Molecular mechanisms of inflammation
Research report (imported) 2012 - Max Planck Institute for Molecular Biomedicine
Leukocyte recruitment into tissue forms the basis of immune surveillance and proceeds in a cascade-like fashion. The first contact of leukocytes with the endothelium is mediated by selectins and their counter receptors, followed by rolling and integrin-mediated arrest. Rolling leukocytes collect different inflammatory signals that can activate signaling pathways leading to leukocyte adhesion and transmigration. Several pathways exist that ensure rapid and efficient integrin activation on leukocytes. On the other hand, mechanisms that counteract and balance integrin activation also exist.