Chromatin Architecture During Early Embryonic Development

Research report (imported) 2017 - Max Planck Institute for Molecular Biomedicine

Vaquerizas, Juan M.
Abteilung Regulatory Genomics
The correct three-dimensional organisation of chromatin in the nucleus is a fundamental requirement for the proper functioning of the genome. As such, mutations in elements that determine this architecture lead to developmental disorders and cancer. In this work, chromatin conformation profiling in tightly staged Drosophila embryos revealed a dramatic reorganisation of chromatin that coincides with the zygotic genome activation.

For the full text, see the German version.

Go to Editor View