Original articles and reviews


McDonald M, Sebinger D, Brauns L, Gonzalez-Cano L, Menuchin-Lasowski Y, Mierzejewski M, Psathaki OE, Stumpf A, Wickham J, Rauen T, Schöler H, Jones PD. A mesh microelectrode array for non-invasive electrophysiology within neural organoids. Biosens Bioelectron. 228:115223, 2023

Xu G, Fatima A, Breitbach M, Kuzmenkin A, Fügemann CJ, Ivanyuk D, Kim KP, Cantz T, Pfannkuche K, Schöler HR, Fleischmann BK, Hescheler J, Šarić T. Electrophysiological Properties of Tetraploid Cardiomyocytes Derived from Murine Pluripotent Stem Cells Generated by Fusion of Adult Somatic Cells with Embryonic Stem Cells. Int J Mol Sci. 24(7):6546, 2023

Jeong D, Lee Y, Lee SW, Ham S, Lee M, Choi NY, Wu G, Scholer HR, Ko K. Homogeneity of XEN Cells Is Critical for Generation of Chemically Induced Pluripotent Stem Cells. Mol Cells. 46(4):209-218, 2023

Korn L, Speicher AM, Schroeter CB, Gola L, Kaehne T, Engler A, Disse P, Fernández-Orth J, Csatári J, Naumann M, Seebohm G, Meuth SG, Schöler HR, Wiendl H, Kovac S, Pawlowski M. MAPT genotype-dependent mitochondrial aberration and ROS production trigger dysfunction and death in cortical neurons of patients with hereditary FTLD. Redox Biol. 59:102597, 2023

Kim M, Park J, Kim S, Han DW, Shin B, Schöler HR, Kim J, Kim KP. Generation of Induced Pluripotent Stem Cells from Lymphoblastoid Cell Lines by Electroporation of Episomal Vectors. Int J Stem Cells. 16(1):36-43, 2023


Sathyanarayanan A, Ing-Simmons E, Chen R, Jeong HW, Ozguldez HO, Fan R, Duethorn B, Kim KP, Kim YU, Stehling M, Brinkmann H, Schöler HR, Adams RH, Vaquerizas JM, Bedzhov I. Early developmental plasticity enables the induction of an intermediate extraembryonic cell state. Science Advances 8(44):eabl9583 doi: 10.1126/sciadv.abl9583, 2022

Seo BJ, Hong TK, Yoon SH, Song JH, Uhm SJ, Song H, Hong K, Schöler HR, Do JT. Embryonic Stem Cells Lacking DNA Methyltransferases Differentiate into Neural Stem Cells that Are Defective in Self-Renewal. Int J Stem Cells doi: 10.15283/ijsc22138, 2022

MacCarthy CM, Huertas J, Ortmeier C, vom Bruch H, Tan DS, Reinke D, Sander A, Bergbrede T, Jauch R, Schöler HR and Cojocaru V. OCT4 interprets and enhances nucleosome flexibility. Nucleic Acids Research 50(18):10311-10327, 2022

Speicher AM, Korn L, Csatári J, Gonzalez-Cano L, Heming M, Thomas C, Schroeter CB, Schafflick D, Li X, Gola L, Engler A, Kaehne T, Vallier L, Meuth SG, Meyer zu Hörste G, Kovac S, Wiendl H, Schöler HR, Pawlowski M. Deterministic programming of human pluripotent stem cells into microglia: a versatile platform for studying microglia in health and disease. PNAS 119 (43) e2123476119, 2022

Nam D, Park MR, Lee H, Bae SC, Gerovska D, Araúzo-Bravo MJ, Zaehres H, Schöler HR, Kim JB. Induced Endothelial Cell-Integrated Liver Assembloids Promote Hepatic Maturation and Therapeutic Effect on Cholestatic Liver Fibrosis. Cells 11(14):2242, 2022

Doeser MC, Krygin J, Röpke A, Han D, Wedlich-Söldner R, Schöler HR, Pavenstädt H, Kim KP. Generation of a human iPSC line (MPIi008-A) from a patient with Denys-Drash syndrome. Stem Cell Res. 62:102826, 2022

Xiong L, Tolen EA, Choi J, Velychko S, Caizzi L, Velychko T, Adachi K, MacCarthy CM, Lidschreiber M, Cramer P, Schöler HR. Oct4 differentially regulates chromatin opening and enhancer transcription in pluripotent stem cells. Elife. 11:e71533, 2022

Eliat F, Sohn R, Renner H, Kagermeier T, Volkery S, Brinkmann H, Kirschnick N, Kiefer F, Grabos M, Becker K, Bedzhov I, Schöler HR, Bruder JM. Tissue clearing may alter emission and absorption properties of common fluorophores. Sci Rep. 12(1):5551, 2022

Menuchin-Lasowski Y, Schreiber A, Lecanda A, Mecate-Zambrano A, Brunotte L, Psathaki OE, Ludwig S, Rauen T, Schöler HR. SARS-CoV-2 infects and replicates in photoreceptor and retinal ganglion cells of human retinal organoids. Stem Cell Reports. 217(4):789-803, 2022

Han D, Wu G, Chen R, Drexler HCA, MacCarthy CM, Kim KP, Adachi K, Gerovska D, Mavrommatis L, Bedzhov I, Araúzo-Bravo MJ, Schöler HR. A balanced Oct4 interactome is crucial for maintaining pluripotency. Sci Adv. 8(7):eabe4375,  2022


Duong CN, Brückner R, Schmitt M, Nottebaum AF, Braun LJ, Meyer Zu Brickwedde M, Ipe U, Vom Bruch H, Schöler HR, Trapani G, Trappmann B, Ebrahimkutty MP, Huveneers S, de Rooij J, Ishiyama N, Ikura M, Vestweber D. Force-induced changes of α-catenin conformation stabilize vascular junctions independently of vinculin. J Cell Sci. 15;134(24): jcs259012, 2021

Harberts J, Bours K, Siegmund M, Hedrich C, Glatza M, Schöler HR, Haferkamp U, Pless O, Zierold R, Blick RH. Culturing human iPSC-derived neural progenitor cells on nanowire arrays: mapping the impact of nanowire length and array pitch on proliferation, viability, and membrane deformation. Nanoscale 13(47):20052-20066, 2021

Kagiwada S, Aramaki S, Wu G, Shin B, Kutejova E, Obridge D, Adachi K, Wrana JL, Hübner K, Schöler HR. YAP creates epiblast responsiveness to inductive signals for germ cell fate. Development. 148, doi:10.1242/dev.199732, 2021

Chen Y, Lüttmann FF, Schoger E, Schöler HR, Zelarayán LC, Kim KP, Haigh JJ, Kim J, Braun T. Reversible reprogramming of cardiomyocytes to a fetal state drives heart regeneration in mice. Science. 373(6562):1537-1540, 2021

Mall EM, Lecanda A, Drexler HCA, Raz E, Schöler HR, Schlatt S. Heading towards a dead end: The role of DND1 in germ line differentiation of human iPSCs. PLoS One. 16(10), 2021

Badanjak K, MulicaP, Smajic S, Delcambre S, Tranchevent LC, Diederich N, Rauen T, Schwamborn JC, Glaab E, Cowley SA, Antony PMA, Pereira SL, Venegas C, Grünewald A. iPSC-Derived Microglia as a Model to Study Inflammation in Idiopathic Parkinson’s Disease. Frontiers in Cell and Developmental Biology, Volume 9, Article 740758, 2021

Salewskij K, Gross-Thebing T, Ing-Simmons E, Duethorn B, Rieger B, Fan R, Chen R, Govindasamy N, Brinkmann H, Kremer L, Kuempel-Rink N, Mildner K, Zeuschner D, Stehling M, Dejosez M, Zwaka TP, Schöler HR, Busch KB, Vaquerizas JM, Bedzhov I. Ronin governs the metabolic capacity of the embryonic lineage for post-implantation development. EMBO Rep. 22(11):e53048, 2021

Renner H, Schöler HR, Bruder JM. Combining Automated Organoid Workflows With Artificial Intelligence-Based Analyses: Opportunities to Build a New Generation of Interdisciplinary High-Throughput Screens for Parkinson's Disease and Beyond. Mov Disord. doi: 10.1002/mds.28775, 2021. Mov Disord. 36(12):2745-2762, 2021

Aramaki S, Kagiwada S, Wu G, Obridge D, Adachi K, Kutejova E, Lickert H, Hübner K, Schöler HR. Residual pluripotency is required for inductive germ cell segregation. EMBO Rep. 22(8), 2021

Kim KP, Li C, Bunina D, Jeong HW, Ghelman J, Yoon J, Shin B, Park H, Han DW, Zaugg JB, Kim J, Kuhlmann T, Adams RH, Noh KM, Goldman SA, Schöler HR. Donor cell memory confers a metastable state of directly converted cells. Cell Stem Cell. 28(7):1291-1306, 2021

Liu Y, Chen Q, Han D, Schöler H, Fabian J, Stehling M, Jeong HW, Drexler HCA, Adams RH. Dopamine signaling regulates hematopoietic stem and progenitor cell function. Blood 138 (21): 2051–2065, 2021

Renner H, Becker KJ, Kagermeier TE, Grabos M, Eliat F, Günther P, Schöler HR, Bruder JM. Cell-Type-Specific High Throughput Toxicity Testing in Human Midbrain Organoids. Front Mol Neurosci. 15;14:715054, 2021

Renner H, Grabos M, Schöler HR, Bruder JM. Generation and Maintenance of Homogeneous Human Midbrain Organoids. Bio Protoc. 11(11), 2021

Kim KP, Han DW, Kim J, Schöler HR. Biological importance of OCT transcription factors in reprogramming and development. Exp Mol Med. 53(6):1018-1028, 2021 

Chanoumidou K, Hernández-Rodríguez B, Windener F, Thomas C, Stehling M, Mozafari S, Albrecht S, Ottoboni L, Antel J, Kim KP, Velychko S, Cui QL, Xu YKT, Martino G, Winkler J, Schöler HR, Baron-Van Evercooren A, Boespflug-Tanguy O, Vaquerizas JM, Ehrlich M, Kuhlmann T. One-step Reprogramming of Human Fibroblasts into Oligodendrocyte-like Cells by SOX10, OLIG2, and NKX6.2. Stem Cell Reports. 16(4):771-783, 2021 

Tan DS, Chen Y, Gao Y, Bednarz A, Wei Y, Malik V, Ho DH, Weng M, Ho SY, Srivastava Y, Velychko S, Yang X, Fan L, Kim J, Graumann J, Stormo GD, Braun T, Yan J, Schöler HR, Jauch R. Directed Evolution of an Enhanced POU Reprogramming Factor for Cell Fate Engineering. Mol Biol Evol. 38(7):2854-2868, 2021 

Huertas J, Schöler HR, Cojocaru V. Histone tails cooperate to control the breathing of genomic nucleosomes. PLoS Comput Biol. 17(6):e1009013. doi: 10.1371, 2021 

Hermann A, Wu G, Nedvetsky PI, Brücher VC, Egbring C, Bonse J, Höffken V, Wennmann DO, Marks M, Krahn MP, Schöler H, Heiduschka P, Pavenstädt H, Kremerskothen J. The Hippo pathway component Wwc2 is a key regulator of embryonic development and angiogenesis in mice. Cell Death Dis. 12(1):117, 2021

Renner H, Otto M, Grabos M, Schöler HR, Bruder JM. Fluorescence-based Single-cell Analysis of Whole-mount-stained and Cleared Microtissues and Organoids for High Throughput Screening. Bio-protocol 11(12), e4050-e40502021, 2021

Speicher AM, Korn L, Gonzalez-Cano L, Heming M, Thomas C, Kuhlmann T, Hoerste U, G Meyer G, Kovac S, Wiendl H, Meuth S, Schoeler H, Pawlowski M. Programming human pluripotent stem cells into microglia-a new model to study CNS disease. GLIA 69, E44, 2021

Mummery C, Little M, Lin H, Clark A, Zaret K; ISSCR Board 2020–2021, Srivastava D, Fuchs E, Watt F, Temple S. Mentorship in Science: Response to AlShebli et al., Nature Communications 2020. Stem Cell Reports 16(1):1-2, 2021

Kim KP, Choi J, Yoon JY, Bruder JM, Shin B, Kim JH, Arauzo-Bravo MJ, Han D, Wu G, Han DW, Kim J, Cramer P, Schöler HR. Permissive epigenomes endow reprogramming competence to transcriptional regulators. Nature Chemical Biology 17(47–56), 2021

Associated Content:


Mozafari S, Starost L, Manot-Saillet B, Garcia-Diaz B, Xu YKT, Roussel D, Levy MJF, Ottoboni L, Kim KP, Schöler HR, Kennedy TE, Antel JP, Martino G, Angulo MC, Kuhlmann T, Evercooren AB. Multiple sclerosis iPS-derived oligodendroglia conserve their properties to functionally interact with axons and glia in vivo. Sci Adv. 6(49), 2020

Liu FL, Wu K, Sun JY, Duan Z, Quan X, Kuang J, Chu S, Pang W, Gao H, Xu L, Li YC, Zhang HL, Wang XH, Luo RH, Feng XL, Schöler HR, Chen X, Pei D, Wu G*, Zheng YT*, Chen J. Rapid generation of ACE2 humanized inbred mouse model for COVID-19 with tetraploid complementation. National Science Review,, 2020

Renner H, Grabos M, Becker KJ, Kagermeier TE, Wu J, Otto M, Peischard S, Zeuschner D, TsyTsyura Y, Disse P, Klingauf J, Leidel SA, Seebohm G, Schöler HR, Bruder JM. A fully automated high-throughput workflow for 3D-based chemical screening in human midbrain organoids. eLife 9:e52904, 2020.

Fan R, Kim YS, Wu J, Chen R, Zeuschner D, Mildner K, Adachi K, Wu G, Galatidou S, Li J, Schöler HR, Leidel SA, Bedzhov I. Wnt/Beta-catenin/Esrrb signalling controls the tissue-scale reorganization and maintenance of the pluripotent lineage during murine embryonic diapause. Nat Commun. 11(1):5499, 2020

Mall EM, Rotte N, Yoon J, Sandhowe-Klaverkamp R, Röpke A, Wistuba J, Hübner K, Schöler HR, Schlatt S. A novel xeno-organoid approach: exploring the crosstalk between human iPSC-derived PGC-like and rat testicular cells. Mol Hum Reprod. doi: 10.1093/molehr/gaaa067, 2020

Kim KP, Yoon JY, Kim J, Röpke A, Shin B, Han DW, Greber B, Schöler HR. Generation of a human iPSC line (MPIi007-A) from a patient with Metachromatic leukodystrophy. Stem Cell Research 48, 101993, 2020

Starost L, Lindner M, Herold M, Xu YKT, Drexler HCA, Heß K, Ehrlich M, Ottoboni L, Ruffini F, Stehling M, Röpke A, Thomas C, Schöler HR, Antel J, Winkler J, Martino G, Klotz L, Kuhlmann T. Extrinsic immune cell-derived, but not intrinsic oligodendroglial factors contribute to oligodendroglial differentiation block in multiple sclerosis. Acta Neuropathol. 40(5):715-736, 2020

Kim KP, Wu Y, Yoon J, Adachi K, Wu G, Velychko S, MacCarthy CM, Shin B, Röpke A, Arauzo-Bravo MJ, Stehling M, Han DW, GaoY, Kim J, Gao S, Schöler HR. Reprogramming competence of OCT factors is determined by transactivation domains. Science Advances 6(36), 2020

Lee H, Lee HY, Lee BE, Gerovska D, Park SY, Zaehres H, Arauzo-Bravo MJ, Kim JI, Ha Y, Schöler HR, Kim JB. Sequentially induced motor neurons from human fibroblasts facilitate locomotor recovery in a rodent spinal cord injury model. eLife 2020;9:e52069, 2020

Chen K, Long Q, Xing G, Wang T, Wu Y, Li L, Qi J, Zhou Y, Ma B, Schöler HR, Nie J, Pei D, Liu X. Heterochromatin loosening by the Oct4 linker region facilitates Klf4 binding and iPSC reprogramming. EMBO J. 39(1), 2020

Choi NY, Bang JS, Park YS, Lee M, Hwang HS, Ko K, Myung SC, Tapia N, Schöler HR, Kim GJ, Ko K. Generation of human androgenetic induced pluripotent stem cells. Scientific Reports 10:3614, 2020

Huertas J, MacCarthy CM, Schöler HR, Cojocaru V. Nucleosomal DNA Dynamics Mediate Oct4 Pioneer Factor Binding. Biophys J 118(9):2280-2296, 2020

Kim KP, Yoon J, Shin B, Röpke A, Han DW, Schöler HR. Generation of a human iPSC line (MPIi006-A) from a patient with Pelizaeus-Merzbacher disease. Stem Cell Res. 46:101839, 2020

Yaoyi Li, Yawei Song, Wei Xu, Qin Li, Xinxiu Wang, Kuan Li, Juehan Wang, Zicong Liu, Sergiy Velychko, Rong Ye, Qing Xia1, Lei Wang, Rong Guo1, Xiaotao Dong, Zhikai Zheng, Yushuang Dai , Haojie Li, Mingze Yao, Yuanchao Xue, Hans R. Schöler, Qianwen Sun, Hongjie. R-loops coordinate with SOX2 in regulating reprogramming to pluripotency. Science Advances 6(24), 2020


Velychko S, Adachi K, Kim KP, Hou Y, MacCarthy CM, Wu G*, Schöler HR*. Excluding Oct4 from Yamanaka cocktail unleashes the developmental potential of iPSCs. Cell Stem Cell 25(6):737-753, 2019

Associated Content:

Gomez-Giro G, Arias-Fuenzalida J, Jarazo J, Zeuschner D, Ali M, Possemis N, Bolognin S, Halder R, Jäger C, Kuper WFE, van Hasselt PM, Zaehres H, Del Sol A, van der Putten H, Schöler HR, Schwamborn JC. Synapse alterations precede neuronal damage and storage pathology in a human cerebral organoid model of CLN3-juvenile neuronal ceroid lipofuscinosis. Acta Neuropathol Commun. 7(1):222, 2019

Chen K, Long Q, Xing G, Wang T, Wu Y, Li L, Qi J, Zhou Y, Ma B, Schöler HR, Nie J, Pei D, Liu X. Heterochromatin loosening by the Oct4 linker region facilitates Klf4 binding and iPSC reprogramming. EMBO J. e99165, 2019

Kremer L, Hennes E, Brause A, Ursu A, Robke L, Matsubayashi HT, Nihongaki Y, Flegel J, Mejdrová I, Eickhoff J, Baumann M, Nencka R, Janning P, Kordes S, Schöler HR, Sterneckert J, Inoue T, Ziegler S, Waldmann H. Discovery of the Hedgehog Pathway Inhibitor Pipinib that Targets PI4KIIIß. Angew Chem Int Ed Engl. 58(46):16617-16628, 2019

Srivastava Y, Tan DS, Malik V, Weng M, Javed A, Cojocaru V, Wu G, Veerapandian V, Cheung LW, Jauch R. Cancer-associated missense mutations enhance the pluripotency reprogramming activity of OCT4 and SOX17. FEBS J. 2287(1):122-144, 2019

Park MR, Wong MS, Araúzo-Bravo MJ, Lee H, Nam D, Park SY, Seo HD, Lee SM, Zeilhofer HF, Zaehres H, Schöler HR, Kim JB. Oct4 and Hnf4α-induced hepatic stem cells ameliorate chronic liver injury in liver fibrosis model. PLoS One 14(8):e0221085, 2019

Malik V, Glaser LV, Zimmer D, Velychko S, Weng M, Holzner M, Arend M, Chen Y, Srivastava Y, Veerapandian V, Shah Z, Esteban MA, Wang H, Chen J, Schöler HR, Hutchins AP, Meijsing SH, Pott S, Jauch R. Pluripotency reprogramming by competent and incompetent POU factors uncovers temporal dependency for Oct4 and Sox2. Nat Commun. 10(1):3477, 2019

Friese A, Ursu A, Hochheimer A, Schöler HR, Waldmann H, Bruder JM. The Convergence of Stem Cell Technologies and Phenotypic Drug Discovery. Cell Chem Biol. 26(8):1050-1066, 2019

Viplav A, Saha T, Huertas J, Selenschik P, Ebrahimkutty MP, Grill D, Lehrich J, Hentschel A, Biasizzo M, Mengoni S, Ahrends R, Gerke V, Cojocaru V, Klingauf J, Galic M. ArhGEF37 assists Dynamin2 during Clathrin-mediated endocytosis. J Cell Sci. doi: 10.1242/jcs.226530 [Epub ahead of print], 2019

Velychko S, Kang K, Kim SM, Kwak TH, Kim KP, Park C, Hong K, Chung CH, Hyun JK, MacCarthy CM, Wu G, Schöler HR*, Han DW*. Fusion of Reprogramming Factors Alters the Trajectory of Somatic Lineage Conversion. Cell Reports 27(1):30-39, 2019

Bakhmet EI, Nazarov IB, Gazizova AR, Vorobyova NE, Kuzmin AA, Gordeev MN, Sinenko SA, Aksenov ND, Artamonova TO, Khodorkovskii MA, Alenina N, Onichtchouk D, Wu G, Schöler HR, Tomilin AN. hnRNP-K targets open chromatin in mouse embryonic stem cells in concert with multiple regulators. Stem Cells 37(8):1018-1029, 2019

Hwang SI, Kwak TH, Kang JH, KiM J, Lee H, Kim KP, Ko K, Schöler HR, and Han DW. Metastable Reprogramming State of Single Transcription Factor-Derived Induced Hepatocyte-Like Cells. Stem Cells International, Article ID 6937257, 2019

Reinhardt L, Kordes S, Reinhardt P, Glatza M, Baumann M, Drexler HCA, Menninger S, Zischinsky G, Eickhoff J, Fröb C, Bhattarai P, Arulmozhivarman G, Marrone L, Janosch A, Adachi K, Stehling M, Anderson EN, Abo-Rady M, Bickle M, Pandey UB, Reimer MM, Kizil C, Schöler HR, Nussbaumer P, Klebl B, Sterneckert JL. Dual Inhibition of GSK3β and CDK5 Protects the Cytoskeleton of Neurons from Neuroinflammatory-Mediated Degeneration In Vitro and In Vivo. Stem Cell Reports 12(3):502-517, 2019


Adachi K, Kopp W, Wu G, Heising S, Greber B, Stehling M, Araúzo-Bravo MJ, Boerno ST, Timmermann B, Vingron M, Schöler HR. Esrrb Unlocks Silenced Enhancers for Reprogramming to Naive Pluripotency. Cell Stem Cell 23(2):266-275, 2018

Lee Y, Kim CY, Lee HJ, Kim JG, Han DW, Ko K, Walter J, Chung HM, Schöler HR, Bae YM, Ko K. Two-Step Generation of Oligodendrocyte Progenitor Cells From Mouse Fibroblasts for Spinal Cord Injury. Front Cell Neurosci . doi: 10.3389/fncel.2018.00198. eCollection 2018

Weider M, Starost LJ, Groll K, Küspert M, Sock E, Wedel M, Fröb F, Schmitt C, Baroti T, Hartwig AC, Hillgärtner S, Piefke S, Fadler T, Ehrlich M, Ehlert C, Stehling M, Albrecht S, Jabali A, Schöler HR, Winkler J, Kuhlmann T, Wegner M. Nfat/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning. Nat Commun. 9(1):899, 2018. Erratum in: Nat Commun. 9(1):1667, 2018

Lee SW, Wu G, Choi NY, Lee HJ, Bang JS, Lee Y, Lee M, Ko K, Schöler HR, Ko K. Self-Reprogramming of Spermatogonial Stem Cells into Pluripotent Stem Cells without Microenvironment of Feeder Cells. Mol Cells 41(7):631-638, 2018

Doeser MC, Schöler HR, Wu G. Reduction of Fibrosis and Scar Formation by Partial Reprogramming In Vivo. Stem Cells 36(8):1216-1225, 2018

Lim KT, Kim J, Hwang SI, Zhang L, Han H, Bae D, Kim KP, Hu YP, Schöler HR, Lee I, Hui L, Han DW. Direct Conversion of Mouse Fibroblasts into Cholangiocyte Progenitor Cells. Stem Cell Reports 10(5):1522-1536, 2018

Galonska C, Charlton J, Mattei AL, Donaghey J, Clement K, Gu H, Mohammad AW, Stamenova EK, Cacchiarelli D, Klages S, Timmermann B, Cantz T, Schöler HR, Gnirke A, Ziller MJ, Meissner A. Genome-wide tracking of dCas9-methyltransferase footprints. Nat Commun. 9(1):597, 2018

Höing S, Yeh TY, Baumann M, Martinez NE, Habenberger P, Kremer L, Drexler HCA, Küchler P, Reinhardt P, Choidas A, Zischinsky ML, Zischinsky G, Nandini S, Ledray AP, Ketcham SA, Reinhardt L, Abo-Rady M, Glatza M, King SJ, Nussbaumer P, Ziegler S, Klebl B, Schroer TA, Schöler HR, Waldmann H, Sterneckert J. Dynarrestin, a Novel Inhibitor of Cytoplasmic Dynein. Cell Chem Biol. 25(4):357-369, 2018

Luu PL, Gerovska D, Schöler HR, Araúzo-Bravo MJ. Rules governing the mechanism of epigenetic reprogramming memory. Epigenomics (2):149-174, 2018


Sharifi-Zarchi A, Gerovska D, Adachi K, Totonchi M, Pezeshk H, Taft RJ, Schöler HR, Chitsaz H, Sadeghi M, Baharvand H, Araúzo-Bravo MJ. DNA methylation regulates discrimination of enhancers from promoters through a H3K4me1-H3K4me3 seesaw mechanism. BMC Genomics 18(1):964, 2017

Arias-Fuenzalida J, Jarazo J, Qing X, Walter J, Gomez-Giro G, Nickels SL, Zaehres H, Schöler HR, Schwamborn JC. FACS-Assisted CRISPR-Cas9 Genome Editing Facilitates Parkinson's Disease Modeling. Stem Cell Reports 14;9(5):1423-1431, 2017

Choi HW, Joo JY, Hong YJ, Kim JS, Song H, Lee JW, Wu G, Schöler HR, Do JT. Distinct Enhancer Activity of Oct4 in Naive and Primed Mouse Pluripotency. Stem Cell Reports 7(5):911-926, 2017

Totonchi M, Hassani SN, Sharifi-Zarchi A, Tapia N, Adachi K, Arand J, Greber B, Sabour D, Araúzo-Bravo MJ, Walter J, Pakzad M, Gourabi H, Schöler HR, Baharvand H. Blockage of the Epithelial-to-Mesenchymal Transition Is Required for Embryonic Stem Cell Derivation. Stem Cell Reports 9(4):1275-1290, 2017

Kremer L, Schultz-Fademrecht C, Baumann M, Habenberger P, Choidas A, Klebl B, Kordes S, Schöler HR, Sterneckert J, Ziegler S, Schneider G, Waldmann H. Discovery of a Novel Inhibitor of the Hedgehog Signaling Pathway through Cell-based Compound Discovery and Target Prediction. Angew Chem Int Ed Engl. 56(42):13021-13025, 2017 

Jeong HW, Hernández-Rodríguez B, Kim J, Kim KP, Enriquez-Gasca R, Yoon J, Adams S, Schöler HR, Vaquerizas JM, Adams RH.Transcriptional regulation of endothelial cell behavior during sprouting angiogenesis. Nat Commun. 8(1):726, 2017

Kessel KU, Bluemke A, Schöler HR, Zaehres H, Schlenke P, Dorn I. Emergence of CD43-Expressing Hematopoietic Progenitors from Human Induced Pluripotent Stem Cells. Transfus Med Hemother. 44(3):143-150, 2017

Ursu A, Schöler HR, Waldmann H. Small-molecule phenotypic screening with stem cells. Nat Chem Biol. 13(6):560-563, 2017

van der Wal E, Bergsma AJ, van Gestel TJM, in ‘t Groen SLM, Zaehres H, Araúzo-Bravo MJ, Schöler HR, van der Ploeg AT. GAA deficiency in Pompe disease is alleviated by exon inclusion in iPS-derived skeletal muscle cells. Molecular Therapy: Nucleic Acid 16;7:101-115, 2017

Ehrlich M, Mozafari S, Glatza M, Starost L, Velychko S, Hallmann AL, Cui QL, Schambach A, Kim KP, Bachelin C, Marteyn A, Hargus G, Johnson RM, Antel J, Sterneckert J, Zaehres H, Schöler HR, Baron-Van Evercooren A, Kuhlmann T. Rapid and efficient generation of oligodendrocytes from human induced pluripotent stem cells using transcription factors. PNAS (11) E2243-E2252; 2017

Hallmann AL, Araúzo-Bravo MJ, Mavrommatis L, Ehrlich M, Röpke A, Brockhaus J, Missler M, Sterneckert J, Schöler HR, Kuhlmann T, Zaehres H, Hargus G. Astrocyte pathology in a human neural stem cell model of frontotemporal dementia caused by mutant TAU protein. Sci Rep. 3;7:42991, 2017

Wu G, Lei L, Schöler HR. Totipotency in the mouse. J Mol Med (Berl). 95(7):687-694, 2017

Neuhaus N, Yoon J, Terwort N, Kliesch S, Seggewiss J, Huge A, Voss R, Schlatt S, Grindberg RV, Schöler HR. Single-cell gene expression analysis reveals diversity among human spermatogonia. Mol Hum Reprod. 23(2):79-90, 2017

Luu PL, Gerovska D, Arrospide-Elgarresta M, Retegi-Carrión S, Schöler HR, Araúzo-Bravo MJ. P3BSseq: parallel processing pipeline software for automatic analysis of bisulfite sequencing data. Bioinformatics 33(3):428-431, 2017

Jerabek S, Ng CK, Wu G, Arauzo-Bravo MJ, Kim KP, Esch D, Malik V, Chen Y, Velychko S, MacCarthy CM, Yang X, Cojocaru V, Schöler HR, Jauch R. Changing POU dimerization preferences converts Oct6 into a pluripotency inducer. EMBO Rep. 18(2):319-333, 2017


Choi HW, Joo JY, Hong YJ, Kim JS, Song H, Lee JW, Wu G, Schöler HR, Do JT. Distinct Enhancer Activity of Oct4 in Naive and Primed Mouse Pluripotency. Stem Cell Reports 7(5):911-926, 2016

Chen K, Long Q, Wang T, Zhao D, Zhou Y, Qi J, Wu Y, Li S, Chen C, Zeng X, Yang J, Zhou Z, Qin W, Liu X, Li Y, Li Y, Huang X, Qin D, Chen J, Pan G, Schöler HR, Xu G, Liu X Pei D. Gadd45a is a heterochromatin relaxer that enhances iPS cell generation. EMBO Rep. 17(11):1641-1656, 2016

Shinya Yamanaka, Joao Monteiro and Hans Schöler. iPS Cells 10 Years Later. Cell. 166:1356-1359, 2016

Tapia N, Schöler HR. Molecular Obstacles to Clinical Translation of iPSCs. Cell Stem Cell 19(3):298-309, 2016

Öztürk M, Pachov G, Wade R, Cojocaru V. Conformational selection and dynamic adaptation upon linker histone binding to the nucleosome. Nucleic Acids Research 44(14):6599-613, 2016

Kim SM, Kim JW, Kwak TH, Park SW, Kim KP, Park H, Lim KT, Kang K, Kim J, Yang JH, Han H, Lee I, Hyun JK, Bae YM, Schöler HR, Lee HT, Han DW. Generation of Integration-free Induced Neural Stem Cells from Mouse Fibroblasts. J Biol Chem. 291(27):14199-212, 2016

Hallmann AL, Arauzo-Bravo MJ, Zerfass C, Senner V, Ehrlich M, Psathaki OE, Han DW, Tapia N, Zaehres H, Schöler HR, Kuhlmann T, Hargus G. Comparative transcriptome analysis in induced neural stem cells reveals defined neural cell identities in vitro and after transplantation into the adult rodent brain. Stem Cell Res. 16(3): 776–781, 2016

Lim KT, Lee SC, Gao Y, Kim KP, Song G, An SY, Adachi K, Jang YJ, Kim J, Oh KJ, Kwak TH, Hwang SI, You JS, Ko K, Koo SH, Sharma AD, Kim JH, Hui L, Cantz T, Schöler HR, Han DW. Small Molecules Facilitate Single Factor-Mediated Hepatic Reprogramming. Cell Reports 15(4):814-29, 2016

Preview on Illich et al. and Ursu et al.:

Russell AJ, Silpa L. Chemical-Induced Naive Pluripotency. Cell Chem Biol. 23(5):532-34, 2016

Illich DJ, Miao Z, Ursu A, Osorno R, Kim KP, Yoon JY, Arauzo-Bravo MJ, Wu G, Esch D, Sabour D, Colby D, Grassme KS, Chen J, Greber B, Höing S, Herzog W, Ziegler S, Chambers I, Gao S, Waldmann H, Schöler HR. Distinct Signaling Requirements for the Establishment of ESC Pluripotency in Late-Stage EpiSCs. Cell Reports 15, 787–800, 2016

Ursu A, Illich DJ, Takemoto Y, Porfetye AT, Zhang M, Brockmeyer A, Janning P, Watanabe N, Osada H, Vetter IR, Ziegler S, Schöler HR, Waldmann H. Epiblastin A Induces Reprogramming of Epiblast Stem Cells Into Embryonic Stem Cells by Inhibition of Casein Kinase 1. Cell Chem Biol. 21;23(4):494-507, 2016

Wu G, Schöler HR. Lineage Segregation in the Totipotent Embryo. Curr Top Dev Biol. 117:301-17, 2016

Lee HJ, Choi NY, Lee SW, Ko K, Hwang TS, Han DW, Lim J, Schöler HR, Ko K. Epigenetic alteration of imprinted genes during neural differentiation of germline-derived pluripotent stem cells. Epigenetics. 11(3):177-83, 2016

Song G, Pacher M, Balakrishnan A, Yuan Q, Tsay H-C, Yang D, Reetz J, Brandes S, Dai Z, Pützer BM, Arauzo-Bravo MJ, Steinemann D, Luedde T, Schwabe RF, Manns MP, Schöler HR, Schambach A, Cantz T, Ott M and Sharma AD. Direct Reprogramming of Hepatic Myofibroblasts into Hepatocytes In Vivo Attenuates Liver Fibrosis. Cell Stem Cell 18(6):797-808, 2016

Kim SM, Lim KT, Kwak TH, Lee SC, Im JH, Hali S, In Hwang S, Kim D, Hwang J, Kim KP, Chung HJ, Kim JB, Ko K, Chung HM, Lee HT, Schöler HR, Han DW. Induced neural stem cells from distinct genetic backgrounds exhibit different reprogramming status. Stem Cell Res. 16(2):460-468, 2016

Lee H, Nam D, Choi JK, Araúzo-Bravo MJ, Kwon SY, Zaehres H, Lee T, Park CY, Kang HW, Schöler HR, Kim JB. Establishment of feeder-free culture system for human induced pluripotent stem cell on DAS nanocrystalline graphene. Sci Rep. 6:20708, 2016

Hermann A, Kim JB, Srimasorn S, Zaehres H, Reinhardt P, Schöler HR, Storch A. Factor-Reduced Human Induced Pluripotent Stem Cells Efficiently Differentiate into Neurons Independent of the Number of Reprogramming Factors. Stem Cells International Volume 2016, Article ID 4736159, 2016

Marthaler AG, Adachi K, Tiemann U, Wu G, Sabour D, Velychko S, Kleiter I, Schöler HR, Tapia N. Enhanced OCT4 transcriptional activity substitutes for exogenous SOX2 in cellular reprogramming. Sci Rep. 14;6:19415, 2016

Rao J, Pfeiffer MJ, Frank S, Adachi K, Piccini I. Quaranta R, Araúzo-Bravo MJ, Schwarz J, Schade D, Leidel S, Schöler HR, Sebohm G, Greber B. Stepwise Clearance ot Repressive Roadblocks Drives Cardiac Induction in Human ESCs. Cell Stem Cell. 18(3):341–353, 2016

Tiemann U, Wu G, Marthaler AG, Schöler HR, Tapia N. Epigenetic Aberrations Are Not Specific to Transcription Factor-Mediated Reprogramming. Stem Cell Reports. 12;6(1):35-43, 2016


Russell R, Ilg M, Lin Q, Wu G, Lechel A, Bergmann W, Eiseler T, Linta L, Kumar P P, Klingenstein M, Adachi K, Hohwieler M, Sakk O, Raab S, Moon A, Zenke M, Seufferlein T, Schöler HR, Illing A, Liebau S, Kleger A. A Dynamic Role of TBX3 in the Pluripotency Circuitry. Stem Cell Reports. 5(6):1155-70, 2015

Kim J, Kim KP, Lim KT, Lee SC, Yoon J, Song G, Hwang SI, Schöler HR, Cantz T, Han DW. Generation of integration-free induced hepatocyte-like cells from mouse fibroblasts. Sci Rep. 5:15706, 2015

Kim JB, Lee H, Araúzo-Bravo MJ, Hwang H, Nam D, Park MR, Zaehres H, Park KI, Lee S-J. Oct4-induced oligodendrocyte progenitor cells enhance functional recovery in spinal cord injury model. EMBO J. 34:2971-2983, 2015

Tapia N, MacCarthy C, Esch D, Gabriele Marthaler A, Tiemann U, Araúzo-Bravo MJ, Jauch R, Cojocaru V, Schöler HR. Dissecting the role of distinct OCT4-SOX2 heterodimer configurations in pluripotency. Sci Rep. 5:13533, 2015

Ehrlich M, Hallmann AL, Reinhardt P, Araúzo-Bravo MJ, Korr S, Röpke A, Psathaki OE, Ehling P, Meuth SG, Oblak AL, Murrell JR, Ghetti B, Zaehres H, Schöler HR, Sterneckert J, Kuhlmann T, Hargus G. Distinct Neurodegenerative Changes in an Induced Pluripotent Stem Cell Model of Frontotemporal Dementia Linked to Mutant TAU Protein. Stem Cell Reports. 5(1):83-96, 2015

Sugawa F, Araúzo-Bravo MJ, Yoon J, Kim KP, Aramaki S, Wu G, Stehling M, Psathaki OE, Hübner K, Schöler HR. Human primordial germ cell commitment in vitro associates with a unique PRDM14 expression profile. EMBO J. 34(8):1009-24, 2015

Zhang M, Schulte JS, Heinick A, Piccini I, Rao J, Quaranta R, Zeuschner D, Malan D, Kim KP, Röpke A, Sasse P, Araúzo-Bravo M, Seebohm G, Schöler H, Fabritz L, Kirchhof P, Müller FU, Greber B. Universal Cardiac Induction of Human Pluripotent Stem Cells in 2D and 3D formats - Implications for In-Vitro Maturation. Stem Cells. 33(5):1456-69, 2015

López-Iglesias P, Alcaina Y, Tapia N, Sabour D, Arauzo-Bravo MJ, Sainz de la Maza D, Berra E, O'Mara AN, Nistal M, Ortega S, Donovan PJ, Schöler HR, De Miguel MP.
Hypoxia induces pluripotency in primordial germ cells by HIF1α stabilization and Oct4 deregulation. Antioxid Redox Signal. 22(3):205-23, 2015

Kim JS, Choi HW, Araúzo-Bravo MJ, Schöler HR, Do JT. Reactivation of inactive X chromosome and post-transcriptional reprogramming of Xist in induced pluripotent stem cells. J Cell Sci. 128(1):81-7, 2015

Dorn I, Klich K, Arauzo-Bravo MJ, Radstaak M, Santourlidis S, Ghanjati F, Radke TF, Psathaki OE, Hargus G, Kramer J, Einhaus M, Kim JB, Koegler G, Wernet P, Schöler HR, Schlenke P, Zaehres H. Erythroid differentiation of human induced pluripotent stem cells is independent of donor cell type of origin. Haematologica 100(1):32-41, 2015


Kim J, Eligehausen S, Stehling M, Nikol S, Ko K, Waltenberger J, Klocke R. Generation of functional endothelial-like cells from adult mouse germline-derived pluripotent stem cells. Biochem Biophys Res Commun. 10;443(2):700-5, 2014

Joo JY, Choi HW, Kim MJ, Zaehres H, Tapia N, Stehling M, Jung KS, Tae J, Schöler HR. Establishment of a primed pluripotent epiblast stem cell in FGF4-based conditions. Sci Rep. 4:7477, 2014

Fischedick G, Wu G, Adachi K, Araúzo-Bravo MJ, Greber B, Radstaak M, Köhler G, Tapia N, Iacone R, Anastassiadis K, Schöler HR, Zaehres H. Nanog induces hyperplasia without initiating tumors. Stem Cell Res. 13(2):300-15, 2014

Hong JY, Lee SH, Lee SC, Kim JW, Kim KP, Kim SM, Tapia N, Lim KT, Kim JH, Ahn HS, Ko K, Shin CY, Lee HT, Schöler HR, Hyun JK, Han DW. Therapeutic Potential of Induced Neural Stem Cells for Spinal Cord Injury. J Biol Chem. 289(47):32512-25, 2014

Hargus G, Ehrlich M, Araúzo-Bravo MJ, Hemmer K, Hallmann AL, Reinhardt P, Kim KP, Adachi K, Santourlidis S, Ghanjati F, Fauser M, Ossig C, Storch A, Kim JB, Schwamborn JC, Sterneckert J, Schöler HR, Kuhlmann T, Zaehres H. Origin-dependent neural cell identities in differentiated human iPSCs in vitro and after transplantation into the mouse brain. Cell Reports 8(6):1697-703, 2014

Heilker R, Traub S, Reinhardt P, Schöler HR, Sterneckert J. iPS cell derived neuronal cells for drug discovery. Trends Pharmacol Sciences 35(10):510-19, 2014

Hemmer K, Zhang M, van Wüllen T, Sakalem M, Tapia N, Baumuratov A, Kaltschmidt C, Kaltschmidt B, Schöler HR, Zhang W, Schwamborn JC. Induced neural stem cells achieve long-term survival and functional integration in the adult mouse brain. Stem Cell Reports 3(3):423-31, 2014

Merino F, Ng CKL, Veerapandian V, Schöler HR, Jauch R, Cojocaru V. Structural basis for the SOX-dependent genomic redistribution of OCT4 in stem cell differentiation. Structure 22:1–13, 2014

Frankenberg SR, Frank D, Harland R, Johnson AD, Nichols J, Niwa H, Schöler HR, Tanaka E, Wylie C, Brickman JM. The POU-er of gene nomenclature. Development 141(15):2921-3, 2014

Sabour D, Xu X, Chung AC, Le Menuet D, Ko K, Tapia N, Arauzo-Bravo MJ, Gentile L, Greber B, Hübner K, Sebastiano V, Wu G, Schöler HR, Cooney AJ. Germ cell nuclear factor regulates gametogenesis in developing gonads. PLoS One. 9(8):e103985, 2014

Sterneckert JL, Reinhardt P, Schöler HR. Investigating human disease using stem cell models. Nat Rev Genet 15:625-39

Choi NY, Park YS, Ryu JS, Lee HJ, Araúzo-Bravo MJ, Ko K, Han DW, Schöler HR, Ko K. A novel feeder-free culture system for expansion of mouse spermatogonial stem cells. Mol Cells 37(6):473-9, 2014

Hassani SN, Totonchi M, Sharifi-Zarchi A, Mollamohammadi S, Pakzad M, Moradi S, Samadian A, Masoudi N, Mirshahvaladi S, Farrokhi A, Greber B, Araúzo-Bravo MJ, Sabour D, Sadeghi M, Salekdeh GH, Gourabi H, Schöler HR, Baharvand H. Inhibition of TGFβ Signaling Promotes Ground State Pluripotency. Stem Cell Rev 10(1):16-30, 2014

Jerabek S, Merino F, Schöler HR, Cojocaru V. OCT4: Dynamic DNA binding pioneers stem cell pluripotency. Biochim Biophys Acta 1839(3):138-54, 2014

Kang E, Wu G, Ma H, Li Y, Tippner-Hedges R, Tachibana M, Sparman M, Wolf DP, Schöler HR, Mitalipov S. Nuclear reprogramming by interphase cytoplasm of two-cell mouse embryos. Nature 509(7498):101-4, 2014

Lojewski X, Staropoli JF, Biswas-Legrand S, Simas AM, Haliw L, Selig MK, Coppel SH, Goss KA, Petcherski A, Chandrachud U, Sheridan SD, Lucente D, Sims KB, Gusella JF, Sondhi D, Crystal RG, Reinhardt P, Sterneckert J, Schöler H, Haggarty SJ, Storch A, Hermann A, Cotman SL. Human iPSC models of neuronal ceroid lipofuscinosis capture distinct effects of TPP1 and CLN3 mutations on the endocytic pathway. Hum Mol Genet 23(8):2005-22, 2014

Kim SM, Flaßkamp H, Hermann A, Araúzo-Bravo MJ, Lee SC, Lee SH, Seo EH, Lee SH, Storch A, Lee HT, Schöler HR, Tapia N, Han DW. Direct conversion of mouse fibroblasts into induced neural stem cells. Nat Protoc 9(4):871-81, 2014

Hemkemeyer SA, Schwarzer C, Boiani M, Ehmcke J, Le Gac S, Schlatt S, Nordhoff V. Effects of embryo culture media do not persist after implantation: a histological study in mice. Hum Reprod 29(2):220-33, 2014

Tiemann U, Marthaler AG, Adachi K, Wu G, Fischedick GU, Araúzo-Bravo MJ, Schöler HR, Tapia N. Counteracting Activities of OCT4 and KLF4 during Reprogramming to Pluripotency. Stem Cell Reports 2(3):351-65, 2014

Hassani SN, Totonchi M, Gourabi H, Schöler HR, Baharvand H. Signaling Roadmap Modulating Naïve and Primed Pluripotency. Stem Cells Dev 23(3):193-208, 2014

Singhal N, Esch D, Stehling M, Schöler HR. BRG1 Is Required to Maintain Pluripotency of Murine Embryonic Stem Cells. Biores Open Access 3(1):1-8, 2014

Lojewski X, Hermann A, Wegner F, Araúzo-Bravo MJ, Hallmeyer-Elgner S, Kirsch M, Schwarz J, Schöler HR, Storch A. Human Adult White Matter Progenitor Cells Are Multipotent Neuroprogenitors Similar to Adult Hippocampal Progenitors. Stem Cells Transl Med 3(4):458-69, 2014

Ohnishi Y, Huber W, Tsumura A, Kang M, Xenopoulos P, Kurimoto K, Oles AK, Araúzo-Bravo MJ, Saitou M, Hadjantonakis AK, Hiiragi T. Cell to cell expression variability followed by signal reinforcement progressively segregates early mouse lineages. Nat Cell Biol 16(1):27-37, 2014 


Offen N, Flemming J, Kamawal H, Ahmad R, Wolber W, Geis C, Zaehres H, Schöler HR, Ehrenreich H, Müller AM, Sirén AL. Effects of erythropoietin in murine-induced pluripotent cell-derived panneural progenitor cells. Mol Med 19:399-408, 2013

Marthaler AG, Tiemann U, Araúzo-Bravo MJ, Wu G, Zaehres H, Hyun JK, Han DW, Schöler HR, Tapia N. Reprogramming to Pluripotency through a Somatic Stem Cell Intermediate. PLoS One 8(12):e85138, 2013

Grindberg RV, Yee-Greenbaum JL, McConnell MJ, Novotny M, O’Shaughnessy AL, Lambert GM, Araúzo-Bravo MJ, Lee J, Fishman M, Robbins GE, Lin X, Venepally P, Badger JH, Galbraith DW, Gage FH, Lasken RS. RNA-sequencing from single nuclei. Proc Natl Acad Sci U S A 110(49):19802-7, 2013

Böser A, Drexler HC, Reuter H, Schmitz H, Wu G, Schöler HR, Gentile L, Bartscherer K. SILAC Proteomics of Planarians Identifies Ncoa5 as a Conserved Component of Pluripotent Stem Cells. Cell Rep 5(4):1142-55, 2013

Kossack N, Terwort N, Wistuba J, Ehmcke J, Schlatt S, Schöler HR, Kliesch S, Gromoll J. A combined approach facilitates the reliable detection of human spermatogonia in vitro. Hum Reprod. 28(11):3012-25, 2013

Pfeiffer MJ, Esteves TC, Balbach T, Araúzo-Bravo MJ, Stehling M, Jauch A, Houghton FD, Schwarzer C, Boiani M. Reprogramming of two somatic nuclei in the same ooplasm leads to pluripotent embryonic stem cells. Stem Cells 31(11):2343-53, 2013

Esteves TC, van Rossem F, Nordhoff V, Schlatt S, Boiani M, Le Gac S. A microfluidic system supports single mouse embryo culture leading to full-term development. RSC Adv 3(48):26451-58, 2013

Luu PL, Schöler HR, Araúzo-Bravo MJ. Disclosing the crosstalk among DNA methylation, transcription factors, and histone marks in human pluripotent cells through discovery of DNA methylation motifs. Genome Res 23:2013-29, 2013

Lang T, Dechant M, Sanchez V, Wistuba J, Boiani M, Pilatz A, Stammler A, Middendorff R, Schuler G, Bhushan S, Tchatalbachev S, Wübbeling F, Burger M, Chakraborty T, Mallidis C, Meinhardt A. Structural and Functional Integrity of Spermatozoa Is Compromised as a Consequence of Acute Uropathogenic E. coli-Associated Epididymitis. Biol Reprod 89(3):59, 2013

Wu G, Han D, Gong Y, Sebastiano V, Gentile L, Singhal N, Adachi K, Fischedick G, Ortmeier C, Sinn M, Radstaak M, Tomilin A, Schöler HR. Establishment of totipotency does not depend on Oct4A. Nat Cell Biol 15(9):1089-97, 2013

Eggenschwiler R, Loya K, Wu G, Sharma AD, Sgodda M, Zychlinski D, Herr C, Steinemann D, Teckman J, Bals R, Ott M, Schambach A, Schöler HR, Cantz T. Sustained Knockdown of a Disease-Causing Gene in Patient-Specific Induced Pluripotent Stem Cells Using Lentiviral Vector-Based Gene Therapy. Stem Cells Transl Med 2(9):641-54, 2013

Weidgang CE, Russell R, Tata PR, Kühl SJ, Illing A, Müller M, Lin Q, Brunner C, Boeckers TM, Bauer K, Kartikasari AE, Guo Y, Radenz M, Bernemann C, Weiß M, Seufferlein T, Zenke M, Iacovino M, Kyba M, Schöler HR, Kühl M, Liebau S, Kleger A. TBX3 Directs Cell-Fate Decision toward Mesendoderm. Stem Cell Reports 1(3):248-65, 2013

Schemmer J, Araúzo-Bravo MJ, Haas N, Schäfer S, Weber SN, Becker A, Eckert D, Zimmer A, Nettersheim D, Schorle H. Transcription factor TFAP2C regulates major programs required for murine fetal germ cell maintenance and haploinsufficiency predisposes teratomas in male mice. PLoS One 8(8):e71113

Pan F, Zhang M, Wu G, Lai Y, Greber B, Schöler HR, Chi L. Topographic effect on human induced pluripotent stem cells differentiation towards neuronal lineage. Biomaterials 34:8131-9, 2013

Han DW, Tapia N, Araúzo-Bravo MJ, Lim KT, Kim KP, Ko K, Lee HT, Schöler HR. Sox2 Level Is a Determinant of Cellular Reprogramming Potential. PLoS One 8(6):e67594, 2013

Dakas PY, Parga JA, Höing S, Schöler HR, Sterneckert J, Kumar K, Waldmann H. Discovery of neuritogenic compound classes inspired by natural products. Angew Chem Int Ed Engl. 52:1-7, 2013

Kim MJ, Choi HW, Jang HJ, Chung HM, Arauzo-Bravo MJ, Schöler HR, Do JT. Conversion of genomic imprinting by reprogramming and redifferentiation. J Cell Sci 126:2516-24, 2013

Cano-Izquierdo JM, Pinzolas M, Gómez-Sanchez E, Araúzo-Bravo MJ, Ibarrola J, How well Fuzzy ARTMAP approximates functions? Journal of Intelligent & Fuzzy Systems 25(2):335-50, 2013

Bueno C, Montes R, Navarro-Montero O, Ayllón V, Ramos-Mejia V, Real PJ, Romero-Moya D, Araúzo-Bravo MJ, Menendez P. FLT3 activation cooperates with MLL-AF4 fusion protein to abrogate the hematopoietic specification of human ESCs. Blood 121(19):3867-78, 2013

Antonchick AP, López-Tosco S, Parga J, Sievers S, Schürmann M, Preut H, Höing S, Schöler HR, Sterneckert J, Rauh D, Waldmann H. Highly enantioselective catalytic synthesis of neurite growth-promoting secoyohimbanes. Chemistry & Biology 20:500-09, 2013

Pijnappel WW, Esch D, Baltissen MP, Wu G, Mischerikow N, Bergsma AJ, van der Wal E, Han DW, Bruch HV, Moritz S, Lijnzaad P, Altelaar AF, Sameith K, Zaehres H, Heck AJ, Holstege FC, Schöler HR, Timmers HT. A central role for TFIID in the pluripotent transcription circuitry. Nature 495(7442):516-9, 2013

Reinhardt P, Schmid B, Burbulla LF, Schöndorf DC, Wagner L, Glatza M, Höing S, Hargus G, Heck SA, Dhingra A, Wu G, Müller S, Brockmann K, Kluba T, Maisel M, Krüger R, Berg D, Tsytsyura Y, Thiel CS, Psathaki OE, Klingauf J, Kuhlmann T, Klewin M, Müller H, Gasser T, Schöler HR, Sterneckert J. Genetic Correction of a LRRK2 Mutation in Human iPSCs Links Parkinsonian Neurodegeneration to ERK-Dependent Changes in Gene Expression. Cell Stem Cell 12(3):354-67, 2013

Didié M, Christalla P, Rubart M, Muppala V, Döker S, Unsöld B, El-Armouche A, Rau T, Eschenhagen T, Schwoerer AP, Ehmke H, Schumacher U, Fuchs S, Lange C, Becker A, Tao W, Scherschel JA, Soonpaa MH, Yang T, Lin Q, Zenke M, Han DW, Schöler HR, Rudolph C, Steinemann D, Schlegelberger B, Kattman S, Witty A, Keller G, Field LJ, Zimmermann WH. Parthenogenetic stem cells for tissue-engineered heart repair. J Clin Invest 123(3):1285-98, 2013

Reinhardt P, Glatza M, Hemmer K, Tsytsyura, Thiel CS, Höing S, Moritz S, Parga JA, Wagner L, Bruder JM, Wu G, Schmid B, Röpke A, Klingauf J, Schwamborn JC, Gasser T, Schöler HR, Sterneckert J. Derivation and expansion using only small molecules of human neural progenitors for neurodegenerative disease modeling. PLoS One 8(3):e59252, 2013

Zhang M, Schöler HR, Greber B. Rapid and efficient generation of neurons from human pluripotent stem cells in a multititre plate format. J Vis Exp 73:e4335, 2013

Esch D, Vahokoski J, Groves MR, Pogenberg V, Cojocaru V, Vom Bruch H, Han D, Drexler HC, Araúzo-Bravo MJ, Ng CK, Jauch R, Wilmanns M, Schöler HR. A unique Oct4 interface is crucial for reprogramming to pluripotency. Nat Cell Biol  15(3):295-301, 2013

Ruiz S, Gore A, Li Z, Panopoulos AD, Montserrat N, Fung HL, Giorgetti A, Bilic J, Batchelder EM, Zaehres H, Schöler HR, Zhang K, Izpisua Belmonte JC. Analysis of protein-coding mutations in hiPSCs and their possible role during somatic cell reprogramming. Nat Commun 4:1382, 2013

Hoss M, Sarić T, Denecke B, Peinkofer G, Bovi M, Groll J, Ko K, Salber J, Halbach M, Schöler HR, Zenke M, Neuss S. Expansion and differentiation of germline-derived pluripotent stem cells on biomaterials. Tissue Eng Part A 19(9-10):1067-80, 2013

Knobloch M, Braun SMG, Zurkirchen L, Schoultz CV, Zamboni N, Araúzo-Bravo MJ, Kovacs WJ, Karalay O, Suter U, Machado RAC, Roccio M, Lutolf MP, Semenkovich CF, Jessberger S. Metabolic control of adult neural stem/progenitor cell activity by FASN-dependent lipogenesis. Nature 493(7431):226-30, 2013

Nieto-Estévez V, Pignatelli J, Araúzo-Bravo MJ, Hurtado-Chong A, Carlos Vicario-Abejón, A global transcriptome analysis reveals molecular hallmarks of neural stem cell death, survival, and differentiation in response to partial FGF-2 and EGF deprivation. PLoS One 8(1):e53594, 2013


Okamura D, Mochizuki K, Taniguchi H, Tokitake Y, Ikeda M, Yamada Y, Tournier C, Yamaguchi S, Tada T, Schöler HR, Matsui Y. REST and its downstream molecule Mek5 regulate survival of primordial germ cells. Dev Biol 372(2):190-202, 2012

Tapia N, Reinhardt P, Duemmler A, Wu G, Araúzo-Bravo MJ, Esch D, Greber B, Cojocaru V, Rascon CA, Tazaki A, Kump K, Voss R, Tanaka EM, Schöler HR. Reprogramming to pluripotency is an ancient trait of vertebrate Oct4 and Pou2 proteins. Nat Commun 3:1279, 2012

Müller-Molina AJ, Schöler HR, Araúzo-Bravo MJ. Comprehensive human transcription factor binding site map for combinatory binding motifs discovery. PLoS One 7(11):e49086, 2012

Höing S, Rudhard Y, Reinhardt P, Glatza M, Stehling M, Wu G, Peiker C, Böcker A, Parga JA, Bunk E, Schwamborn JC, Slack M, Sterneckert J, Schöler HR. Discovery of Inhibitors of Microglial Neurotoxicity Acting Through Multiple Mechanisms Using a Stem-Cell-Based Phenotypic Assay. Cell Stem Cell 11(5):620-32, 2012

Hesse M, Raulf A, Pilz GA, Haberlandt C, Klein AM, Jabs R, Zaehres H, Fügemann CJ, Zimmermann K, Trebicka J, Welz A, Pfeifer A, Röll W, Kotlikoff MI, Steinhäuser C, Götz M, Schöler HR, Fleischmann BK. Direct visualization of cell division using high-resolution imaging of M-phase of the cell cycle. Nat Commun 3:1076, 2012

Ruiz S, Diep D, Gore A, Panopoulos AD, Montserrat N, Plongthongkum N, Kumar S, Fung HL, Giorgetti A, Bilic J, Batchelder EM, Zaehres H, Kan NG, Schöler HR, Mercola M, Zhang K, Izpisua Belmonte JC. Identification of a specific reprogramming-associated epigenetic signature in human induced pluripotent stem cells. Proc Natl Acad Sci U S A 109(40):16196-201, 2012

Sabour D, Schöler HR. Reprogramming and the mammalian germline: the Weismann barrier revisited. Curr Opin Cell Biol (6):716-23, 2012

Adachi K, Schöler HR. Directing reprogramming to pluripotency by transcription factors. Curr Opin Genet Dev 22(5):416-22, 2012

Schwarzer C, Esteves TC, Araúzo-Bravo MJ, Le Gac S, Nordhoff V, Schlatt S, Boiani M. ART culture conditions change the probability of mouse embryo gestation through defined cellular and molecular responses. Hum Reprod 27(9):2627-40, 2012

Frank S, Zhang M, Schöler HR, Greber B. Small molecule-assisted, line-independent maintenance of human pluripotent stem cells in defined conditions. PLoS One 7(7):e41958, 2012

Tapia N, Han DW, Schöler HR. Restoring stem cell function in aged tissues by direct reprogramming? Cell Stem Cell 10(6):653-6, 2012

Esteves TC, Psathaki OE, Pfeiffer MJ, Balbach ST, Zeuschner D, Shitara H, Yonekawa H, Siatkowski M, Fuellen G, Boiani M. Mitochondrial physiology and gene expression analyses reveal metabolic and translational dysregulation in oocyte-induced somatic nuclear reprogramming. PLoS One 7(6):e36850, 2012

Fischedick G, Klein DC, Wu G, Esch D, Höing S, Han DW, Reinhardt P, Hergarten K, Tapia N, Schöler HR, Sterneckert JL. Zfp296 is a novel, pluripotent-specific reprogramming factor. PLoS One 7(4):e34645, 2012

Han DW, Tapia N, Hermann A, Hemmer K, Höing S, Araúzo-Bravo MJ, Zaehres H, Wu G, Frank S, Moritz S, Greber B, Yang JH, Lee HT, Schwamborn JC, Storch A, Schöler HR. Direct reprogramming of fibroblasts into neural stem cells by defined factors. Cell Stem Cell 10(4):465-72, 2012

Balbach ST, Esteves TE, Houghton FD, Siatkowski M, Pfeiffer MJ, Tsurumi C, Kanzler B, Fuellen G, Boiani M. Nuclear Reprogramming: Kinetics of Cell Cycle and Metabolic Progression as Determinants of Success. PLoS One  7(4):e35322, 2012

Moritz S, Stöckle F, Ortmeier C, Schmitz H, Rodríguez-Esteban R, Key G, Gentile L. Heterogeneity of planarian stem cells in the S/G2/M phase. Int J Dev Biol 56(1-3):117-25, 2012

Van de Kamp J, Kramann R, Anraths J, Schöler HR, Ko K, Knüchel R, Zenke M, Neuss S, Schneider RK. Epithelial morphogenesis of germline-derived pluripotent stem cells on organotypic skin equivalents in vitro. Differentiation 83(3):138-47, 2012

Pfaff N, Lachmann N, Kohlscheen S, Sgodda M, Araúzo-Bravo MJ, Greber B, Kues W, Glage S, Baum C, Niemann H, Schambach A, Cantz T, Moritz T. Efficient hematopoietic redifferentiation of induced pluripotent stem cells derived from primitive murine bone marrow cells. Stem Cells Dev 21(5):689-701, 2012

Yu KR, Yang SR, Jung JW, Kim H, Ko K, Han DW, Park SB. CD49f Enhances Multipotency and Maintains Stemness Through the Direct Regulation of OCT4 and SOX2. Stem Cells 30(5):876-87, 2012

Kleger A, Mahaddalkar P, Katz SF, Lechel A, Ju JY, Loya K, Lin Q, Hartmann D, Liebau S, Kraus J, Cantz T, Kestler HA, Zaehres H, Schöler HR, Rudolph KL. Increased Reprogramming Capacity of Mouse Liver Progenitor Cells, Compared with Differentiated Liver Cells, Requires the BAF Complex. Gastroenterology 142(4):907-17, 2012

Linta L, Stockmann M, Kleinhans KN, Böckers A, Storch A, Zaehres H, Lin Q, Barbi G, Böckers TM, Kleger A, Liebau S. Rat embryonic fibroblasts improve reprogramming of human keratinocytes into induced pluripotent stem cells. Stem Cells Dev 21(6):965-76, 2012

Sterneckert J, Höing S, Schöler HR. Concise Review: Oct4 and More: The Reprogramming Expressway. Stem Cells 30(1):15-21, 2012

Hauser S, Widera D, Qunneis F, Müller J, Zander C, Greiner J, Strauss C, Lüningschrör P, Heimann P, Schwartze H, Ebmeyer J, Sudhoff H, Araúzo-Bravo MJ, Greber B, Zaehres H, Schöler HR, Kaltschmidt C, Kaltschmidt B. Isolation of Novel Multipotent Neural Crest-Derived Stem Cells from Adult Human Inferior Turbinate. Stem Cells Dev 21(5):742-56, 2012

Löhle M, Hermann A, Glaß H, Kempe A, Schwarz SC, Kim JB, Poulet C, Ravens U, Schwarz J, Schöler HR, Storch A. Differentiation Efficiency of Induced Pluripotent Stem Cells Depends on the Number of Reprogramming Factors. Stem Cells 30(3):570-9, 2012

Ko K, Wu G, Araùzo-Bravo M, Kim J, Francine J, Greber B, Mühlisch J, Joo J, Sabour D, Frühwald, Tapia N, Schöler HR. Autologous Pluripotent Stem Cells Generated from Adult Mouse Testicular Biopsy. Stem Cell Rev 8(2):435-44, 2012


Kahr PC, Piccini I, Fabritz L, Greber B, Schöler HR, Scheld HH, Hoffmeier A, Brown NA, Kirchhof P. Systematic analysis of gene expression differences between left and right atria in different mouse strains and human atrial tissue. PLoS One 6(10):e26389, 2011

Struckmann S, Esch D, Schöler H, Fuellen G. Visualization and exploration of conserved regulatory modules using ReXSpecies 2. BMC Evol Biol 11:267, 2011

Greber B, Coulon P, Zhang M, Moritz S, Frank S, Muller-Molina AJ, Araúzo-Bravo MJ, Han DW, Pape HC, Schöler HR. FGF signaling inhibits neural induction in human embryonic stem cells. EMBO J 30(24):4874-84, 2011

Jones C, Denecke J, Sträter R, Stölting T, Schunicht Y, Zeuschner D, Klumperman J, Lefeber DJ, Spelten O, Zarbock A, Kelm S, Strenge K, Haslam SM, Lühn K, Stahl D, Gentile L, Schreiter T, Hilgard P, Beck-Sickinger AG, Marquardt T, Wild MK. A novel type of macrothrombocytopenia associated with a defect in α2,3-sialylation. Am J Pathol 179:1969-77, 2011

Jeter CR, Liu B, Liu X, Chen X, Liu C, Calhoun-Davis T, Repass J, Zaehres H, Shen JJ, Tang DG. NANOG promotes cancer stem cell characteristics and prostate cancer resistance to androgen deprivation. Oncogene 30(36):3833-45, 2011

Berneman C, Greber B, Ko K, Sterneckert J, Han DW, Araúzo-Bravo M, Schöler HR. Distinct Developmental Ground States of Epiblast Stem Cell Lines Determine Different Pluripotency Features. Stem Cells 29:1496-1503, 2011

Wu G, Liu N, Rittelmeyer I, Sharma AD, Sgodda M, Zaehres H, Bleidißel M, Greber B, Gentile L, Han DW, Rudolph C, Steinemann D, Schambach A, Ott M, Schöler HR, Cantz T. Generation of Healthy Mice from Gene-Corrected Disease-Specific Induced Pluripotent Stem Cells. PLoS Biol 9(7):e1001099, 2011

Moon JH, Heo JS, Kim JS, Jun EK, Lee JH, Kim A, Kim J, Whang KY, Kang YK, Yeo S, Lim HJ, Han DW, Kim DW, Oh S, Yoon BS, Schöler HR, You S. Reprogramming fibroblasts into induced pluripotent stem cells with Bmi1. Cell Res 21:1305-15, 2011

Choi HW, Kim JS, Choi S, Jang HJ, Kim MJ, Choi Y, Schöler HR, Chung HM, Do JT. Neural Stem Cells Achieve and Maintain Pluripotency without Feeder Cells. PLoS One 6(6):e21367, 2011

Ohlig S, Farshi P, Pickhinke U, van den Boom J, Höing S, Jakuschev S, Hoffmann D, Dreier R, Schöler HR, Dierker T, Bordych C, Grobe K. Sonic hedgehog shedding results in functional activation of the solubilized protein. Dev Cell 20(6):764-74, 2011

Ko K, Reinhardt P, Tapia N, Schneider-Kramann R, Araúzo-Bravo MJ, Han DW, Greber B, Kim J, Kliesch S, Zenke M, Schöler HR. Evaluating the Potential of Putative Pluripotent Cells Derived from Human Testis. Stem Cells 29:1304-9, 2011

Tapia N, Araúzo-Bravo MJ, Ko K, Schöler HR. Challenging the Pluripotency of Human Testis-Derived ESC-Like Cells. Stem Cells 29(8):1165-9, 2011

Pennekamp P, Feldner S, Seesing FJ, Psathaki OE, Schöler HR, Wieacker P, Dworniczak B. Bcar3 Is Expressed in Sertoli Cells and Germ Cells of the Developing Testis in Mice. Sex Dev 5(4):197-204, 2011

Terwel D, Löschmann YN, Schmidt HH, Schöler HR, Cantz T, Heneka MT. Neuroinflammatory and behavioural changes in the Atp7B mutant mouse model of Wilson's disease. J Neurochem 118(1):105-12, 2011

Minnerup J, Kim JB, Schmidt A, Diederich K, Bauer H, Schilling M, Strecker JK, Ringelstein EB, Sommer C, Schöler HR, Schäbitz WR. Effects of neural progenitor cells on sensorimotor recovery and endogenous repair mechanisms after photothrombotic stroke. Stroke 42(6):1757-63, 2011

Wu G, Schöler HR. Role of mouse maternal Cdx2: what’s the debate all about? Reproductive BioMedicine Online 22:516-18, 2011

Sharma AD, Narain N, Händel EM, Iken M, Singhal N, Cathomen T, Manns MP, Schöler HR, Ott M, Cantz T. MicroRNA-221 Regulates FAS-Induced Fulminant Liver Failure. Hepatology 53(5):1651-61, 2011

Tiemann U, Sgodda, Warlich E, Ballmeier M, Schöler HR, Schambach A, Cantz T. Optimal Reprogramming Factor Stoichiometry Increases Colony Numbers and Affects Molecular Characteristics of Murine Induced Pluripotent Stem Cells. Cytometry Part A 79A:426-35, 2011

Warlich E, Kuehle J, Cantz T, Brugman MH, Maetzig T, Galla M, Filipczyk AA, Halle S, Klump H, Schöler HR, Baum C, Schroeder T, Schambach A. Lentiviral Vector Design and Imaging Approaches to Visualize the Early Stages of Cellular Reprogramming. Mol Ther 19(4):782-9, 2011

Psathaki OE, Hübner K, Sabour D, Sebastiano V, Wu G, Sugawa F, Wieacker P, Pennekamp P, Schöler HR. Ultrastructural characterization of mouse embryonic stem cell-derived oocytes and granulosa cells. Stem Cells Dev 20(12):2205-15, 2011

Han DW, Greber B, Wu G, Tapia N, Araúzo-Bravo MJ, Ko K, Bernemann C, Stehling M, Schöler HR. Direct reprogramming of fibroblasts into epiblast stem cells. Nat Cell Biol 13(1):66-71, 2011

Nowak-Imialek M, Kues WA, Petersen B, Lucas-Hahn A, Herrmann D, Meena Haridoss S, Oropeza M, Lemme E, Schöler HR, Carnwath JW, Niemann H. Oct4-EGFP transgenic pigs - a new large animal model for reprogramming studies. Stem Cells Dev 20(9):1563-75, 2011

Wossidlo M, Nakamura T, Lepikhov K, Marques CJ, Zakhartchenko V, Boiani M, Arand J, Nakano T, Reik W, Walter J. 5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming. Nature Communication 2:241-47, 2011

Do JT, Choi HW, Choi Y, Schöler HR. Pluripotent hybrid cells contribute to extraembryonic as well as embryonic tissues. Stem Cells Dev 20(6):1063-9, 2011

Esteves TC, Balbach ST, Pfeiffer MJ, Araúzo-Bravo MJ, Klein DC, Sinn M, Boiani M. Somatic cell nuclear reprogramming of mouse oocytes endures beyond reproductive decline. Aging Cell 10(1):80-95, 2011

Pfeiffer MJ, Siatkowski M, Paudel Y, Balbach ST, Baeumer N, Crosetto N, Drexler HC, Fuellen G, Boiani M. Proteomic Analysis of Mouse Oocytes Reveals 28 Candidate Factors of the „Reprogrammome". J Proteome Research 10:2140-53, 2011

Santourlidis S, Wernet P, Ghanjati F, Graffmann N, Springer J, Kriegs C, Zhao X, Brands J, Araúzo-Bravo MJ, Neves R, Koegler G, Uhrberg M. Unrestricted somatic stem cells (USSC) from human umbilical cord blood display uncommitted epigenetic signatures of the major stem cell pluripotency genes. Stem Cell Res 6(1):60-9, 2011

Gentile L, Cebrià F, Bartscherer K. The planarian flatworm: an in vivo model for stem cell biology and nervous system regeneration. Dis Model Mech 4:12-9, 2011

Sabour D, Araúzo-Bravo MJ, Hübner K, Ko K, Greber B, Gentile L, Stehling M, Schöler HR. Identification of genes specific to mouse primordial germ cells through dynamic global gene expression. Hum Mol Genet 20(1):115-25, 2011

Wu G, Gentile L, Do JT, Cantz T, Sutter J, Psathaki K, Araúzo-Bravo MJ, Ortmeier C, Schöler HR. Efficient derivation of pluripotent stem cells from siRNA-mediated Cdx2-deficient mouse embryos. Stem Cells Dev 20(3):485-93, 2011


Som A, Harder C, Greber B, Siatkowski M, Paudel Y, Warsow G, Cap C, Schöler H, Fuellen G. The PluriNetWork: an electronic representation of the network underlying pluripotency in mouse, and its applications. PLoS One 5(12):e15165, 2010

Pfeiffer MJ, Balbach ST, Esteves TC, Crosetto N, Boiani M. Enhancing somatic nuclear reprogramming by Oct4 gain-of-function in cloned mouse embryos. Int J Dev Biol 54:1649-57, 2010

Warsow G, Greber B, Falk SS, Harder C, Siatkowski M, Schordan S, Som A, Endlich N, Scholer H, Repsilber D, Endlich K, Fuellen G. ExprEssence - Revealing the essence of differential experimental data in the context of an interaction/regulation network. BMC Syst Biol 4(1):164-82, 2010

Wu G, Gentile L, Fuchikami T, Sutter J, Psathaki K, Esteves TC, Araúzo-Bravo MJ, Ortmeier C, Verberk G, Abe K, Schöler HR. Initiation of trophectoderm lineage specification in mouse embryos is independent of Cdx2. Development 137(24):4159-69, 2010

Han DW, Tapia N, Joo JY, Greber B, Araúzo-Bravo MJ, Bernemann C, Ko K, Wu G, Stehling M, Do JT, Schöler HR. Epiblast stem cell subpopulations represent mouse embryos of distinct pregastrulation stages. Cell 143(4):617-27, 2010

Sabour D, Araúzo-Bravo MJ, Hübner K, Ko K, Greber B, Gentile L, Stehling M, Schöler HR. Identification of genes specific to mouse primordial germ cells through dynamic global gene expression. Hum Mol Genet 20(1):115-25, 2010

Sebastiano V, Dalvai M, Gentile L, Schubart K, Sutter J, Wu GM, Tapia N, Esch D, Ju JY, Hübner K, Araúzo-Bravo MJ, Schöler HR, Cavaleri F, Matthias P. Oct1 regulates trophoblast development during early mouse embryogenesis. Development 137(21):3551-60, 2010

Boiani M. Is the perfect mouse cloning experiment in sight? Biol Reprod 83:887-9, 2010

Tapia N, Schöler HR. p53 connects tumorigenesis and reprogramming to pluripotency. J Exp Med 207:2045-8, 2010

Sterneckert J, Stehling M, Bernemann C, Araúzo-Bravo MJ, Greber B, Gentile L, Ortmeier C, Sinn M, Wu G, Ruau D, Zenke M, Brintrup R, Klein DC, Ko K, Schöler HR. Neural induction intermediates exhibit distinct roles of Fgf signaling. Stem Cells 28(10):1772-81, 2010

Zhou H, Li W, Zhu S, Joo JY, Do JT, Xiong W, Kim JB, Zhang K, Schoeler HR, Ding S. Conversion of mouse epiblast stem cells to an earlier pluripotency state by small molecules. J Biol Chem 285(39):29676-80, 2010

Zaehres H, Kim JB, Schöler HR. Induced pluripotent stem cells. Methods Enzymol 476:309-25, 2010

Ko K, Araúzo-Bravo MJ, Tapia N, Kim J, Lin Q, Bernemann C, Han DW, Gentile L, Reinhardt P, Greber B, Schneider RK, Kliesch S, Zenke M, Schöler HR. Human adult germline stem cells in question. Nature 465(7301):E1, discussion E3, 2010

Gerovska D, Araúzo-Bravo MJ, Whaler K, Stavrev P, Reid A. Three-dimensional interpretation of magnetic and gravity sources using the finite difference similarity transform. Geophysics 75(4):L79-L90, 2010

Zaehres H, Kögler G, Araúzo-Bravo MJ, Bleidissel M, Santourlidis S, Weinhold S, Greber B, Kim JB, Buchheiser A, Liedtke S, Eilken HM, Graffmann N, Zhao X, Meyer J, Reinhardt P, Burr B, Waclawczyk S, Ortmeier C, Uhrberg M, Schöler HR, Cantz T, Wernet P. Induction of pluripotency in human cord blood unrestricted somatic stem cells. Exp Hematol 38(9):809-18, 2010

Singhal N, Graumann J, Wu G, Araúzo-Bravo MJ, Han DW, Greber B, Gentile L, Mann M, Schöler HR. Chromatin-remodeling components of the BAF complex facilitate reprogramming. Cell 141:943-55, 2010

Wossidlo M, Arand J, Sebastiano V, Lepikhov K, Boiani M, Reinhardt R, Schöler H, Walter J. Dynamic link of DNA demethylation, DNA strand breaks and repair in mouse zygotes. EMBO J 29(11):1877-88, 2010

Ko K, Araúzo-Bravo MJ, Kim J, Stehling M, Schöler HR. Conversion of adult mouse unipotent germline stem cells into pluripotent stem cells. Nat Protoc 5(5):921-8, 2010

Do JT, Schöler HR. Cell fusion-induced reprogramming. Methods Mol Biol 636:179-90, 2010

Fernandéz-Taboada E, Moritz S, Zeuschner D, Stehling M, Schöler HR, Saló E, Gentile L. Smed-SmB, a member of the Lsm protein superfamily, is essential for chromatoid body organization and planarian stem cell proliferation. Development 137(7):1055-65, 2010

Greber B, Wu G, Bernemann C, Joo JY, Han DW, Ko K, Tapia N, Sabour D, Sterneckert J, Tesar P, Schöler HR. Conserved and divergent roles of FGF signaling in mouse epiblast stem cells and human embryonic stem cells. Cell Stem Cell 6:215-26, 2010

Ko K, Hübner K, Müller-Keuker J, Schöler HR. In vitro derivation of germ cells from embryonic stem cells. Frontiers in Bioscience 15:46-56, 2010

Zeuschner D, Mildner K, Zaehres H, Schöler HR Induced pluripotent stem cells at nano scale. Stem Cells Dev 19(5):615-620, 2010

Gerovska D, Araúzo-Bravo MJ, Whaler K, Stavrev P, Reid A. Three-dimensional interpretation of magnetic and gravity sources using the finite difference similarity transform. Geophysics 75(4):L79-L90


Do JT, Han DW, Gentile L, Sobek-Klocke I, Wutz A, Schöler HR. Reprogramming of Xist against the pluripotent state in fusion hybrids. J Cell Sci 122:4122-9, 2009

Li W, Zhou H, Abujarour R, Zhu S, Joo JY, Lin T, Hao E, Schöler HR, Hayek A, Ding S. Generation of human induced pluripotent stem cells in the absence of exogenous Sox2. Stem Cells 27(12):2992-3000, 2009

Do JT, Joo JY, Han DW, Araúzo-Bravo MJ, Kim MJ, Greber B, Zaehres H, Sobek-Klocke I, Chung HM, Schöler HR. Generation of parthenogenetic iPS cells from parthenogenetic neural stem cells. Stem Cells 27(12):2962-68, 2009

Haase A, Olmer R, Schwanke K, Wunderlich S, Merkert S, Hess C, Zweigerdt R, Gruh I, Meyer J, Wagner S, Maier LS, Han DW, Glage S, Miller K, Fischer P, Schöler HR, Martin U. Generation of induced pluripotent stem cells from human cord blood. Cell Stem Cell 5(4):434-41, 2009

Kim JB, Zaehres H, Araúzo-Bravo MJ, Schöler HR. Generation of induced pluripotent stem cells from neural stem cells. Nature Protoc 4(10):1464-9, 2009

Kriegeskotte C, Cantz T, Haberland J, Zibert A, Haier J, Köhler G, Schöler HR, Schmidt HH, Arlinghaus HF. Laser secondary neutral mass spectrometry for copper detection in micro-scale biopsies. J Mass Spectrom 44(10):1417-22, 2009

Kim JB, Greber B, Araúzo-Bravo MJ, Meyer J, Park KI, Zaehres H, Schöler HR. Direct reprogramming of human neural stem cells by OCT4. Nature 461(7264):649-53, 2009

Loya K, Eggenschwiler R, Ko K, Sgodda M, André F, Bleidißel M, Schöler HR, Cantz T. Hepatic differentiation of pluripotent stem cells. Biol Chem 390(10):1047-55, 2009

Ko K, Tapia N, Wu G, Kim JB, Bravo MJ, Sasse P, Glaser T, Ruau D, Han DW, Greber B, Hausdörfer K, Sebastiano V, Stehling M, Fleischmann BK, Brüstle O, Zenke M, Schöler HR. Induction of pluripotency in adult unipotent germline stem cells. Cell Stem Cell 5(1):87-96, 2009

Do JT, Schöler HR. Regulatory circuits underlying pluripotency and reprogramming. Trends Pharmacol Sci 30:296-302, 2009

Han DW, Do JT, Araúzo-Bravo MJ, Lee SH, Meissner A, Lee HT, Jaenisch R, Schöler HR. Epigenetic hierarchy governing Nestin expression. Stem Cells 27:1088-97, 2009

Zhou H, Wu S, Joo JY, Zhu S, Han DW, Lin T, Trauger S, Bien G, Yao S, Zhu Y, Siuzdak G, Schöler HR, Duan L, Ding S. Generation of induced pluripotent stem cells using recombinant proteins. Cell Stem Cell 4:381-4, 2009

Saxe JP, Tomilin A, Schöler HR, Plath K, Huang J. Post-translational regulation of Oct4 transcriptional activity. PLoS One 4(2):e4467, 2009

Kim JB, Sebastiano V, Wu G, Araúzo-Bravo M, Sasse P, Gentile L, Ko K, Ruau D, Ehrich M, van den Boom D, Meyer J, Hübner K, Bernemann C, Ortmeier C, Zenke M, Fleischmann B, Zaehres H, Schöler HR Oct4-induced pluripotency in adult neural stem cells. Cell 136:411-19, 2009


Shi Y, Desponts C, Do JT, Hahm HS, Schöler HR, Ding S. Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. Cell Stem Cell 3:568-74, 2008

Zucchi I, Astigiano S, Bertalot G, Sanzone S, Cocola C, Pelucchi P, Bertoli G, Stehling M, Barbieri O, Albertini A, Schöler HR, Neel BG, Reinbold RA, Dulbecco R. Distinct populations of tumor-initiating cells derived from a tumor generated by rat mammary cancer stem cells. Proc Natl Acad Sci U S A 105:16940-5, 2008

Do JT, Han DW, Gentile L, Sobek-Klocke I, Stehling M, Schöler HR Enhanced Reprogramming of Xist by induced upregulation of Tsix and Dnmt3a. Stem Cells 26(11):2821-31, 2008

Schöler HR. Commentary: highlight on stem cell research. Biol Chem 389:789, 2008

Cantz T, Bleidissel M, Stehling M, Schöler HR. In vitro differentiation of reprogrammed murine somatic cells into hepatic precursor cells. Biol Chem 389:889-96, 2008

Kim JB, Zaehres H, Wu G, Gentile L, Ko K, Sebastiano V, Araúzo-Bravo MJ, Ruau D, Han DW, Zenke M, Schöler HR. Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors. Nature 454:646-50, 2008 

Shi Y, Do JT, Desponts C, Hahm HS, Schöler HR, Ding S. A combined chemical and genetic approach for the generation of induced pluripotent stem cells. Cell Stem Cell 2:568-74, 2008

Sharma AD, Cantz T, Vogel A, Schambach A, Haridass D, Iken M, Bleidissel M, Manns MP, Schöler HR, Ott M. Murine embryonic stem cell-derived hepatic progenitor cells engraft in recipient livers with limited capacity of liver tissue formation. Cell Transplant 17:313-23, 2008

Struckmann S, Araúzo-Bravo MJ, Schöler HR, Reinbold RA, Fuellen G. ReXSpecies -a tool for the analysis of the evolution of gene regulation across species. BMC Evol Biol 8:111 (18 pages), 2008

Han DW, Im YB, Do JT, Gupta MK, Uhm SJ, Kim JH, Schöler HR, Lee HT. Methylation status of putative differentially methylated regions of porcine IGF2 and H19. Mol Reprod Dev 75:777-84, 2008

Han DW, Do JT, Gentile L, Stehling M, Lee HT, Schöler HR. Pluripotential reprogramming of the somatic genome in hybrid cells occurs with the first cell cycle. Stem Cells 26:445-54, 2008

Cavaleri FM, Balbach ST, Gentile L, Jauch A, Böhm-Steuer B, Han YM, Schöler HR, Boiani M. Subsets of cloned mouse embryos and their non-random relationship to development and nuclear reprogramming. Mech Dev 25:153-66, 2008

Graumann J, Nina C. Hübner K, Kim JB, Ko K, Moser M, Kumar C, Cox J, Schöler HR, Mann M. SILAC-labeling and proteome quantitation of mouse embryonic stem cells to a depth of 5111 proteins. Mol Cell Proteomics 7:672-83, 2008

Cantz T, Key G, Bleidissel M, Gentile L, Han DW, Brenne A, Schöler HR. Absence of OCT4 Expression in Somatic Tumor Cell Lines. Stem Cells 26:692-7, 2008


Zaehres H, Schöler HR. Induction of Pluripotency: From Mouse to Human. Cell 131:834-5, 2007

Lengner CJ, Camargo FD, Hochedlinger K, Welstead GG, Zaidi S, Gokhale S, Schöler HR, Tomilin A, Jaenisch R. Oct4 expression is not required for mouse somatic stem cell self-renewal. Cell Stem Cell 1:403-15, 2007

Wei F, Schöler HR, Atchison ML. Sumoylation of Oct4 enhances its stability, DNA binding, and transactivation. J Biol Chem 282:21551-60, 2007

Blaschke RJ, Hahurij ND, Kuijper S, Just S, Wisse LJ, Deissler K, Maxelon T, Anastassiadis K, Spitzer J, Hardt SE, Schöler H, Feitsma H, Rottbauer W, Blum M, Meijlink F, Rappold G, Gittenberger-de Groot AC. Targeted Mutation Reveals Essential Functions of the Homeodomain Transcription Factor Shox2 in Sinoatrial and Pacemaking Development. Circulation 115:1830-8, 2007

Daley GQ, Ahrlund Richter L, Auerbach JM, Benvenisty N, Charo RA, Chen G, Deng HK, Goldstein LS, Hudson KL, Hyun I, Junn SC, Love J, Lee EH, McLaren A, Mummery CL, Nakatsuji N, Racowsky C, Rooke H, Rossant J, Schöler HR, Solbakk JH, Taylor P, Trounson AO, Weissman IL, Wilmut I, Yu J, Zoloth L. Ethics. The ISSCR guidelines for human embryonic stem cell research. Science 315:603-4, 2007

Do JT, Han DW, Gentile L, Sobek-Klocke I, Stehling M, Lee HT, Schöler HR. Erasure of cellular memory by fusion with pluripotent cells. Stem Cells 25:1013-20, 2007


Do JT, Han DW, Schöler HR. Reprogramming somatic gene activity by fusion with pluripotent cells. Stem Cell Rev 2(4):257-64, 2006

Hübner K, Kehler J, Schöler HR. Oocytes. Methods Enzymol 418:284-307, 2006

Ko K, Schöler HR. Embryonic stem cells as a potential source of gametes. Semin Reprod Med 24:322-9, 2006.

Chen S, Do JT, Zhang Q, Yao S, Yan F, Peters EC, Schöler HR, Schultz PG, Ding S. Self-renewal of embryonic stem cells by a small molecule. Proc Natl Acad Sci USA 103:17266-71, 2006

Kehler J, Hübner K, Schöler HR. Derivation of germ cells from embryonic stem cells. Ernst Schering Res Found Workshop 60:125-42, 2006

Do JT, Schöler HR. Cell-cell fusion as a means to establish pluripotency. Ernst Schering Res Found Workshop 60:35-42, 2006

Schöler HR, Wu G. Oocytes originating from skin? Nat Cell Biol 8:313-4, 2006

Cavaleri F, Gentile L, Schöler HR, Boiani M. Recombinant human albumin supports development of somatic cell nuclear transfer embryos in mice: toward the establishment of a chemically defined cloning protocol. Cloning Stem Cells 8:24-40, 2006

Ehmcke J, Hübner K, Schöler HR, Schlatt S. Spermatogonia: origin, physiology and prospects for conservation and manipulation of the male germ line. Reprod Fertil Dev 18:7-12, 2006

Tolkunova E, Cavaleri F, Eckardt S, Reinbold R, Christenson LK, Schöler HR, Tomilin A. The caudal-related protein cdx2 promotes trophoblast differentiation of mouse embryonic stem cells. Stem Cells 24:139-44, 2006


Boiani M, Schöler HR. Regulatory networks in embryo-derived pluripotent stem cells. Nat Rev Mol Cell Biol 6:872-84, 2005

Kehler J, Hübner K, Garrett S, Schöler HR. Generating oocytes and sperm from embryonic stem cells. Semin Reprod Med 23:222-33, 2005 

Boiani M, Gentile L, Gambles VV, Cavaleri FM, Redi CA, Schöler HR. Variable 'reprogramming' of the pluripotent stem cell marker Oct4 in mouse clones: distinct developmental potentials in different culture environments. Stem Cells 23:1089-104, 2005

Do JT, Schöler HR. Comparison of neurosphere cells with cumulus cells after fusion with embryonic stem cells: reprogramming potential. Reproduction, Fertility and Development 17:143-9, 2005


Kehler J, Tolkunova E, Koschorz B, Pesce M, Gentile L, Boiani M, Lomeli H, Nagy A, McLaughlin KJ, Schöler HR, Tomilin A. Oct4 is required for primordial germ cell survival. EMBO Rep 5:1078-83, 2004 

Do, JT, Schöler HR. Nuclei of embryonic stem cells reprogram somatic cells. Stem Cells 22:941-9, 2004

Boiani M, Kehler J, Schöler HR. Activity of the germline-specific Oct4-GFP transgene in normal and clone mouse embryos. Methods Mol Biol 254:1-34, 2004

Guo Y, Einhorn L, Kelley M, Hirota K, Yodoi J, Reinbold R, Schöler HR, Ramsey H, Hromas R. Redox regulation of the embryonic stem cell transcription factor oct-4 by thioredoxin. Stem Cells 22:259-64, 2004

Pan G, Qin B, Liu N, Schöler HR, Pei D. Identification of a nuclear localization signal in OCT4 and generation of a dominant negative mutant by its ablation. J Biol Chem 279:37013-20, 2004

Catena R, Tiveron C, Ronchi A, Porta S, Ferri A, Tatangelo L, Cavallaro M, Favaro R, Ottolenghi S, Reinbold R, Schöler HR, Nicolis SK. Conserved POU-binding DNA sites in the Sox2 upstream enhancer regulate gene expression in embryonic and neural stem cells. J Biol Chem 279:41846-57, 2004

Boiani M, Gambles V, Schöler HR ATP levels in clone mouse embryos Cytogenet Genome Res 105:270-8, 2004

Reményi A, Schöler HR, Wilmanns M. Combinatorial control of gene expression. Nat Struct Mol Biol 11(9):812-5, 2004


Boiani M, Eckardt S, Leu NA, Schöler HR, McLaughlin KJ. Pluripotency deficit in clones overcome by clone-clone aggregation: epigenetic complementation? EMBO J 22:5304-12, 2003

Reményi, A, Lins, K, Reinbold, R, Schöler HR, Wilmanns M. Crystal structure of a POU/HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enhancers. Genes Dev 17:2048-59, 2003

Parfenov VN, Pochukalina GN, Davis DS, Reinbold R, Schöler HR, Murti KG. Nuclear distribution of Oct-4 transcription factor in transcriptionally active and inactive mouse oocytes and its relation to RNA polymerase II and splicing factors. J Cell Biochem 89:720-32, 2003

Ohbo K, Yoshida S, Ohmura M, Ohneda O, Ogawa T, Tsuchiya H, Kuwana T, Kehler J, Abe K, Schöler HR, Suda T. Identification and characterization of stem cells in prepubertal spermatogenesis in mice. Dev Biol 258:209-25, 2003

Hübner K, Fuhrmann G, Christenso, LK, Kehler J, Reinbold, R, De La Fuente R, Wood J, Strauss III J, Boiani M, Schöler HR. Mouse embryonic stem cells in culture give rise to oocytes. Science 300:1251-6, 2003

Lins K, Reményi A, Tomilin A, Massa S, Wilmanns M, Matthias P, Schöler HR. OBF1 enhances transcriptional potential of Oct1. EMBO J 22:2188-98, 2003

Schlatt S, Honaramooz A, Boiani M, Schöler HR and Dobrinski I. Progeny from sperm obtained after ectopic grafting of neonatal mouse testes. Biol Reprod 68:2331-5, 2003

Cavaleri F, Schöler HR. Nanog: a new recruit to the embryonic stem cell orchestra. Cell 113:551-7, 2003


Anastassiadis K, Kim J, Daigle N, Sprengel R, Schöler HR, Stewart AF. A predictable ligand regulated expression strategy for stably integrated transgenes in mammalian cells in culture Gene 298:159-72, 2002

Honaramooz A, Snedaker A, Boiani M. Schöler HR, Dobrinski I, Schlatt S. Developmental potential of testis grafts: sperm from neonates. Nature 418:778-81, 2002

Perspectives article on Boiani et al. (2002) by Solter D. Cloning v. Clowning. Genes Dev 16:1163-6, 2002

Boiani M, Eckardt S, Schöler HR, McLaughlin KJ. Oct4 distribution and level in mouse clones: consequences for pluripotency. Genes Dev 16:1209-19, 2002

Guo Y, Costa R, Ramsey H, Starnes T, Vance G, Robertson K, Kelley M, Reinbold R, Schöler HR, Hromas R. The embryonic stem cell transcription factors Oct-4 and FoxD3/Genesis interact to regulate endodermal-specific promoter expression. Proc Natl Acad Sci U S A 99:3663-7, 2002

Pan GJ, Chang ZY, Schöler HR, Pei DQ. Stem cell pluripotency and transcription factor Oct-4. Cell Res 12(5-6):321-29, 2002

Reményi A, Tomilin A, Schöler HR, Wilmanns M. Differential Activity by DNA-induced Quarternary Structures of POU Transcription Factors. Biochemical Pharmacology 64:979-84, 2002


Reményi A, Tomilin A, Pohl E, Lins K, Philippsen A, Reinbold R, Schöler HR, Wilmanns M. Differential dimer activities of the transcription factor Oct-1 by DNA-induced interface swapping. Mol Cell 8:569-80, 2001

News and Views article on Fuhrmann et al. Dev Cell (2001) by Donovan PJ. High Oct-ane fuel powers the stem cell. Nat Genet 29:246-7, 2001

Fuhrmann G, Chung AC, Jackson KJ, Hummelke G, Baniahmad A, Sutter J, Sylvester I, Schöler HR, Cooney AJ. Mouse germline restriction of Oct4 expression by germ cell nuclear factor. Dev Cell 1:377-87, 2001

Reményi A, Pohl E, Schöler HR, Wilmanns M. Crystallization of redox-insensitive Oct1 POU domain with different DNA-response elements. Acta Crystallogr D Biol Crystallogr 57:1634-8, 2001

Ronfani L, Ferraguti M, Croci L, Ovitt CE, Schöler HR, Consalez GG, Bianchi ME. Reduced fertility and spermatogenesis defects in mice lacking chromosomal protein Hmb2. Development 128:1265-73, 2001

Nordhoff V, Hübner K, Bauer A, Orlova I, Malapetsa A, Schöler HR. Comparative analysis of human, bovine, and murine Oct-4 upstream promoter sequences. Mamm Genome 12:309-17, 2001

Pesce M, Schöler HR. Oct-4: gatekeeper in the beginnings of mammalian development. Stem Cells 19:271-8, 2001


Tomilin A, Reményi A, Lins K, Bak H, Leidel S, Vriend G, Wilmanns M, Schöler HR. Synergism with the coactivator OBF-1 (OCA-B, BOB-1) is mediated by a specific POU dimer configuration. Cell 103:853-64, 2000

Voss AK, Thomas T, Petrou P, Anastassiadis K, Schöler H, Gruss P. Taube nuss is a novel gene essential for the survival of pluripotent cells of early mouse embryos. Development 127:5449-61, 2000

Butteroni C, De Felici M, Schöler HR, Pesce M. Phage display screening reveals an association between germline-specific transcription factor Oct-4 and multiple cellular proteins. J Mol Biol 304:529-40, 2000

Kirchhof N, Carnwath JW, Lemme E, Anastassiadis K, Schöler HR, Niemann H. Expression pattern of Oct-4 in preimplantation embryos of different species. Biol Reprod 63:1698-705, 2000

Ambrosetti DC, Schöler HR, Dailey L, Basilico C. Modulation of the activity of multiple transcriptional activation domains by the DNA binding domains mediates the synergistic action of Sox2 and Oct-3 on the fibroblast growth factor-4 enhancer. J Biol Chem 275:23387-97, 2000

Anderson R, Copeland TK, Schöler HR, Heasman J, Wylie C. The onset of germ cell migration in the mouse embryo. Mech Dev 91:61-8, 2000

Pesce M, Schöler HR. Oct-4: control of totipotency and germline determination. Mol Reprod Dev 55:452-7, 2000


Yoshimizu Y, Sugiyama N, De Felice M, Yeom YI, Ohbo K, Masuko K, Obinata M, Abe K, Schöler HR, Matsui Y. Germline-specific expression of the Oct-4/green fluorescent protein (GFP) transgene in mice. Develop. Growth Differ 41:675-84, 1999

Pesce M, Marin Gomez M, Philipsen S, Schöler HR. Binding of Sp1 and Sp3 transcription factors to the Oct-4 promoter. Cell Mol Biol 45(5):709-16, 1999

Fuhrmann G, Sylvester I, Schöler HR. Repression of Oct-4 during embryonic cell differentiation correlates with the appearance of TRIF, a transiently induced DNA-binding factor. Cell Mol Biol  45(5):717-24, 1999

Angrand PO, Daigle N, van der Hoeven F, Schöler HR, Stewart AF. Simplified generation of targeting constructs using ET recombination. Nucleic Acids Res 27(17):e16, 1999

Brehm A, Ohbo K, Zwerschke W, Botquin V, Jansen-Dürr P, Schöler HR. Synergism with germ line transcription factor Oct-4: viral oncoproteins share the ability to mimic a stem cell-specific activity. Mol Cell Biol 19:2635-43, 1999

Pesce M, Anastassiadis K, Schöler HR. Oct-4: lessons of totipotency from embryonic stem cells. Cells Tissues Organs 165:144-52, 1999


Nichols J, Zevnik B, Anastassiadis K, Niwa H, Klewe-Nebenius D, Chambers I, Schöler H, Smith A. Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell 95:379-91, 1998

De Felice M, Ovitt C, Biffali E, Rodriguez-Mallon A, Arra C, Anastassiadis K, Macchia PE, Mattei MG, Mariano A, Schöler H, Macchia V, Di Lauro R. A mouse model for hereditary thyroid dysgenesis and cleft palate. Nat Genet 19:395-8, 1998

Pesce M, Wang X, Wolgemuth DJ, Schöler HR Differential expression of the Oct-4 transcription factor during mouse germ cell differentiation. Mech Dev 71:89-98, 1998

Botquin V, Hess H, Fuhrmann G, Anastassiadis C, Gross MK, Vriend G, Schöler HR. New POU dimer configuration mediates antagonistic control of an osteopontin preimplantation enhancer by Oct4 and Sox-2. Genes Dev 12:2073-90, 1998

Ovitt CE, Schöler HR. The molecular biology of Oct-4 in the early mouse embryo. Mol Hum Reprod 4:1021-31, 1998

Pesce M, Gross MK, Schöler HR. In line with our ancestors: Oct-4 and the mammalian germ. BioEssays 20:722-32, 1998

Brehm A, Ovitt CE, Schöler HR. Oct-4: more than just a POUerful marker of the mammalian germline? APMIS 106:114-26, 1998


Brehm A, Ohbo K, Schöler HR. The carboxy-terminal transactivation domain of Oct-4 acquires cell specificity through the POU domain. Mol Cell Biol 17:154-62, 1997

Bertocchini F, Ovitt CE, Contil A, Barone V, Schöler HR, Bottinelli R, Reggiani C, Sorrentino V. Requirement of the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles. EMBO J 16:6956-63, 1997


Yeom YI, Fuhrmann G, Ovitt CE, Brehm A, Ohbo K, Gross M, Hübner K, Schöler HR. Germline regulatory element of Oct-4 specific for the totipotent cycle of embryonal cells. Development 122:881-94, 1996

Minucci S, Botquin V, Yeom YI, Dey A, Sylvester I, Zand DJ, Ohbo K, Ozato K, Schöler HR. Retinoic acid-mediated down-regulation of Oct3/4 coincides with the loss of promoter occupancy in vivo. EMBO J 15:888-99, 1996


Palmieri SL, Peter W, Hess H, Schöler HR. Oct-4 transcription factor is differentially expressed in the mouse embryo during establishment of the first two extraembryonic cell lineages involved in implantation. Dev Biol 166:259-67, 1994

Sylvester I, Schöler HR. Regulation of the Oct-4 gene by nuclear receptors. Nucleic Acids Res 22:901,1994


Suzuki N, Peter W, Ciesiolka T, Gruss P, Schöler HR. Mouse Oct-1 contains a composite homeodomain of human Oct-1 and Oct-2. Nucleic Acids Res 21:245-52, 1993


Yeom YI, Ha HS, Balling R, Schöler HR, Artzt K. Structure, expression and chromosomal location of the Oct-4 gene. Mech Dev 35:171-9, 1991

Schöler HR, Ciesiolka T, Gruss P. A nexus between Oct-4 and E1A: implications for gene regulation in early embryonic stem cells. Cell 66:291-304, 1991

Schöler HR. Octamania: the POU factors in murine development. Trends Genet 7:323-30, 1991


Henseling U, Schmidt W, Schöler HR, Gruss P, Hatzopoulos AK. A transcription factor interacting with the class I gene enhancer is inactive in tumorigenic cell lines which suppress major histocompatibility complex class I genes. Mol Cell Biol 10:4100-09, 1990

Suzuki N, Rohdewohld H, Neuman T, Gruss P, Schöler HR. Oct-6: a POU transcription factor expressed in embryonal stem cells and in the developing brain. EMBO J 9:3723-32,1990

Schöler HR, Dressler GR, Balling R, Rohdewohld H, Gruss P. Oct-4: a germline-specific transcription factor mapping to the mouse t-complex. EMBO J 9:2185-95, 1990

Schöler HR, Ruppert S, Suzuki N, Chowdhury K, Gruss P. New type of POU domain in germ line-specific protein Oct-4. Cloning and characterization of the germline-specific octamer binding protein Oct-4. Nature 344:435-9, 1990

Schöler HR, Hatzopoulos AK, Balling R, Suzuki N, Gruss P. A family of octamer-specific proteins present during mouse embryogenesis: evidence for germline-specific expression of an Oct-factor. EMBO J 8:2543-50, 1989

Schöler HR, Balling R, Hatzopoulos AK, Suzuki N, Gruss P. Octamer binding proteins confer transcriptional activity in early mouse embryogenesis. EMBO J 8:2551-7, 1989

Schöler HR, Balling R, Hatzopoulos AK, Suzuki N, Gruss P. Transcriptional activity of the octamer motif in embryonic stem cells and preimplantation embryos. Hormones and Cell Regulation 198:91-8, 1989

Bohmann D, Keller W, Dale T, Schöler HR, Tebb G, Mattaj IW. A transcription factor which binds to the enhancers of SV40, immunoglobulin heavy chain and U2 snRNA genes. Nature 325:268-72, 1987

Schlokat U, Bohmann D, Schöler HR, Gruss P. Nuclear factors binding specific sequences within the immunoglobulin enhancer interact differentially with other enhancer elements. EMBO J 5:3251-8, 1986

Schöler HR, Haslinger A, Heguy A, Holtgreve H, Karin M. In vivo competition between a metallothionein regulatory element and the SV40 enhancer. Science 232:76-80, 1986

Schöler HR, Gruss P. Cell type-specific transcriptional enhancement in vitro requires the presence of transacting factors. EMBO J 4:3005-13, 1985

Schöler HR, Gruss P. Specific interaction between enhancer-containing molecules and cellular components. Cell 36:403-11, 1984


Book chapters and short communications

Book chapters:

Balbach ST, Cavaleri FM, Gentile L, Araúzo-Bravo MJ, Schöler HR, Crosetto N, Boiani M. Observing and Manipulating Pluripotency in Normal and Cloned Mouse Embryos. In: Baharvand H. ed. Trends in Stem Cell Biology and Technology. Humana Press, 2009: 101

Cavaleri F, Schöler HR. Molecular Facets of Pluripotency. In: Lanza, R, Handbook of Stem Cells; 2004: 27

Boiani M, Schöler HR. Pluripotency in Normal and Clone Mouse Embryos. In: Lanza, R, Handbook of Stem Cells; 2004: 639

Boiani M, Schöler HR. Determinants of pluripotency in mammals. In: Cibelli, j. Lanza, RP, Campbell, KHS, West M, Principles of Cloning; 2002: 109

Ovitt CE, Yeom YI, Schöler HR. Using LacZ as a reporter for transgenic analysis of embryonic gene expression. In: Cid-Arregui A, Garcia-Carranca A. Microinjection and Transgenesis. Strategies and Protocols; 1997: 427

Schöler HR, Hatzopoulos AK, Schlokat U. Enhancers and trans-acting factors. In: Kahl G, ed. Architecture of Eukaryotic Genes. Verlag Chemie, Weilheim; 1988: 89

Chowdhury K, Schöler HR, Gruss P. SV40 als modellsystem zum studium eukaryontischer genregulation. In: Blüm N, ed. Molekular- und Zellbiologie. Springer Verlag; 1985: 177.

Schöler HR, Schlokat U, Gruss P. Cell specific factors required for transcriptional enhancement in vitro. In: Gluzman Y, ed. Cold Current Topics in Molecular Biology: Eukaryotic Transcription: The Role of Cis- and Trans Acting Elements in Initiation. Spring Harbor; 1985:101

Schöler HR, Gruss P. Competition for cellular factors required for the transcriptional activation of enhancers. In: Gluzman Y, Shenk T, eds. Current Topics in Molecular Biology: Enhancers and Eukaryotic Gene Expression. Cold Spring Harbor; 1983:16

Short Communications:

Kues WA, Carnwath JW, Niemann H, Schöler HR, Paul D. A vector-based selection system for totipotent porcine cell lines. Theriogenology 49: 239, 1998 

Peter W, Hübner K, Schöler HR. Interaction of EC cell specific proteins with transcription factor Oct-4. J Cell Biochem 17A: 88, 1993

Hübner K, Kessler C, Schöler HR. Translation of eukaryotic messenger RNA in cell-free extracts. Fresenius Z Anal Chem 329: 428, 1988

Schöler HR, Gruss P. Enhancers as transcriptional control elements. Hoppe-Seyler's Z Physiol Chem 365: 214, 1984

Other publications:

Fiester A, Schöler HR, Caplan A. Stem cell therapies: time to talk to the animals. Cloning Stem Cells 6:3, 2004

Expert contribution to report "On the State of the Science of Stem Cells" as requested by Tommy G. Thompson, Secretary of Health and Human Services, USA

Schöler HR. Das Potential von Stammzellen: Ist der Mensch regenerierbar? In Kosmos, Erde, Leben (2003)

Modified as Article in: Naturwissenschaftliche Rundschau 56, 524 (2003)
Schöler HR. Das Potential von Stammzellen: Ist der Mensch regenerierbar? Bundesgesundheitsblatt

Schöler HR. Das Potential von Stammzellen: Eine Bestandsaufnahme 47: 565, 2004

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