On the cover of Cell Stem Cell (Dec. 5, 2019): Reprogramming unleashed.

In this issue, Velychko et al. (737–753) found that omitting Oct4 from the reprogramming cocktail generates mouse iPSCs with the developmental potential equivalent to that of ESCs, which are considered the gold standard. The illustration depicts Oct4 as an elephant in the room—it is not only unnecessary, but even detrimental, for the reprogramming process.
Cover artwork by Leah Saulnier.

#OpenUpStemCells – Scientists answer your questions

November 26, 2019

Erik Tolen of the MPI for Molecular Biomedicine answers the question "What are stem cells?"


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