling S, Schimmel L, Akmeriç EB, Pena A, Nwadozi E, Jamalpour M, Holstein K, Sáinz-Jaspeado M, Bernabeu MO, Welsh M, Gordon E, Franco CA, Vestweber D, Eklund L, Gerhardt H, Claesson-Welsh L. Tyrosine-protein kinase Yes controls endothelial junctional plasticity and barrier integrity by regulating VE-cadherin phosphorylation and endocytosis. Nat Cardiovasc Res., 2022 Dec 7;1(12):1156-1173. doi: 10.1038/s44161-022-00172-z.
Sung DC, Chen M, Dominguez MH, Mahadevan A, Chen X, Yang J, Gao S, Ren AA, Tang AT, Mericko P, Patton R, Lee M, Jannaway M, Nottebaum A, Vestweber D, Scallan JP, Kahn ML. Sinusoidal and lymphatic vessel growth is controlled by reciprocal VEGF-C-CDH5 inhibition. Nat Cardiovasc Res., 2022 Nov 1;1(11):1006-1021. doi: 10.1038/s44161-022-00147-0.
Thomas K, Zondler L, Ludwig N, Kardell M, Lüneburg C, Henke K, Mersmann S, Margraf A, Spieker T, Tekath T, Velic A, Holtmeier R, Hermann J, Jankowski V, Meersch M, Vestweber D, Westphal M, Roth J, Schäfers MA, Kellum JA, Lowell CA, Rossaint J, Zarbock A. Glutamine prevents acute kidney injury by modulating oxidative stress and apoptosis in tubular epithelial cells. JCI Insight, 2022 Nov 8;7(21):e163161. doi: 10.1172/jci.insight.163161.
Mildner K, Breitsprecher L, Currie SM, Stegmeyer RI, Stasch M, Volkery S, Psathaki OE, Vestweber D, Zeuschner D. Landmark-based retrieval of inflamed skin vessels enabled by 3D correlative intravital light and volume electron microscopy. Histochem Cell Biol., 2022 Aug;158(2):127-136. doi: 10.1007/s00418-022-02119-8.
Brabenec L, Müller M, Hellenthal KEM, Karsten OS, Pryvalov H, Otto M, Holthenrich A, Matos ALL, Weiss R, Kintrup S, Hessler M, Dell'Aquila A, Thomas K, Naß J, Margraf A, Nottebaum AF, Rossaint J, Zarbock A, Vestweber D, Gerke V, Wagner NM. Targeting Procalcitonin Protects Vascular Barrier Integrity. Am J Respir Crit Care Med., 2022 Aug 15;206(4):488-500. doi: 10.1164/rccm.202201-0054OC.
Li Z, Ludwig N, Thomas K, Mersmann S, Lehmann M, Vestweber D, Pittet JF, Gomez H, Kellum JA, Rossaint J, Zarbock A. The Pathogenesis of Ischemia-Reperfusion Induced Acute Kidney Injury Depends on Renal Neutrophil Recruitment Whereas Sepsis-Induced AKI Does Not. Front Immunol., 2022 Apr 21;13:843782. doi: 10.3389/fimmu.2022.843782.
Wang S, Wang B, Shi Y, Möller T, Stegmeyer RI, Strilic B, Li T, Yuan Z, Wang C, Wettschureck N, Vestweber D, Offermanns S. Mechanosensation by endothelial PIEZO1 is required for leukocyte diapedesis. Blood, 2022 Jul 21;140(3):171-183. doi: 10.1182/blood.2021014614.
Currie SM, Stegmeyer RI, Mildner K, Breitsprecher L, Zeuschner D, Psathaki OE, Schäfer K, Wilkens M, Volkery S, Nieswandt B, Vestweber D. Confocal Real-Time Analysis of Cutaneous Platelet Recruitment during Immune Complex-Mediated Inflammation. J Invest Dermatol., 2022 Oct;142(10):2724-2732.e3. doi: 10.1016/j.jid.2022.03.011.
2021
Duong CN, Brückner R, Schmitt M, Nottebaum AF, Braun LJ, Meyer Zu Brickwedde M, Ipe U, Vom Bruch H, Schöler HR, Trapani G, Trappmann B, Ebrahimkutty MP, Huveneers S, de Rooij J, Ishiyama N, Ikura M, Vestweber D. Force-induced changes of α-catenin conformation stabilize vascular junctions independently of vinculin. J Cell Sci., 2021 Dec 15;134(24):jcs259012. doi: 10.1242/jcs.259012.
Holtkamp SJ, Ince LM, Barnoud C, Schmitt MT, Sinturel F, Pilorz V, Pick R, Jemelin S, Mühlstädt M, Boehncke WH, Weber J, Laubender D, Philippou-Massier J, Chen CS, Holtermann L, Vestweber D, Sperandio M, Schraml BU, Halin C, Dibner C, Oster H, Renkawitz J, Scheiermann C. Circadian clocks guide dendritic cells into skin lymphatics. Nat Immunol., 2021 Nov;22(11):1375-1381. doi: 10.1038/s41590-021-01040-x.
Ninchoji T, Love DT, Smith RO, Hedlund M, Vestweber D, Sessa WC, Claesson- Welsh L. eNOS-induced vascular barrier disruption in retinopathy by c-Src activation and tyrosine phosphorylation of VE-cadherin. Elife, 2021 Apr 28;10:e64944. doi: 10.7554/eLife.64944.
Arif N, Zinnhardt M, Nyamay'Antu A, Teber D, Brückner R, Schaefer K, Li YT, Trappmann B, Grashoff C, Vestweber D. PECAM-1 supports leukocyte diapedesis by tension-dependent dephosphorylation of VE-cadherin. EMBO J., 2021 May 3;40(9):e106113. doi: 10.15252/embj.2020106113.
Vestweber D. Vascular Endothelial Protein Tyrosine Phosphatase Regulates Endothelial Function. Physiology, 2021 Mar 1;36(2):84-93. doi: 10.1152/physiol.00026.2020.
2020
Li G, Nottebaum AF, Brigell M, Navarro ID, Ipe U, Mishra S, Gomez-Caraballo M, Schmitt H, Soldo B, Pakola S, Withers B, Peters KG, Vestweber D, Stamer WD. A Small Molecule Inhibitor of VE-PTP Activates Tie2 in Schlemm's Canal Increasing Outflow Facility and Reducing Intraocular Pressure. Invest Ophthalmol Vis Sci., 2020 Dec 1;61(14):12. doi: 10.1167/iovs.61.14.12.
Rademakers T, Goedhart M, Hoogenboezem M, García Ponce A, van Rijssel J, Samus M, Schnoor M, Butz S, Huveneers S, Vestweber D, Nolte MA, Voermans C, van Buul JD. Hematopoietic stem and progenitor cells use podosomes to transcellularly cross the bone marrow endothelium. Haematologica, 2020 Dec 1;105(12):2746-2756. doi: 10.3324/haematol.2018.196329.
Frye M, Stritt S, Ortsäter H, Hernandez Vasquez M, Kaakinen M, Vicente A, Wiseman J, Eklund L, Martínez-Torrecuadrada JL, Vestweber D, Mäkinen T. EphrinB2-EphB4 signalling provides Rho-mediated homeostatic control of lymphatic endothelial cell junction integrity. Elife, 2020 Sep 8;9:e57732. doi: 10.7554/eLife.57732.
Rezaei M, Martins Cavaco AC, Stehling M, Nottebaum A, Brockhaus K, Caliandro MF, Schelhaas S, Schmalbein F, Vestweber D, Eble JA. Extracellular Vesicle Transfer from Endothelial Cells Drives VE-Cadherin Expression in Breast Cancer Cells, Thereby Causing Heterotypic Cell Contacts. Cancers., 2020 Aug 1;12(8):2138. doi: 10.3390/cancers12082138.
Brulois K, Rajaraman A, Szade A, Nordling S, Bogoslowski A, Dermadi D, Rahman M, Kiefel H, O'Hara E, Koning JJ, Kawashima H, Zhou B, Vestweber D, Red- Horse K, Mebius RE, Adams RH, Kubes P, Pan J, Butcher EC. A molecular map of murine lymph node blood vascular endothelium at single cell resolution. Nat Commun., 2020 Jul 30;11(1):3798. doi: 10.1038/s41467-020-17291-5.
Margraf A, Germena G, Drexler HCA, Rossaint J, Ludwig N, Prystaj B, Mersmann S, Thomas K, Block H, Gottschlich W, Liu C, Krenn PW, Haller H, Heitplatz B, Meyer Zu Brickwedde M, Moser M, Vestweber D, Zarbock A. The integrin-linked kinase is required for chemokine-triggered high-affinity conformation of the neutrophil β2-integrin LFA-1. Blood, 2020 Nov 5;136(19):2200-2205. doi: 10.1182/blood.2020014614.
Duong CN, Vestweber D. Mechanisms Ensuring Endothelial Junction Integrity Beyond VE-Cadherin. Front Physiol., 2020 May 21;11:519. doi: 10.3389/fphys.2020.00519.
Sheikh BN, Guhathakurta S, Tsang TH, Schwabenland M, Renschler G, Herquel B, Bhardwaj V, Holz H, Stehle T, Bondareva O, Aizarani N, Mossad O, Kretz O, Reichardt W, Chatterjee A, Braun LJ, Thevenon J, Sartelet H, Blank T, Grün D, von Elverfeldt D, Huber TB, Vestweber D, Avilov S, Prinz M, Buescher JM, Akhtar A. Neural metabolic imbalance induced by MOF dysfunction triggers pericyte activation and breakdown of vasculature. Nat Cell Biol., 2020 Jul;22(7):828-841. doi: 10.1038/s41556-020-0526-8.
Braun LJ, Stegmeyer RI, Schäfer K, Volkery S, Currie SM, Kempe B, Nottebaum AF, Vestweber D. Platelets docking to VWF prevent leaks during leukocyte extravasation by stimulating Tie-2. Blood, 2020 Jul 30;136(5):627-639. doi: 10.1182/blood.2019003442.
Smith RO, Ninchoji T, Gordon E, André H, Dejana E, Vestweber D, Kvanta A, Claesson-Welsh L. Vascular permeability in retinopathy is regulated by VEGFR2 Y949 signaling to VE-cadherin. Elife, 2020 Apr 21;9:e54056. doi: 10.7554/eLife.54056.
Bergerhausen L, Grosche J, Meißner J, Hecker C, Caliandro MF, Westerhausen C, Kamenac A, Rezaei M, Mörgelin M, Poschmann G, Vestweber D, Hanschmann EM, Eble JA. Extracellular Redox Regulation of α7β Integrin-Mediated Cell Migration Is Signaled via a Dominant Thiol-Switch. Antioxidants, 2020 Mar 10;9(3):227. doi: 10.3390/antiox9030227.
Owen-Woods C, Joulia R, Barkaway A, Rolas L, Ma B, Nottebaum AF, Arkill KP, Stein M, Girbl T, Golding M, Bates DO, Vestweber D, Voisin MB, Nourshargh S. Local microvascular leakage promotes trafficking of activated neutrophils to remote organs. J Clin Invest., 2020 May 1;130(5):2301-2318. doi: 10.1172/JCI133661.
Samus M, Li YT, Sorokin L, Rottner K, Vestweber D. Actin-Binding Protein Cortactin Promotes Pathogenesis of Experimental Autoimmune Encephalomyelitis by Supporting Leukocyte Infiltration into the Central Nervous System. J Neurosci., 2020 Feb 12;40(7):1389-1404. doi: 10.1523/JNEUROSCI.1266-19.2019.
Duong CN, Nottebaum AF, Butz S, Volkery S, Zeuschner D, Stehling M, Vestweber D. Interference With ESAM (Endothelial Cell-Selective Adhesion Molecule) Plus Vascular Endothelial-Cadherin Causes Immediate Lethality and Lung-Specific Blood Coagulation. Arterioscler Thromb Vasc Biol., 2020 Feb;40(2):378-393. doi: 10.1161/ATVBAHA.119.313545.
2019
Thomson BR, Carota IA, Souma T, Soman S, Vestweber D, Quaggin SE. Targeting the vascular specific PTPRB protects against retinal ganglion cell loss in a pre-clinical model of glaucoma. eLIFE, Oct 17;8 pii:e48474 [Epub ahead of print]
Herich S, Schneider-Hohendorf T, Rohlmann A, Khaleghi Ghadiri M, Schulte-Mecklenbeck A, Zondler L, Janoschka C, Ostkamp P, Richter J, Breuer J, Dimitrov S, Grauer OM, Klotz L, Gross CC, Stummer W, Missler M, Zarbock A, Vestweber D, Wiendl H, Schwab N. CCR5high effector-memory cells perform CNS parenchymal immune surveillance in humans via Granzyme K-mediated transendothelial diapedesis. Brain, 142: 3411-3427.
Drexler HCA, Vockel M, Polaschegg C, Frye M, Peters K, Vestweber D. Vascular endothelial receptor tyrosine phosphatase: Identification of novel substrates related to junctions and a ternary complex with EphB4 and Tie-2. Mol. Cell Proteomics, 2019 Oct;18(10):2058-2077.
Li YT, Goswami D, Pacheco-Blanco M, Artz A, Vestweber D. Blood flow guides sequential support of neutrophil arrest and diapedesis by PILR-b1 and PILR-a. eLIFE, 2019 Aug 6;8. pii: e47642. doi: 10.7554/eLife.47642.
Braun LJ, Zinnhardt M, Vockel M, Drexler HC, Peters K, Vestweber D. VE-PTP inhibition stabilizes endothelial junctions by activating FGD5. EMBO Rep. 2019 Jul; 20(7) e47046
Carota IA, Kenig-Kozlovsky Y, Onay T, Scott R, Thomson BR, Souma T, Bartlett CS, Li Y, Procissi D, Ramirez V, Yamaguchi S, Tarjus A, Tanna CE, Li C, Eremina V, Vestweber D, Oladipupo SS, Breyer MD, Quaggin SE. Targeting VE-PTP phosphatase protects the kidney from diabetic injury. J. Exp. Med. 2019 216(4):936-949.
2018
Hägerling R, Hoppe E, Dierkes C, Stehling M, Makinen T, Butz S, Vestweber D, Kiefer F. Distinct roles of VE-cadherin for development and maintenance of specific lymph vessel beds. EMBO J. 37(22) pii: e98271. doi: 10.15252/embj.201798271. Epub 2018 Oct 8.
Reckzeh K, Kizilkaya H, Helbo AS, Alrich ME, Deslauriers AG, Grover A, Rapin N, Asmar F, Grønbæk K, Porse B, Borregaard N, Vestweber D, Nerlov C, Theilgaard-Mönch K. Human adult HSCs can be discriminated from lineage-committed HPCs by the expression of endomucin. Blood Adv. 2: 1628-1632
Samus M, Seelige R, Schäfer K, Sorokin L, Vestweber D. CD99L2 deficiency inhibits leukocyte entry into the central nervous system and ameliorates neuroinflammation. J. Leukoc. Biol. 104:787-797
Schwartz MA, Vestweber D, Simons M. A unifying concept in vascular health and disease. Science 360: 270-271
Souma T, Thomson B, Heinen S, Carota I, Yamaguchi S, Onay T, Liu P, Ghosh A, Li C, Eremina V, Hong YK, Economides A, Vestweber D, Peters K, Jin J, Quaggin S. Context-dependent functions of Angiopoietin 2 are determined by the endothelial phosphatase VEPTP. Proc. Natl. Acad. Sci. USA 115: 1298-1303
2017
Liu Y, Shen J, Fortmann SD, Wang J, Vestweber D, Campochiaro PA. Reversible Retinal Vessel Closure from VEGF-induced Leukostasis. JCI Insight 2017 Sep 21;2(18). pii: 95530. doi: 10.1172/jci.insight.95530. [Epub ahead of print]
Hägerling R, Drees D, Scherzinger A, Dierkes C, Martin-Almedina S, Butz S, Gordon K, Schäfers M, Hinrichs K, Ostergaard P, Vestweber D, Goerge T, Mansour S, Jiang X, Mortimer PS, Kiefer F. VIPAR, a diagnostic approach for 3D-histopathology applied to lymphatic malformations. JCI Insight 2017 Aug 17;2(16). pii: 93424. doi: 10.1172/jci.insight.93424. [Epub ahead of print]
Conway DE, Coon BG, Budatha M, Arsenovic PT, Orsenigo F, Wessel F, Zhang J, Zhuang Z, Dejana E, Vestweber D, Schwartz MA. VE-cadherin phosphorylation regulates endothelial fluid shear stress responses through the polarity protein LGN. Curr. Biol. 27:2219-2225
Takahashi K, Kim R, Lauhan C, Park Y, Nguyen NG, Vestweber D, Dominguez MG, Valenzuela DM, Murphy AJ, Yancopoulos GD, Gale NW, Takahashi T. Expression of receptor-type protein tyrosine phosphatase in developing and adult renal vasculature. PLoS One 12:e0177192
Döring Y, Noels H, van der Vorst EPC, Neideck C, Egea V, Drechsler M, Mandl M, Pawig L, Jansen Y, Schröder K, Bidzhekov K, Megens RTA, Theelen W, Klinkhammer BM, Boor P, Schurgers L, van Gorp R, Ries C, Kusters PJH, van der Wal A, Hackeng TM, Gäbel G, Brandes RP, Soehnlein O, Lutgens E, Vestweber D, Teupser D, Holdt LM, Rader DJ, Saleheen D, Weber C. Vascular CXCR4 limits atherosclerosis by maintaining arterial integrity: evidence from mouse and human studies. Circulation 136: 388-402
Haghayegh Jahromi N, Tardent H, Enzmann G, Deutsch U, Kawakami N, Bittner S, Vestweber D, Zipp F, Stein JV, Engelhardt B. A novel cervical spinal cord window preparation allows for two-photon imaging of T-cell intercations with the cervical spinal cord microvasculature during experimental autoimmune encephalomyelitis. Front. Immunol. 8:406
Goswami D, März S, Li YT, Artz A, Schäfer K, Seelige R, Pacheco-Blanco M, Jing D, Bixel MG, Araki M, Araki K, Yamamura K, Vestweber D. Endothelial CD99 supports arrest of mouse neutrophils in venules ad binds to neutrophil PILRs. Blood 129: 1811-1822
Bixel MG, Kusumbe AP, Ramasamy SK, Sivaraj KK, Butz S, Vestweber D, Adams RH. Flow dynamics and HSPC Homing in bone marrow microvessels. Cell Rep. 18:1804-1816
Song J, Zhang X, Buscher K, Wang Y, Wang H, Di Russo J, Li L, Lütke-Enking S, Zarbock A, Stadtmann A, Striewski P, Wirth B, Kuzmanov I, Wiendl H, Schulte D, Vestweber D, Sorokin L. Endothelial basement membrane laminin 511 contributes to endothelial junctional tightness and thereby inhbits leukocyte transmigration. Cell Rep. 18:1256-1269
Latasiewicz J, Artz A, Jing D, Blanco MP, Currie SM, Avila MV, Schnoor M, Vestweber D. HS1 deficiency impairs neutrophil recruitment in vivo and activation of the small GTPases Rac1 and Rap1. J. Leukoc. Biol. 101:1133-1142
Li J, Su Y, Xia W, Humphries M, Vestweber D, Cabanas C, Lu C, Springer TA. Conformational equilibria and intrinsic affinities define the landscape for activation of integrin a5b1. EMBO J. 36:629-645
2016
Kurz AR, Pruenster M, Rohwedder I, Ramadass M, Schäfer K, Harrison U, Gouveia G, Nussbaum C, Immler R, Wiessner JR, Margraf A, Lim DS, Walzog B, Dietzel S, Moser M, Klein C, Vestweber D, Haas R, Catz SD, Sperandio M. MST1-dependent vesicle trafficking regulates neutrophil transmigration through the vascular basement membrane.J Clin Invest. 126:4125-4139
García Ponce A, Citalán Madrid AF, Vargas Robles H, Chánez Paredes S, Nava P, Betanzos A, Zarbock A, Rottner K, Vestweber D, Schnoor M. Loss of cortactin causes endothelial barrier dysfunction via disturbed adrenomedullin contractility. Sci. Rep. 2016(6):29003
Su Y, Xia W, Li J, Walz T, Humphries MJ, Vestweber D, Cabañas C, Lu C, Springer TA. Relating conformation to function in integrin α5β1. Proc. Natl. Acad. Sci. U S A 113(27):E3872-81
Barreiro O, Cibrian D, Clemente C, Alvarez D, Moreno V, Valiente Í, Bernad A, Vestweber D, Arroyo AG, Martín P, von Andrian UH, Sánchez Madrid F. Pivotal role for skin transendothelial radio-resistant anti-inflammatory macrophages in tissue repair. Elife 5. pii: e15251. doi: 10.7554/eLife.15251
Artz A, Butz S, Vestweber D. GDF-15 inhibits integrin activation and mouse neutrophil recruitment through the ALK-5/TGF-βRII heterodimer. Blood 28(4):529-41
Li X, Padhan N, Sjöström EO, Roche FP, Testini C, Honkura N, Sáinz-Jaspeado M, Gordon E, Bentley K, Philippides A, Tolmachev V, Dejana E, Stan RV, Vestweber D, Ballmer-Hofer K, Betsholtz C, Pietras K, Jansson L, Claesson-Welsh L. VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread. Nat. Commun. 7:11017
2015
Frye M, Dierkes M, Küppers V, Vockel M, Tomm J, Zeuschner D, Roissant J, Zarbock A, Koh GY, Peters K, Nottebaum AF, Vestweber D. (2015) Interfering with VE-PTP stabilizes endothelial junctions in vivo via Tie-2 in the absence of VE-cadherin. J. Exp. Med. 212:2267-87
Hillgruber C, Pöppelmann B, Weishaupt C, Steingräber AK, Wessel F, Berdel WE, Gessner JE, Ho-Tin-Noé B, Vestweber D*, Goerge T*. (2015) Blocking neutrophil diapedesis prevents hemorrhage during thrombocytopenia. J. Exp. Med. 212:1255-66 *D.V. and T.G. are shared corresponding authors
Vestweber D. (2015) How leukocytes cross the vascular endothelium. Nat. Rev. Immunol. 15: 692-704
Yamamoto H, Ehling M, Kato K, Kenichi Kanai K, van Lessen M, Frye M, Zeuschner D, Nakayama M, Vestweber D, Adams RH. (2015) Integrin β1 controls VE-cadherin localization and blood vessel stability. Nat. Commun. 6:6429 doi: 10.1038/ncomms7429.
Pruenster M, Kurz ARM, Chung K-J, Cao-Ehlker X, Stephanie, Bieber S, Nussbaum CF, Bierschenk S, Eggersmann TK, Rohwedder I, Heinig K, Immler R, Moser M, Koedel U, Gran S, McEver RP, Vestweber D, Verschoor A, Leandersson T, Chavakis T, Roth J, Vogl T, Sperandio M. (2015) Extracellular MRP8/14 is a regulator of b2 integrin dependent neutrophil slow rolling and adhesion in vivo. Nat. Commun. 6:6915 doi: 10.1038/ncomms7915
Anderson H, Patch TC, Reddy PN, Hagedorn EJ, Kim PG, Soltis KA, Chen MJ, Tamplin OJ, Frye M, MacLean GA, Hübner K, Bauer DE, Kanki JP, Vogin G, Huston NC, Nguyen M, Fujiwara Y, Paw BH, Vestweber D, Zon LI, Orkin SH, Daley GQ, Shah DI. (2015) Hematopoetic stem cells develop in the absence of endothelial cadherin 5 expression. Blood 126:2811-20
Vestweber D. (2015) Cadherins in tissue architecture and disease. J. Mol. Med. (Berl). 93:5-11
2014
Shen J, Frye M, Lee BL, Reinardy JL, McClung JM, Ding K, Kojima M, Xia H, Seidel C, Lima e Silva R, Dong A, Hackett SF, Wang J, Howard BW, Vestweber D, Kontos CD, Peters KG, Campochiaro PA. (2014) Targeting VE-PTP activates TIE2 and stabilizes the ocular vasculature. J. Clin. Invest. 124:4564-76
Schneider-Hohendorf T, Rossaint J, Mohan H, Böning D, Breuer J, Kuhlmann T, Gross CC, Flanagan K, Sorokin L, Vestweber D, Zarbock A, Schwab N, Wiendl H. (2014) VLA-4 blockade promotes differential routes into human CNS involving PSGL-1 rolling of T cells and MCAM-adhesion of TH17 cells. J. Exp. Med. 211:1833-46
Rocha SF, Schiller M, Jing D, Li H, Butz S, Vestweber D, Biljes D, Drexler HC, Nieminen-Kelhä M, Vajkoczy P, Adams S, Benedito R, Adams RH. (2014) Esm1 modulates endothelial tip cell behavior and vascular permeability by enhancing VEGF bioavailability. Circ. Res. 115:581-90
Abadier M, Jahromi NH, Cardoso-Alves L, Boscacci R, Vestweber D, Barnum S, Deutsch U, Engelhardt B, Lyck R. (2014) Cell surface levels of endothelial ICAM-1 influence the transcellular or paracellular T-cell diapedesis across the blood-brain barrier. Eur. J. Immunol. 45:1043-1058
Vestweber D, Wessel F, Nottebaum AF. (2014) Similarities and differences in the regulationof leukocyte extravasation and vascular permeability. Semin. Immunopathol. 36:177-92
Dartsch N, Schulte D, Hägerling R, Kiefer F, Vestweber D. Fusing VE-cadherin to a-catenin impairs fetal liver hematopoiesis and lymph, but not blood vessel formation. Mol. Cell. Biol. (2014) in press
Bentley K, Franco CA, Philippides A, Blanco R, Dierkes M, Gebala V, Stanchi F, Jones M, Aspalter IM, Cagna G, Kutschera S, Claesson-Welsh L, Vestweber D, Gerhardt H. (2014) The role of differential VE-cadherin dynamics in cell rearrangement during angiogenesis. Nat. Cell Biol. in press
Wessel F, Winderlich M, Holm M, Frye M, Rivera-Galdos R, Vockel M, Linnepe R, Ipe U, Stadtmann A, Zarbock A, Nottebaum A, Vestweber D. (2014) Leukocyte extravasation and vascular permeability are each controlled in vivo by a different tyrosine residue of VE-cadherin. Nat. Immunol. 15:223-230
Kraus H, Kaiser S, Aumann K, Bönelt P, Salzer U, Vestweber D, Erlacher M, Kunze M, burger M, Pieper K, Sic H, Rolink A, Eibel H, Rizzi, M. (2014) A feeder free differentiation system identifies autonomously proliferating B cell precursors in human bone marrow. J. Immunol. 192:1044-1054
Gorina R, Lyck R, Vestweber D, Engelhardt B. (2014) β2 Integrin-Mediated Crawling on Endothelial ICAM-1 and ICAM-2 Is a Prerequisite for Transcellular Neutrophil Diapedesis across the Inflamed Blood-Brain Barrier. J. Immunol. 192:324-337
2013
Sehnert B, Burkhardt H, Wessels J, Vestweber D, Zwerina J, Nimmerjahn F, Schett G, Dübel S, Voll RE. (2013) An NF-κB inhibitor targeted to activated endothelium demonstrates a critical role of endothelial NF-κB in immune-mediated diseases. PNAS 110:16556-16561
Vockel M, Vestweber D. (2013) How T cells trigger the dissociation of the endothelial receptor phosphatase VE-PTP from VE-cadherin. Blood 122: 2512-2522
Hillgruber C, Steingräber AK, Pöppelmann B, Denis CV, Ware J, Vestweber D, Nieswandt B, Schneider SW, Goerge T. (2013) Blocking Von Willebrand Factor for treatment of cutaneous inflammation. J. Invest. Dermatol. 134:77-86
Rossaint J, Vestweber D, Zarbock A (2013). GDF-15 prevents platelet integrin activation and thrombus formation. J. Thromb. Haemost. 11:335-344
Nakayama M, Nakayama A, Van Lessen M, Yamamoto H, Hoffmann S, Drexler HCA, Itoh N, Hirose T, Breier G, Vestweber D, Cooper JA, Ohno S, Kaibuchi K, Adams RH. (2013) Spatial regulation of VEGF receptor endocytosis in angiogenesis. Nat. Cell Biol. 15:249-60.
Seelige R, Natsch C, März S, Jing D, Frye M, Butz S, Vestweber D (2013). Endothelial specific gene ablation of CD99L2 impairs leukocyte extravasation in vivo. J. Immunol. 190:892-896
Hayashi M, Majumdar A, Li X, Adler J, Sun Z, Vertuani S, Hellberg C, Mellberg S, Koch S, Dimberg A, Young Koh GY, Dejana E, Belting H-G, Affolter M, Thurston G, Holmgren L, Vestweber D, Claesson-Welsh L. (2013) VE-PTP regulates VEGFR2 stalk cell activity in a Tie2-dependent manner to establish endothelial cell polarity and lumen formation. Nat. Commun. 4:1672.
Dejana E, Vestweber D. (2013) The Role of VE-cadherin in Vascular Morphogenesis and Permeability Control. Prog. Mol. Biol. Transl. Sci. 116:119-44
2012
Gaengel K, Niaudet C, Hagikura K, Siemsen BL, Muhl L, Hofmann JJ, Ebarasi L, Nyström S, Rymo S, Chen LL, Pang MF, Jin Y, Raschperger E, Roswall P, Schulte D, Benedito R, Larsson J, Hellström M, Fuxe J, Uhlén P, Adams R, Jakobsson L, Majumdar A, Vestweber D, Uv A, Betsholtz C (2012). The sphingosine-1-phosphate receptor S1PR1 restricts sprouting angiogenesis by regulating the interplay between VE-cadherin and VEGF-R2. Dev. Cell, 23:587-99
Vestweber D. (2012) Novel insights into leukocyte extravasation.Curr. Opin. Hematol. 19: 212-217
Vestweber D. (2012) Relevance of endothelial junctions in leukocyte extravasation and vascular permeability. Ann. N. Y. Acad. Sci. 1257:184-92
A. Zarbock, T Kempf , K.C. Wollert and Vestweber D. (2012) Leukocyte integrin activation and deactivation: novel mechanisms of balancing inflammation. J. Mol. Med. (Berl). 90:353-359
2011
A. Broermann, M. Winderlich, H. Block, M. Frye, J. Rossaint, A. Zarbock, G. Cagna, R. Linnepe, D. Schulte, A.F. Nottebaum and Vestweber D. (2011) Dissociation of VE-PTP from VE-cadherin is required for leukocyte extravasation and for VEGF-induced vascular permeability in vivo. J. Exp. Med. 208:2393-2401
D. Schulte, V. Küppers, N. Dartsch, A. Broermann, H. Li, A. Zarbock, O. Kamenyeva, F. Kiefer, A. Khandoga, S. Massberg and Vestweber D. (2011) Stabilizing the VE-cadherin-catenin complex blocks leukocyte extravasation and vascular permeability. EMBO J. 30:4157-7410
M. Schnoor, F.P.L. Lai, A. Zarbock, R. Kläver, C. Polaschegg, D. Schulte, H.A. Weich, J.M. Oelkers, K. Rottner and Vestweber, D. (2011) Cortactin deficiency is associated with reduced neutrophil recruitment but increased vascular permeability in vivo. J. Exp. Med. 208:1721-1735
T. Kempf, A. Zarbock, C. Widera, S. Butz, A. Stadtmann, J. Rossaint, M. Bolomini-Vittori, M. Korf-Klingebiel, L.C. Napp, B. Hansen, A. Kanwischer, U. Bavendiek, G. Beutel, M. Hapke, M.G. Sauer, C. Laudanna, N. Hogg, D. Vestweber* and K.C. Wollert* (2011) GDF15, an inhibitor of leukocyte integrin activation required for survival after myocardial infarction. Nat. Med. 17:581-588
*D.V. and K.C.W. are shared corresponding authors
2010
M.G. Bixel, H. Li, B. Petri, A.G. Khandoga, A. Khandoga, A. Zarbock, K. Wolburg-Buchholz, H. Wolburg, L. Sorokin, D. Zeuschner, S. Maerz, S. Butz, F. Krombach and D. Vestweber (2010) CD99 and CD99L2 act at the same site as, but independently of, PECAM-1 during leukocyte diapedesis. Blood 116:1172-1184
B. Petri, A. Broermann, H. Li, A.G. Khandoga, A. Zarbock, F. Krombach, T. Goerge, S.W. Schneider, C. Jones, B. Nieswandt, M.K. Wild and D. Vestweber (2010) Von Willebrand factor promotes leukocyte extravasation. Blood 116:4712-4719
2009
M. Winderlich, L. Keller, G. Cagna, A. Broermann, O. Kamenyeva, F. Kiefer, U. Deutsch, A. Nottebaum and D. Vestweber (2009) VE-PTP controls blood vessel development by balancing Tie-2 activity. J. Cell Biol. 185:657-671
C. Wu, F. Ivars, P. Anderson, R. Hallmann, D. Vestweber, P. Nilsson, H. Robenek, K. Tryggvason, J. Song, E. Korpos, K. Loser, S. Beissert, E. Georges-Labouesse and L. Sorokin (2009) Endothelial Basement Membrane Laminin α5 Selectively Inhibits T Lymphocyte Extravasation Into the Brain. Nat. Med. 15:519-527
A. Tanne, B. Ma, F. Boudou, L. Tailleux, H. Botella, E. Badell, F. Levillain, M.E. Taylor, K. Drickamer, J. Nigou, K.M. Dobos, G. Puzo, D. Vestweber, M.K. Wild, M. Marcinko, P. Sobieszczuk, L. Stewart, D. Lebus, B. Gicquel and O.A. Neyrolles (2009) murine DC-SIGN homologue contributes to early host defense against Mycobacterium tuberculosis. J. Exp. Med. 206:2205-2220
T. Yokota, K. Oritani, S. Butz, K. Kokame, P.W. Kincade, T. Miyata, D. Vestweber and Y. Kanakura (2009) The endothelial antigen ESAM marks primitive hematopoietic progenitors throughout life in mice.Blood 113: 2914-2923
A.G. Ooi, H. Karsunky, R. Majeti, S. Butz, D. Vestweber, T. Ishida, T. Quertermous, I.L. Weissman and E.C. Forsberg (2009) The Adhesion Molecule ESAM1 is A Novel Hematopoietic Stem Cell Marker. Stem Cells 27:653-661
2008
A.F. Nottebaum, G. Cagna, M. Winderlich, A.C. Gamp, R. Linnepe, C. Polaschegg, K. Filippova, R. Lyck, B. Engelhardt, O. Kamenyeva, M.G. Bixel, S. Butz and D. Vestweber (2008) VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF. J. Exp. Med. 205: 2929-2945
D. Frommhold, A. Ludwig, M.G. Bixel, A. Zarbock, I. Babushkina, M. Weissinger, S. Cauwenberghs, L.G. Ellies, J.D. Marth, A.G. Beck-Sickinger, M. Sixt, B. Lange-Sperandio, A. Zernecke, E. Brandt, C. Weber, D. Vestweber, K. Ley and M. Sperandio (2008) Sialyltransferase ST3Gal-IV controls CXCR2-mediated firm leukocyte arrest during inflammation. J. Exp. Med. 205:1435-1446
P. Saharinen, L. Eklund, J. Miettinen, R. Wirkkala, A. Anisimov, M. Winderlich, A. Nottebaum, D. Vestweber, U. Deutsch, G.Y. Koh, B.R. Olsen and K. Alitalo (2008) Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts. Nat Cell Biol. 10:527-537
P.Turowski, R. Martinelli, R. Crawford, D. Wateridge, A.-P. Papagiorgiou, M.G. Lampugnani, A.C. Gamp, D. Vestweber, P. Adamson, E. Dejana and J. Greenwood (2008) Phosphorylation of Vascular Endothelial Cadherin Controls Lymphocyte Emigration. J. Cell Sci. 121: 29-37
2007
M.G. Bixel, B. Petri, A.G. Khandoga, A. Khandoga, K. Wolburg-Buchholz, H. Wolburg, S. Marz, F. Krombach and D. Vestweber (2007) A CD99-related antigen on endothelial cells mediates neutrophil, but not lymphocyte extravasation. Blood 109: 5327-5336
A. Hidalgo, A.J. Peired, M. Wild, D. Vestweber and P.S. Frenette (2007) Complete identification of E-selectin ligand activity on neutrophils reveals a dynamic interplay and distinct functions of PSGL-1, ESL-1 and CD44. Immunity 26: 477-489
P. Baluk, J. Fuxe, H. Hashizume, T. Romano, E. Lashnits, S. Butz, D. Vestweber, M. Corada, C. Molendini, E. Dejana and D.M. McDonald (2007) Functionally specialized junctions between endothelial cells of lymphatic vessels. J. Exp. Med. 204: 2349-2362
M.G. Bixel, B. Petri, A.G. Khandoga, A. Khandoga, K. Wolburg-Buchholz, H. Wolburg, S. Marz, F. Krombach and D. Vestweber (2007) A CD99-related antigen on endothelial cells mediates neutrophil, but not lymphocyte extravasation. Blood 109: 5327-5336
2006
F. Wegmann, B. Petri, A.G. Khandoga, C. Moser, A. Khandoga, S. Volkery, H. Li, I. Nasdala, O. Brandau, R. Fässler, S. Butz, F. Krombach and D. Vestweber (2006) ESAM supports neutrophil extravasation, activation of Rho and VEGF-induced vascular permeability. J. Exp. Med. 203:1671-1677
S. Baumer, L. Keller, A. Holtmann, R. Funke, B. August, A. Gamp, H. Wolburg, K. Wolburg-Buchholz, U. Deutsch and D. Vestweber (2006) Vascular endothelial cell specific phospho-tyrosine phosphatase (VE-PTP) activity is required for blood vessel development. Blood 107:4754-4762
2005
U. Baumeister, R. Funke, K. Ebnet, H. Vorschmitt, S. Koch and D. Vestweber (2005) Association of Csk to VE-cadherin and inhibition of cell proliferation. EMBO J. 24:1686-1695
A. Matsubara, A. Iwama, Y. Yamada, S. Yamazaki, C. Furuta, R. Hirasawa, Y. Morita, M. Osawa, T. Motohashi, K. Eto, H. Ema, T. Kitamura, D. Vestweber and H. Nakauchi (2005) Expression of Endomucin, a CD34-like sialomucin, marks definitive hematopoietic stem cells from their development through life. J. Exp. Med. 202:1483-1492
A.A. Dorner, F. Wegmann, S. Butz, K. Wolburg-Buchholz, H. Wolburg, A. Mack, I. Nasdala, B. August, J. Westermann, F.G. Rathjen and D. Vestweber (2005) Coxsackievirus-Adenovirus-Receptor (CAR) is essential for early embryonic cardiac development. J. Cell Sci. 118:3509-3521
2004
G. Bixel, S. Kloep, S. Butz, B. Petri, B. Engelhardt and D. Vestweber (2004) Mouse CD99 participates in T cell recruitment into inflamed skin. Blood 104:3205-3213
2003
P. Vajkoczy, S. Blum, M. Lamparter, R. Mailhammer, R. Erber, B. Engelhardt, D. Vestweber and A. K. Hatzopoulos (2003) Multistep nature of microvascular recruitment of ex vivo expanded embryonic endothelial progenitor cells during tumor angiogenesis. J. Exp. Med. 197:1755-1765
2002
R. Nawroth, G. Poell, A. Ranft, S. Kloep, U. Samulowitz, G. Fachinger, M. Golding, D.T. Shima, U. Deutsch, and D. Vestweber (2002) VE-PTP and VE-cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts. EMBO J. 21: 4885-4895
2001
K. Lühn, M.K. Wild, M. Eckhardt, R. Gerardy-Schahn and D. Vestweber (2001) The defective gene in leukocyte adhesion deficiency II codes for a GDP-fucose transporter. Nat. Genet. 28:69-72
K. Ebnet, A. Suzuki, Y. Horikoshi, T. Hirose, M.-K. Meyer-zu-Brickwedde, S. Ohno and D. Vestweber (2001) The cell polarity protein ASIP/PAR-3 directly associates with Junctional Adhesion Molecule (JAM). EMBO J. 20: 3738-3748 (2001)
2000
W. Baumgartner, P. Hinterdorfer, W. Ness, A. Raab, D. Vestweber, H. Schindler, and D. Drenckhahn (2000) Cadherin interaction probed by atomic force microscopy. Proc. Natl. Acad. Sci. USA 97:4005-4010
1999
T. Marquardt, K. Lühn, G. Srikrishna, H.H. Freeze, E. Harms, and D. Vestweber (1999) Correction of Leukocyte Adhesion Deficiency Type II with oral fucose. Blood 94:3976-3985
S.M. Morgan, U. Samulowitz, L. Darley, D.L. Simmons, and D. Vestweber (1999) Biochemical characterization and molecular cloning of a novel endothelial specific sialomucin. Blood 93: 165-175
1998
T. Moll, E. Dejana, and D. Vestweber (1998) In vitro degradation of endothelial catenins by a neutrophil protease. J. Cell Biol. 140:403-407
J. Alferink, A. Tafuri, D. Vestweber, R. Hallmann, G.J. Hämmerling, and B. Arnold (1998) Control of neonatal tolerance to tissue-antigens by peripheral T cell trafficking. Science 282: 1338-1341
1997
F. Austrup, D. Vestweber, E. Borges, M. Löhning, R. Bräuer, R. Hallmann, A. Scheffold, A. Radbruch, and A. Hamann (1997) P- and E-selectin mediate recruitment of T helper 1 but not of T helper 2 cells into inflamed tissues. Nature 385, 81-83
O. Zöllner, M.C. Lenter, J.E. Blanks, E. Borges, M. Steegmaier, H.-G. Zerwes, and D. Vestweber (1997) L-selectin from human but not from mouse neutrophils binds directly to E-selectin. J. Cell Biol. 136, 707-715
E. Borges, W. Tietz, M. Steegmaier, T. Moll, R. Hallmann, A. Hamann, and D. Vestweber (1997) PSGL-1 on T helper 1 but not on T helper 2 cell binds to P-selectin and supports migration into inflamed skin. J. Exp. Med. 185: 573-578
E. Borges, R. Eytner, T. Moll, M. Steegmaier, MA Campbell, K. Ley, H. Mossmann, and D. Vestweber (1997) The P-selectin glycoprotein ligand-1 is important for recruitment of neutrophils into inflamed mouse peritoneum. Blood 90: 1934-1942
M. Steegmaier, E. Borges, J. Berger, H. Schwarz, and D. Vestweber (1997) The E-selectin ligand ESL-1 is located in the Golgi as well as on microvilli on the cell surface. J. Cell Science. 110: 687-694
1996
O. Zöllner, and D. Vestweber (1996) The E-selectin Ligand-1 is selectively activated in CHO cells by the α(1,3)-Fucosyltransferase IV and VII. J. Biol. Chem. 271: 33002-33008
E.J. Kunkel, U. Jung, D.C. Bullard, K.E. Norman, B.A. Wolitzky, D. Vestweber, A.L. Beaudet and K. Ley (1996) Absence of Trauma-induced leukocyte rolling in mice deficient in both P-selectin and ICAM-1. J. Exp. Med. 183: 57-65
G. Breier, F. Breviario, L. Caveda, R. Berthier, H. Schnürch, U. Gotsch, D. Vestweber, W. Risau and E. Dejana (1996) Molecular cloning and expression of murine Vascular Endothelial Cadherin in early stage development of cardiovascular system. Blood 87: 630-641
1995
M. Steegmaier, A. Levinovitz, S. Isenmann, E. Borges, M. Lenter, H. Kocher, B. Kleuser and D. Vestweber (1995) The E-selectin-ligand ESL-1 is a variant of a receptor for fibroblast growth factor. Nature373: 615-620
K. Ley, D. Bullard, M.L. Arbones, R. Bosse, D. Vestweber, T. Tedder and A. Beaudet (1995) Sequential contribution of P- and L-selectin to leukocyte rolling in vivo. J. Exp. Med. 181: 669-675
1994
R. Bosse and D. Vestweber (1994) Only blocking of L- and P-selectin completely blocks neutrophil migration into mouse peritoneum. Eur. J. Immunol. 24: 3019-3024
M. Lenter and D. Vestweber (1994) The integrin chains β1 and a6 associate with the chaperone calnexin prior to integrin assembly. J. Biol. Chem. 269: 12263 - 12268
M. Lenter, A. Levinovitz, S. Isenmann and D. Vestweber (1994) Monospecific and common glycoprotein ligands for E- and P-selectin on myeloid cells. J. Cell Biol. 125: 471 - 481
1993
M. Lenter, H. Uhlig, A. Hamann, P. Jenö, B. Imhof and D. Vestweber (1993) A monoclonal antibody against an activation epitope on mouse integrin chain β1 blocks adhesion of lymphocytes to the endothelial integrin a6β1. Proc. Natl. Acad. Sci. USA 90: 9051-9055
A. Levinovitz, J. Mühlhoff, S. Isenmann and D. Vestweber (1993) Identification of a glycoprotein ligand for E-selectin on mouse myeloid cells. J. Cell Biol. 121, 449-459 (1993)
M. Hahne, U. Jäger, S. Isenmann, R. Hallmann and D. Vestweber (1993) Five TNF-inducible cell adhesion mechanisms on the surface of mouse endothelioma cells mediate the binding of leukocytes. J. Cell Biol. 121: 655-664
1992
A. Weller, S. Isenmann and D. Vestweber (1992) Cloning of the mouse endothelial selectins: Expression of both E- and P-selectin is inducible by tumor necrosis factor a. J. Biol. Chem. 267: 15176-15183
1990
K.P. Baker, A. Schaniel, D. Vestweber and G. Schatz (1990) A yeast mitochondrial outer membrane protein essential for protein import and cell viability. Nature 348: 605-609
P.E. Scherer, U.C. Krieg, S.T. Hwang, D. Vestweber and G. Schatz (1990) A precursor protein partly translocated into yeast mitochondria is bound to a 70kD mitochondrial stress protein.EMBO J. 9: 4315-4322
1989
D. Vestweber and G. Schatz (1989) Blockage and quantification of mitochondrial protein import sites by an internally crosslinked hybrid precursor protein. Nova acta Leopoldina 61: 409-416
D. Vestweber and G. Schatz (1989) DNA-protein conjugates can enter mitochondria via the protein import pathway. Nature 338: 170-172
D. Vestweber, J. Brunner, A. Baker and G. Schatz (1989) A 42K outer membrane protein is a component of the yeast mitochondrial protein import site. Nature 341: 205-209
1988
D. Vestweber and G. Schatz (1988) Point mutations destabilizing a precursur protein enhance its post-translational import into mitochondria. EMBO J. 7: 1147-1151
D. Vestweber and G. Schatz (1988) Mitochondria can import artificial precursor proteins containing a branched polypeptide chain or a carboxy-terminal stilbene disulfonate J. Cell Biol. 107: 2045-2049
D. Vestweber and G. Schatz (1988) A chimeric mitochondrial precursor protein with internal disulfide bridges blocks import of authentic precursors into mitochondria and allows quantitation of import sites. J. Cell Biol. 107: 2037-2043
1987
M. Ringwald, R. Schuh, D. Vestweber, H. Eistetter, F. Lottspeich, J. Engel, R. Dölz, F. J. Jähnig, J. Epplen, S. Mayer, C. Müller and R. Kemler (1987) The structure of cell adhesion molecule uvomorulin. Insights into the molecular mechanism of calcium dependent cell adhesion. EMBO J. 6: 3647-3653
D. Vestweber, A. Gossler, K. Boller and R. Kemler (1987) Expression and distribution of cell adhesion molecule uvomorulin in mouse preimplantation embryos Dev. Biol. 124: 451-456
1986
R. Schuh, D. Vestweber, I. Riede, U.B. Rosenberg, H. Jäckle and R. Kemler (1986) Molecular cloning of mouse cell adhesion molecule uvomorulin: cDNA contains a B1 related sequence. Proc. Natl. Acad. Sci. USA 83: 1364-1368
1985
D. Vestweber and R. Kemler (1985) Identification of a putative cell adhesion domain of uvomorulin. EMBO J. 4: 3393-3398
D. Vestweber, R. Kemler and P. Ekblom (1985) Cell adhesion molecule uvomorulin during kidney development. Dev. Biol. 112: 213-221
D. Vestweber, C. Ocklind, A. Gossler, P. Odin, B. Öbrink and R. Kemler (1985) Comparison of two cell adhesion molecules, uvomorulin and cell-CAM 105. Exp. Cell Res. 157: 451-461
K. Boller, D. Vestweber and R. Kemler (1985) Cell adhesion molecule uvomorulin is localized in the indermediate junctions of adult intestinal epithelial cells. J. Cell Biol. 100: 327-332
1984
D. Vestweber and R. Kemler (1984) Rabbit antiserum against a purified surface glycoprotein decompacts mouse preimplantation embryos and reacts with specific adult tissues. Exp. Cell Res. 152: 169-178
D. Vestweber and R. Kemler (1984) Some structural and functional aspects of the cell adhesion molecule uvomorulin. Cell Differentiation 15: 269-273