Excluding Oct4 from Yamanaka Cocktail Unleashes the Developmental Potential of iPSCs Sergiy Velychko, Kenjiro Adachi, Kee-Pyo Kim, Yanlin Hou, Caitlin M. MacCarthy, Guangming Wu, Hans R. Schöler Cell Stem Cell 25(6):737–753
In this issue, Velychko et al. (737–753) found that omitting Oct4 from the reprogramming cocktail generates mouse iPSCs with the developmental potential equivalent to that of ESCs, which are considered the gold standard. The illustration depicts Oct4 as an elephant in the room—it is not only unnecessary, but even detrimental, for the reprogramming process. Cover artwork by Leah Saulnier.