Publications

Complete lists of publications can be found on:

• PubMed
• ResearchGate
• Web of Science

 

Selected recent publications

Kraft M, Schoofs H, Petkova M, Andrade J, Grosso AR, Benedito R, De Roo AK, Boon LM, Vikkula M, Kapp FG, Hägerling R, Potente M, Mäkinen T. Angiopoietin-TIE2 feedforward circuit promotes PIK3CA-driven venous malformations. Nat Cardiovasc Res (2025). May 23. doi: 10.1038/s44161-025-00655-9. Online ahead of print. PMID: 40410415

Schoofs H, Daubel N, Schnabellehner S, Grönloh MLB, Palacios Martínez S, Halme A, Marks AM, Jeansson M, Barcos S, Brakebusch C, Benedito R, Engelhardt B, Vestweber D, Gaengel K, Linsenmeier F, Schürmann S, Saharinen P, van Buul JD, Friedrich O, Smith RS, Majda M, Mäkinen T. Dynamic cytoskeletal regulation of cell shape supports resilience of lymphatic endothelium. Nature (2025). doi.org/10.1038/s41586-025-08724-6

Garcia-Gonzalez I, Gambera S, Rocha SF, Regano A, Garcia-Ortega L, Lytvyn M, Diago-Domingo L, Sanchez-Muñoz MS, Garcia-Cabero A, Zagorac I, Luo W, Fernández-Chacón M, Casquero-Garcia V, Francesca Lunella F, Torroja C, Sánchez-Cabo F, Benedito R. iFlpMosaics enable the multispectral barcoding and high-throughput comparative analysis of mutant and wild-type cells. Nature Methods (2025). doi:10.1038/s41592-024-02534-w

Garcia-Gonzalez I, Rocha SF, Hamidi A, Garcia-Ortega L, Regano A, Sanchez-Muñoz MS, Lytvyn M, Garcia-Cabero A, Roig-Soucase S, Schoofs H, Castro M, Sabata H, Potente M, Graupera M, Makinen T, Benedito R. iSuRe-HadCre is an essential tool for effective conditional genetics. Nucleic Acids Research (2024). doi:10.1093/nar/gkae472

Thambyrajah R, Maqueda M, Neo WH, Imbach K, Guillen Y, Grases D, Fadlullah Z, Gambera S, Matteini F, Wang X, … Benedito R, … Anna Bigas. Cis inhibition of NOTCH1 through JAGGED1 sustains embryonic hematopoietic stem cell fate. Nature Communications (2024), 15, 1604.

Cuervo H, Muhleder S, Garcia-Gonzalez I, Benedito R. Notch-mediated cellular interactions between vascular cells. Curr Opin Cell Biol (2023) 85, 102254. 10.1016/j.ceb.2023.102254.

Zarkada G, Chen X, …, Benedito R., Claesson-Welsh L, Alitalo K, Simons M, Ju R, Li X, Eichmann A, Zhang F. Chylomicrons Regulate Lacteal Permeability and Intestinal Lipid Absorption. Circulation Research (2023). 133:333–349.

Benedito R and Fernández-Chacón M. Transcriptional states do not always predict vascular function and pathology. Nature Cardiovascular Research (2023) 2 (6), pp. 498–499

Fernández-Chacón M, Mühleder S, Regano A, Garcia-Ortega L, Rocha SF, Torroja C, Sanchez-Muñoz MS, Lytvyn M, Casquero-Garcia V, Benedito R. Incongruence between transcriptional and vascular pathophysiological cell states. Nature Cardiovascular Research (2023). 10.1038/s44161-023-00272-4.

*WERNER RISAU PRIZE 2023 (for Macarena Fernández-Chacón) for outstanding study in vascular biology*.

Diago-Domingo L, Cuervo H, Benedito R. BMPing up endocardial angiogenesis to generate coronary vessels. Dev Cell. (2022) Nov 21;57(22):2515–2516.

Bernier-Latmani J, Cisarovsky C, …, Benedito R, Valet P, Zhou B, De Palma M, Delorenzi M, Sempoux C, Petrova TV. Apelin-driven endothelial cell migration sustains intestinal progenitor cells and tumor growth. Nature Cardiovasc. Res. (2022) May;1(5):476–490.

Monelli E, Villacampa P, Zabala-Letona A, Martinez-Romero A, …, Garcia-Gonzalez I, …, Benedito R, Garcia-Roves P, Vidal J, Cohen P, Nogueiras R, Claret M, Carracedo A, Graupera M. Angiocrine polyamine production regulates adiposity. Nature Metabolism (2022) Mar 14.

Lange M, Ohnesorge N, Hoffmann D, Rocha SF, Benedito R, Siekmann A. Zebrafish mutants in vegfab can affect endothelial cell proliferation without altering ERK phosphorylation and are phenocopied by loss of PI3K signaling. Dev. Biol. (2022) Jun;486:26–43.

Muhleder S, Benedito R. An RNA helicase swirls in lymphangiogenesis. Nature Cell Biology (2021) 23, 1109–1110.

Fernandez-Chacón M, Garcia-Gonzalez I, Muhleder S, Benedito R. Role of Notch in endothelial biology. Angiogenesis (2021) 24, 237–250.

Mühleder S, Fernández-Chacón M, Garcia-Gonzalez I, Benedito R. Endothelial sprouting, proliferation, or senescence: tipping the balance from physiology to pathology. Cell Mol Life Sci (2021) 78:1329–54

Garcia-Gonzalez I, Benedito R. Intricacies of conditional genetics in vascular biology. Curr Opin Hematol (2021) 28:189–197

Luo W, Garcia-Gonzalez I, Fernández-Chacón M, Casquero-Garcia V, Sanchez-Muñoz M, Mühleder S, Garcia-Ortega L, Andrade J, Potente M, Benedito R. Arterialization requires the timely suppression of cell growth. Nature (2021) 589:437–441.

TUCKER COLLINS VASCULAR BIOLOGY AWARD 2022 – Harvard Medical School, Boston, USA.

Garcia-Gonzalez I, Mühleder S, Fernández-Chacón M, Benedito R. Genetic Tools to Study Cardiovascular Biology. Front Physiol (2020) 11:1084

Crespo M, Gonzalez-Teran B, Nikolic I, Mora A, Folgueira C, Rodríguez E, … Benedito R, … et al. Neutrophil infiltration regulates clock-gene expression to organize daily hepatic metabolism. eLife (2020);9:e59258.

Fernández-Chacón M, Casquero-García V, Luo W, Lunella F, Rocha SF, Del Olmo-Cabrera S, Benedito R. iSuRe-Cre is a genetic tool to reliably induce and report Cre-dependent genetic modifications. Nature Commun. (2019). May 22;10, 2262.

Pontes-Quero S, Fernández-Chacón M, Luo W, Lunella F, Casquero-García V, Garcia-Gonzalez I, Bansal M, Hermoso A, Benedito R. High mitogenic stimulation arrests angiogenesis. Nature Commun. (2019). May 1;10, 2016.

Lim R, Sugino T, Nolte H, Andrade J, Zimmermann B, Shi C, Doddaballapur A, Ong YT, Wilhelm K, Fasse JWD, Ernst A, Kaulich M, Husnjak K, Boettger T, Guenther S, Braun T, Krüger M, Benedito R, Dikic I, Potente M. Deubiquitinase USP10 regulates Notch signaling in the endothelium. Science (2019), Apr 12;364(6436):188–193.

Menchero S, Rollan I, Lopez-Izquierdo A, Andreu MJ, Sainz de Aja J, Kang M, Adan J, Benedito R, Rayon T, Hadjantonakis AK, Manzanares M. Transitions in cell potency during early mouse development are driven by Notch. Elife (2019) Apr 8;8. pii: e42930.

Poulsen LC, Edelmann RJ, Krüger S, Diéguez-Hurtado R, Shah A, Stav-Noraas TE, Renzi A, Szymanska M, Wang J, Ehling M, Benedito R, Kasprzycka M, Bækkevold E, Sundnes O, Midwood KS, Scott H, Collas P, Siebel CW, Adams RH, Haraldsen G, Sundlisæter E, Hol J. Inhibition of Endothelial NOTCH1 Signaling Attenuates Inflammation by Reducing Cytokine-Mediated Histone Acetylation at Inflammatory Enhancers. Arterioscler Thromb Vasc Biol (2018) Apr;38(4):854–869.

Pontes-Quero S, Heredia L, Casquero-García V, Fernández-Chacón M, Luo W, Hermoso A, Bansal M, Garcia-Gonzalez I, Sanchez-Muñoz MS, Perea JR, Galiana-Simal A, Rodriguez-Arabaolaza I, Del Olmo-Cabrera S, Rocha SF, Criado-Rodriguez LM, Giovinazzo G, Benedito R. Dual ifgMosaic: A Versatile Method for Multispectral and Combinatorial Mosaic Gene-Function Analysis. Cell. (2017). Aug 10;170(4):800–814.